Androgen Transport and Receptor Mechanisms in Testis and Epididymis

French, Frank S.; McLean, W. S.; Smith, Albert A.; Tindall, Donald J.; Weddington, S. C.; Petrusz, Peter; Sar, Madhabananda; Stumpf, Walter E.; Nayfeh, Shihadeh N.

doi:10.1007/978-1-4684-2595-6_16

Cited by 9 publications

(6 citation statements)

References 25 publications

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“…Mechanistically, the observed negative effect of aspirin on sperm motility and vitality may be due to increased oxidative stress, which results from accumulation of reactive oxygen species (Alzoubi et al., 2018; Hani & Bayachou, 2014), and hence oxidative damage to spermatozoa, and decreased synthesis of gonadal hormones, particularly testosterone, which is the crucial hormone that triggers the spermatogenesis in the testis (Banihani, 2020; French et al., 1974). In addition, aspirin was found to reduce the formation of testicular prostaglandins and reduce the function of nuclear factor kappa‐light‐chain‐enhancer (Banihani, 2020; Yin et al., 1998).…”

Section: Discussionmentioning

confidence: 99%

Aspirin decreases human sperm motility and vitality, chelates seminal calcium, but insignificantly reduces seminal nitric oxide production

Banihani

Shatnawi

2020

Andrologia

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Aspirin (2-acetoxybenzoic acid), or acetylsalicylic acid, is an anti-inflammatory, analgesic and antipyretic medication (Banihani, 2019; Yin, Yamamoto, & Gaynor, 1998). It is one of the nonsteroidal anti-inflammatory drugs (NSAIDs) (Webb et al., 2019). Currently, aspirin is extensively used to increase the thinning effect of the blood or reduce the blood clots as it inhibits the function of platelets (Jia et al., 2019; Shen et al., 2019; Xu et al., 2019). Therefore, as urgent medical practice, to reduce the risk of death, aspirin is highly recommended just after the event of a heart attack (Dalen, 2006; McNeil et al., 2018). However, recurrent use of aspirin has been found to have serious adverse effects such as stomach bleeding and stomach ulcer (Chen et al., 2017; Taha, McCloskey, McSkimming, & McConnachie, 2018). Biochemically, aspirin suppresses the formation of prostaglandins and thromboxanes (Gimenez-Bastida, Boeglin, Boutaud, Malkowski, & Schneider, 2019; Rauzi et al., 2016) since it irreversibly inactivates cyclooxygenase (prostaglandin-endoperoxide synthase), which is an enzyme that catalyses the formation of prostanoids such as prostaglandins (e.g. prostacyclin) and thromboxane from

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Section: Discussionmentioning

confidence: 99%

Aspirin decreases human sperm motility and vitality, chelates seminal calcium, but insignificantly reduces seminal nitric oxide production

Banihani

Shatnawi

2020

Andrologia

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“…When testosterone is administered together with FSH in vivo an augmentation of the ABP response above that found with FSH alone is observed (17). This increased binding activity might be due to a synergism between testosterone and FSH.…”

Section: Fsh Stimulation Of Protein Kinase Inhibitormentioning

confidence: 88%

“…FSH was found to stimulate ABP in intact testes (17,18), Sertoli cell-enriched rat testes (19), isolated seminiferous tubules (20), and Sertoli cells maintained in primary culture (21,22). Although highly purified FSH elicited a response in vivo, there was no stimulation with thyroid stimulating hormone, prolactin or growth hormone.…”

Section: Fsh Stimulation Of Protein Kinase Inhibitormentioning

confidence: 95%

Factors affecting Sertoli cell function in the testis.

