Androgen receptor‐neuroendocrine double‐negative tumor with squamous differentiation arising from treatment‐refractory metastatic castration‐resistant prostate cancer

Abstract

Abbreviations & Acronyms AMPC = amphicrine prostate cancer composed of cells coexpressing AR and NE genes AR = androgen receptor ARI = AR signaling inhibitor ARLPC = AR-low prostate cancer ARPC = AR-high prostate cancer CGA = chromogranin A CK5/6 = cytokeratin5/6 CT = computed tomography DNPC = double-negative tumors lacking the expression of AR and NE genes EP = etoposide and cisplatin H&E = hematoxylin and eosin LHRH = luteinizing hormonereleasing hormone mCRPC = metastatic castrationresistant prostate cancer NE = neuroendocrine NEK6 = mitotic-related serine/ threonine kinase NSE = neuron-specific enolase PCa = prostate cancer PDX = patient-derived xenograft PSA = prostate-specific antigen SCNPC = tumors with small cell or NE gene expression without AR activity SYP = synaptophysin