Ancient schwannoma of the pancreas mimicking a cystic tumor

Lee, Ji; Kim, Hyung L.; Jung, Jong Jae; Han, Sang Hwa; Kim, Young

doi:10.1007/s004280100492

Cited by 35 publications

(16 citation statements)

References 2 publications

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“…2,3 Rare cystic neoplasms include acinar cell cystadenocarcinomas, 4 acinar cell cystadenomas, 5 cystic endocrine tumors 6 and cystic mesenchymal tumors. 7 The differential diagnosis of pancreatic cystic neoplasms, however, also includes pancreatic ductal adenocarcinomas with cystic changes. Most of the cystic pancreatic ductal adenocarcinomas reported in the literature were poorly differentiated tumors showing pseudocystic changes.…”

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confidence: 99%

Pancreatic ductal adenocarcinomas with cystic features: neither rare nor uniform

et al. 2005

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Cystic tumors of the pancreas are uncommon but important because of their diverse pathology and biology. Their wide spectrum also includes cystic variants of otherwise solid tumors, such as cystic endocrine tumors, cystic acinar cell carcinomas and ductal adenocarcinomas with cystic changes. In this study, we screened pancreatic ductal adenocarcinomas and their variants for macrocystic changes and determined the nature of the cysts (neoplastic vs non-neoplastic). Of 483 tumors 38 (8%) had cystic features. The largest group consisted of 24 pancreatic ductal adenocarcinomas showing a large-gland pattern with small cysts whose diameter varied between 0.5 and 1.8 cm. The epithelial lining of these cysts was generally positive for CEA (83%) and/or MUC1 (71%) and MUC5AC (74%). p53 was positive in 57% of the cases. The second group of cystic tumors (8/483) showed degenerative cystic cavities with diameters ranging between 1 and 6 cm. This group consisted of poorly differentiated pancreatic ductal adenocarcinomas, undifferentiated carcinomas with or without osteoclast-like giant cells and one adenosquamous carcinoma. In the third group of cystic tumors there were four pancreatic ductal adenocarcinomas containing tumor-related retention cysts. Their epithelial cells were positive for MUC5AC, but negative for CEA, MUC1 and p53. The fourth group consisted of two pancreatic ductal adenocarcinomas showing closely attached pseudocysts caused by tumor-associated pancreatitis. The results indicate that a considerable number of pancreatic ductal adenocarcinomas and their variants display cystic features and must therefore be considered in the differential diagnosis of cystic neoplasms of the pancreas. Moreover, not all of the cystic structures we observed were neoplastic in nature. They may also represent nonneoplastic changes, such as retention cysts and inflammatory pseudocysts.

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Pancreatic ductal adenocarcinomas with cystic features: neither rare nor uniform

et al. 2005

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“…This type of neoplasm usually consists of a cellular component (Antoni type A area) and a loose hypocellular component (Antoni type B). The cases of schwannoma displaying pronounced degenerative changes with cyst formation, calcification, hemorrhage, hyalinization and xanthomatous infiltration as demonstrated in the described case here are called ancient schwannoma [9]. Degenerative nuclear atypia is also another peculiar finding.…”

Section: Discussionmentioning

confidence: 90%

Giant ancient schwannoma of pancreatic head treated by extended pancreatoduodenectomy

et al. 2004

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“…[2][3][4][5][6] Rarer cystic neoplasms include acinar cell cystadenocarcinoma, 9 acinar cell cystadenoma, 10 cystic neuroendocrine tumor 11 and cystic mesenchymal tumor. 12 However, it should always be borne in mind that the differential diagnoses of cystic neoplasms of the pancreas should also include PDA with cystic change.…”

Section: Discussionmentioning

confidence: 99%

Pancreatic ductal adenocarcinomas with multiple large cystic structures: A clinicopathologic and immunohistochemical study of seven cases

et al. 2013

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Ancient schwannoma of the pancreas mimicking a cystic tumor

Cited by 35 publications

References 2 publications

Pancreatic ductal adenocarcinomas with cystic features: neither rare nor uniform

Pancreatic ductal adenocarcinomas with cystic features: neither rare nor uniform

Giant ancient schwannoma of pancreatic head treated by extended pancreatoduodenectomy

Pancreatic ductal adenocarcinomas with multiple large cystic structures: A clinicopathologic and immunohistochemical study of seven cases

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