Tindall¹,

Tash²,

Means³

1981

Environ Health Perspect

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The Sertoli cell is the primary target for FSH action in the mammalian testis. These cells contain the majority of testicular plasma membrane receptors for this hormone. Receptor occupancy is directly correlated with a stimulation of adenylyl cyclase and a decrease in the activity of a cytoplasmic Ca++-sensitive cAMP phosphodiesterase. Regulation of these two enzymes allows increased intracellular accumulation of cAMP, activation of cAMP-dependent protein kinase and phosphorylation of a variety of protein substrates. All of these events occur within the first 30 min following exposure of isolated Sertoli cells to FSH. RNA and protein synthesis are also enhanced by FSH. Previous studies have suggested that this gonadotropin may augment the overall cellular synthesis of proteins. Our results reveal that protein kinase inhibitor (PKI) is selectively elevated by FSH both in vivo and in vitro. PKI thus becomes the initial intracellular protein whose synthesis is under FSH control. In addition to effects on protein synthesis, FSH also positively modulates the secretion of several specific proteins. One of the proteins in this latter category is androgen binding protein (ABP). Again, regulation can be observed both in vivo and in vitro. Elevated synthesis of PKI occurs prior to demonstrable secretion of ABP. Both of these events occur subsequent to the effects of FSH on cAMP metabolism. Indeed cAMP (or any of several nonhydrolyzable derivatives) can substitute for FSH in vitro. The temporal sequence of events subsequent to hormone binding and cAMP production are identical, but occur more rapidly. Together these data support the hypothesis that most of the biochemical steps leading to the synthesis and secretion of proteins by FSH are regulated by elevated levels of cAMP.

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Section: Hormonal Regulation Of Abp Another Protein In the Sertoli Cementioning

confidence: 99%

Factors Affecting Sertoli Cell Function in the Testis

Tindall¹,

Tash²,

Means³

1981

Environmental Health Perspectives

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JSTOR is a not-for-profit service that helps scholars, researchers, and students discover, use, and build upon a wide range of content in a trusted digital archive. We use information technology and tools to increase productivity and facilitate new forms of scholarship. For more information about JSTOR, please contact support@jstor.org.. The National Institute of Environmental Health Sciences (NIEHS) and Brogan & Partners are collaborating with JSTOR to digitize, preserve and extend access to Environmental Health Perspectives. The Sertoli cell is the primary target for FSH action in the mammalian testis. These cells contain the majority of testicular plasma membrane receptors for this hormone. Receptor occupancy is directly correlated with a stimulation of adenylyl cyclase and a decrease in the activity of acytoplasmic Ca + + -sensitive cAMP phosphodiesterase. Regulation of these two enzymes allows increased intracellular accumulation of cAMP, activation of cAMP-dependent protein kinase and phosphorylation of a variety of protein substrates. All of these events occur within the first 30 min following exposure of isolated Sertoli cells to FSH. RNA and protein synthesis are also enhanced by FSH. Previous studies have suggested that this gonadotropin may augment the overall cellular synthesis of proteins. Our results reveal that protein kinase inhibitor (PKI) is selectively elevated by FSH both in vivo and in vitro. PKI thus becomes the initial intracellular protein whose synthesis is under FSH control. In addition to effects on protein synthesis, FSH also positively modulates the secretion of several specific proteins. One of the proteins in this latter category is androgen binding protein (ABP). Again, regulation can be observed both in vivo and in vitro. Elevated synthesis of PKI occurs prior to demonstrable secretion of ABP. Both of these events occur subsequent to the effects of FSH on cAMP metabolism. Indeed cAMP (or any of several nonhydrolyzable derivatives) can substitutefor FSH in vitro. The temporal sequence of events subsequent to hormone binding and cAMP production are identical, but occur more rapidly. Together these data support the hypothesis that most of the biochemical steps leading to the synthesis and secretion of proteins by FSH are regulated by elevated levels of cAMP.

show abstract

Androgen Transport and Receptor Mechanisms in Testis and Epididymis

Cited by 9 publications

References 25 publications

Aspirin decreases human sperm motility and vitality, chelates seminal calcium, but insignificantly reduces seminal nitric oxide production

Aspirin decreases human sperm motility and vitality, chelates seminal calcium, but insignificantly reduces seminal nitric oxide production

Factors affecting Sertoli cell function in the testis.

Factors Affecting Sertoli Cell Function in the Testis

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