Androgen deprivation therapy and cardiovascular complications

Abstract

Cardiovascular complications associated with the use of antiandrogens have already been known for some time. Based on the results of the latest meta-analyses and clinical studies published in the last few years, the attention of the scientifi c community is focused on the deleterious cardiovascular effects of gonadotropine-releasing hormon agonists in context of the androgen deprivating therapy. The cardiac toxicity is a problem especially in patients with preexisting cardiovascular comorbidities. Increased arterial wall thickening along with endothelial dysfunction has been observed in patients with descreased androgens levels in the peripheral blood. The treatment with gonadotropine-releasing hormon agonists may disrupt the intracellular concentration of calcium ions and the contractile process and potentially result in pathological remodelling of heart. Here, we give several possible mechanisms of action of gonadotropine-releasing hormon agonists on the cardiovascular system that may be a potential explanation of the clinical observations (Ref. 44). Text in PDF www.elis.sk.

Screening and Analysis of Aortic Dissection Based on Bioinformatics Methods Related Key Genes and Early Prevention and Treatment

“…In other respects, we see that seramine protein (FLN) is actin cross-linked protein, as a scaffold protein, FLN is closely related to cytoskeletal stability [38] , studies have shown that FOS can regulate Filamin A (FLNA) high expression in aortic Smooth Muscle Cells (SMCs) in healthy people, while both FOS and FLNA are significantly downregulated in aortic smooth muscle cell SMCs in AD samples, which may be related to the pathological mechanism of AD occurrence [39] . GnRH secretion, as gonadotropinreleasing hormone, may disrupt the intracellular concentration and contractile process of calcium ions with agonist therapy and may lead to pathological remodeling of the heart [40] . On the other hand, cardiac involvement is one of the most common complications of Legionella pneumonia, which can manifest as myocarditis, pericarditis, and prosthetic valve endocarditis, and even further and permanent myocardial damage [41] .…”

The effect of GnRH agonists on angiogenesis and its implications for the myocardium in patients with cardiac risk

“…GnRH agonists are the most common type of the androgen deprivation therapy (ADT) for the treatment of patients with prostate cancer. Despite that, the relationship between GnRH agonists and cardiovascular (CV) disease remains controversial (1,2,3). Multiple studies have reported that low testosterone levels correlate with poor CV health and increased risk of CV events (4).…”