A cross-sectional study on gut microbiota in prostate cancer patients with prostatectomy or androgen deprivation therapy

Li, Kai Man; Wang, Lin; Wong, Christine Yim‐Ping; Chiu, Peter Ka Fung; Teoh, Jeremy Yuen‐Chun; Kwok, Hilda S. W.; Leung, S. F.; Wong, Sunny H.; Tsui, Stephen Kwok‐Wing; Ng, Chi‐Fai

doi:10.1038/s41391-021-00360-1

Cited by 18 publications

(10 citation statements)

References 52 publications

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“…Second, most patients are under different regimens for disease control, which may influence microbiota composition. A study by Li et al presented different gut microbiome compositions in patients with PC who underwent androgen deprivation therapy and prostatectomy [ 26 ]. Furthermore, urine samples were collected from mid-term voided urine, and different collection methods, including catheterized urine collection, may identify different microbes residing in the bladder and urethra.…”

Section: Discussionmentioning

confidence: 99%

Exploring the Association between Gut and Urine Microbiota and Prostatic Disease including Benign Prostatic Hyperplasia and Prostate Cancer Using 16S rRNA Sequencing

Tsai

Wang

et al. 2022

Biomedicines

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Numerous microorganisms residing in the gastrointestinal and genitourinary tracts affect host health. We investigated stool and voided urine samples collected from patients with benign prostatic hyperplasia (BPH) or prostate cancer (PC) and a control group to explore the potential relationship between human microbiota and prostatic disease, and aimed to identify correlations and pathogenic taxonomic units. We studied microbial composition using 16S rRNA sequencing to identify operational taxonomic units (OTUs). Extracted genome was amplified and filtered sequences were used to classify OTUs based on their specific taxonomy. No statistically significant differences were observed in stool samples among the groups. However, urine samples indicated different microbiota compositions in different patient populations. The top five microbial genera that showed significant differences between the BPH and control groups were Alcaligenes, Pseudomonas, Lactobacillus, Akkermansia, and Cetobacterium. Faecalibacterium, Staphylococcus, Ruminococcaceae_UCG_002, Neisseria, and Agathobacter were the genera with the largest proportion differences when comparing the PC and control groups. We discovered that the urine microbiota composition of the BPH and PC groups was distinct from that of the control group. Due to the impact of microbiota on prostatic disease, it is necessary to identify specific microbes for further research.

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Section: Discussionmentioning

confidence: 99%

Exploring the Association between Gut and Urine Microbiota and Prostatic Disease including Benign Prostatic Hyperplasia and Prostate Cancer Using 16S rRNA Sequencing

Tsai

Wang

et al. 2022

Biomedicines

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“… Limited sample, narrow screening range Fecal (gastrointestinal) material Matsushita et al (2021) 69 96 PCa and 56 benign, randomized to 114 development and 38 validation cohorts 16S rRNA gene amplicon sequencing Short-chain fatty acid generating bacteria ( Rikenellaceae , Alistipes , Lachnospira ) increased in high risk PC (GS ≥ 7), with a predictive index generated with 18 bacteria having AUC of 0.85 Limited ethnicity (Japanese), function of microbiota unknown. Li et al (2021) 72 56 PC on ADT, 30 PC on RP 16S rRNA gene amplicon sequencing Low alpha diversity in the ADT cohort, with higher Ruminococcus gnavus and Bacteroides spp. Lachnospira and Roseburia were higher in the RP group.…”

Section: Microbiomes Of Urologic Diseasementioning

confidence: 99%

“… 69 Identified bacteria include, but are not limited to, Staphylococcus , Streptococcus , and Bacteroides. 70 , 71 Use of androgen deprivation therapy (ADT) significantly altered microbial diversity, with higher Ruminococcus gnavus and Bacteroides 72 and decrease in Corynebacterium. 73 Matched analyses between hormone-sensitive PC and castration-resistant PC after ADT have shown similar increases of Bacteroides , Fusobacteria , Synergistetes , and Tenericutes , with corresponding decreases of Proteobacteria , Actinobacteria , and Cyanobacteria.…”

Section: Microbiomes Of Urologic Diseasementioning

confidence: 99%

Possibilities and limitations of using low biomass samples for urologic disease and microbiome research

Kim

Song

Jung

et al. 2022

Prostate International

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“…In another study aiming to investigate whether the fecal microbiota in PCa patients who had undergone prostatectomy or ADT differs, the fecal microbiota of 86 PCa-recruited patients (56 patients on ADT and 30 patients with prostatectomy) were analyzed by the 16S rRNA gene for α- and ß-diversities [ 139 ]. The authors observed a significantly lower alpha-diversity and Firmicutes-to-Bacteroidetes ratio in the ADT group.…”

Section: Developing Therapeutic Applications Targeting the Microbiomementioning

confidence: 99%

Microbiome and Prostate Cancer: A Novel Target for Prevention and Treatment

Kuštrimović

Bombelli

Baci

et al. 2023

IJMS

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Growing evidence of the microbiome’s role in human health and disease has emerged since the creation of the Human Microbiome Project. Recent studies suggest that alterations in microbiota composition (dysbiosis) may play an essential role in the occurrence, development, and prognosis of prostate cancer (PCa), which remains the second most frequent male malignancy worldwide. Current advances in biological technologies, such as high-throughput sequencing, transcriptomics, and metabolomics, have enabled research on the gut, urinary, and intra-prostate microbiome signature and the correlation with local and systemic inflammation, host immunity response, and PCa progression. Several microbial species and their metabolites facilitate PCa insurgence through genotoxin-mediated mutagenesis or by driving tumor-promoting inflammation and dysfunctional immunosurveillance. However, the impact of the microbiome on PCa development, progression, and response to treatment is complex and needs to be fully understood. This review addresses the current knowledge on the host–microbe interaction and the risk of PCa, providing novel insights into the intraprostatic, gut, and urinary microbiome mechanisms leading to PCa carcinogenesis and treatment response. In this paper, we provide a detailed overview of diet changes, gut microbiome, and emerging therapeutic approaches related to the microbiome and PCa. Further investigation on the prostate-related microbiome and large-scale clinical trials testing the efficacy of microbiota modulation approaches may improve patient outcomes while fulfilling the literature gap of microbial–immune–cancer-cell mechanistic interactions.

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A cross-sectional study on gut microbiota in prostate cancer patients with prostatectomy or androgen deprivation therapy

Cited by 18 publications

References 52 publications

Exploring the Association between Gut and Urine Microbiota and Prostatic Disease including Benign Prostatic Hyperplasia and Prostate Cancer Using 16S rRNA Sequencing

Exploring the Association between Gut and Urine Microbiota and Prostatic Disease including Benign Prostatic Hyperplasia and Prostate Cancer Using 16S rRNA Sequencing

Possibilities and limitations of using low biomass samples for urologic disease and microbiome research

Microbiome and Prostate Cancer: A Novel Target for Prevention and Treatment

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