2002
DOI: 10.1001/archderm.138.8.1101
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Androgenetic Alopecia: Analysis of Proliferation and Apoptosis

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Cited by 15 publications
(22 citation statements)
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“…1044 Progressive fibroplasia of the perifollicular sheath appears to be a common process; this may result in the miniaturization of the follicle, rather than being a consequence of it. 978, 1043 In one study, telogen hairs constituted 16% of the total, compared to 6.5% in normal subjects. 1047 There is also an increase in the number of telogen and catagen hairs relative to the number of anagen hairs.…”
Section: Treatment Of Androgenetic Alopeciamentioning
confidence: 98%
See 1 more Smart Citation
“…1044 Progressive fibroplasia of the perifollicular sheath appears to be a common process; this may result in the miniaturization of the follicle, rather than being a consequence of it. 978, 1043 In one study, telogen hairs constituted 16% of the total, compared to 6.5% in normal subjects. 1047 There is also an increase in the number of telogen and catagen hairs relative to the number of anagen hairs.…”
Section: Treatment Of Androgenetic Alopeciamentioning
confidence: 98%
“…685,963,1040 The random intermingling of miniaturized and terminal follicles has been called anisotrichosis, analogous to anisocytosis of the peripheral blood film which is characterized by red cells of variable size. 1043 Only in very advanced stages do the vellus follicles disappear, leaving thin hyaline strands in the dermis. 1042 There is a decreased proliferation of keratinocytes as evidenced by the significant decrease in Ki-67 expression.…”
Section: Treatment Of Androgenetic Alopeciamentioning
confidence: 99%
“…The mechanism by which this decrease occurs is unexplained, and may be the result of either apoptotic cell death, decreased proliferation of keratinocytes [41], cell displacement with loss of cellular adhesion leading to dermal papilla fibroblasts dropping off into the dermis, or migration of dermal papilla cells into the dermal sheath associated with the outer root sheath of the hair follicle [39].…”
Section: Reviewmentioning
confidence: 99%
“…As a consequence, apoptosis ought to be observed within the dermal papilla. However, this is not the case [6, 7], and in striking contrast the dermal papilla is rather a tissue which is protected from apoptosis by high bcl-2 expression [8]. Therefore, other mechanisms must take place, and cell displacement or migration might be an additional explanation.…”
Section: The Use Of In Vitro or Ex Vivo Techniques Inhair Researchmentioning
confidence: 99%