Ancient origin of the integrin-mediated adhesion and signaling machinery

Sebé-Pedrós, Arnau; Roger, Andrew J.; Lang, Franz; King, Nicole; Ruiz‐Trillo, Iñaki

doi:10.1073/pnas.1002257107

Cited by 225 publications

(288 citation statements)

References 66 publications

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“…For instance, centrioles and cilia are entirely missing in Filasteria and Nucleariida, which use actin-based filopodia to crawl along a substrate (figure 1) [45,51,52,55,56,63]. A possible scenario is that the last common ancestor of all Amorphea or even of all eukaryotes was capable of both flagellar and actin-based motility, and different lineages lost one or the other (or both) while adapting to their specific environment [26,27,[64][65][66]. It is thus necessary when attempting to reconstitute the evolutionary history of the microtubule cytoskeleton to consider these aspects as well.…”

Section: Evolution Of Cytoskeleton Architecture In Amorpheamentioning

confidence: 99%

Exploring the evolutionary history of centrosomes

Azimzadeh

2014

Phil. Trans. R. Soc. B

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The centrosome is the main organizer of the microtubule cytoskeleton in animals, higher fungi and several other eukaryotic lineages. Centrosomes are usually located at the centre of cell in tight association with the nuclear envelope and duplicate at each cell cycle. Despite a great structural diversity between the different types of centrosomes, they are functionally equivalent and share at least some of their molecular components. In this paper, we explore the evolutionary origin of the different centrosomes, in an attempt to understand whether they are derived from an ancestral centrosome or evolved independently from the motile apparatus of distinct flagellated ancestors. We then discuss the evolution of centrosome structure and function within the animal lineage.

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Section: Evolution Of Cytoskeleton Architecture In Amorpheamentioning

confidence: 99%

Exploring the evolutionary history of centrosomes

Azimzadeh

2014

Phil. Trans. R. Soc. B

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“…UNICORN is obtaining the genome sequence of several holozoans and holomycots, with the aim to better understand the origins of both fungi and animals. A first look at what this data can show us is provided by the analysis of the integrin-mediated signalling and adhesion machinery that conclusively shows that choanoflagellates (and fungi) have suffered some lineage-specific gene losses of this important machinery (Sebe´-Pedro´s et al, 2010). This should be taken as a cautionary tale, because gene loss is undoubtedly an important, and sometimes neglected, player in evolutionary history and that broad taxonomic sampling is critical in comparative genomic analyses.…”

Section: Opisthokonts An Evolutionary Window To Understanding the Unmentioning

confidence: 99%

Animals and Their Unicellular Ancestors

Paps¹,

Ruiz‐Trillo²

2010

Encyclopedia of Life Sciences

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Animals belong to the Opisthokonta, one of the major divisions of the eukaryotic Tree of Life. This supergroup also includes other well‐known groups such as fungi and choanoflagellates, in addition to some newly discovered unicellular taxa as the Ichthyosporea or the Filasterea. To unveil the origin of animal multicellularity, it is vital to understand the evolution of their single‐celled relatives, as they might hold key genetic clues that might help us understand how the unicellular ancestors of animals became animals. Our current knowledge of unicellular animal relatives, their specific phylogenetic relationships and the role they might play in future research is being improved, thanks to molecular data. Key Concepts: Animals are members of the opisthokonts. The Opisthokonta clade includes animals, fungi and several unicellular lineages. Choanoflagellates are the closest animal unicellular relatives. Ichthyosporea and Filasterea lineages are most closely related to animals than to fungi. The opisthokonts include several multicellular types. The opisthokont is a key evolutionary window to understand the unicellular to multicellular transition.

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“…To further explore the origin of the Ca 2+ signaling machinery, we have more recently reported the examination of several genomes at the Origins of Multicellularity Database [14,15], the Broad Institute and the NCBI genomic databases including the genomes of three basal fungi Allomyces macrogynus, Spizellomyces punctatus, and Batrachochytrium dendrobatidis [16]. Surprisingly, our analysis revealed the presence of P2X receptor homologs in the three basal fungi (AmaP2X, SpuP2X, and BdeP2X) ( Fig.…”

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confidence: 88%

P2X receptor homologs in basal fungi

Cai

2011

Purinergic Signalling

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P2X receptors are ligand-gated ion channels that induce the flux of cations across the membrane when activated by ATP, resulting in membrane depolarization and Ca 2+ entry [1][2][3][4]. In mammals, P2X receptors have been shown to play a critical role in regulating physiological processes in a wide range of cell types such as neurons, glial cells, muscle, endothelial and epithelial cells, osteoclasts, and hematopoietic cells [1,3]. The cloning of the first P2X receptor P2X 1 in 1994 revealed an unusual structure of P2X receptors containing two transmembrane segments [5,6], which is distinct from other ionotropic receptors such as glutamate receptors and acetylcholine receptors [3]. P2X receptors appear to be present in all vertebrate and many invertebrate genomes but are absent in some invertebrates such as Caenorhabditis elegans and Drosophila melanogaster [4,7,8]. It should be noted that C. elegans and D. melanogaster are also known to lack two other Ca 2+ -permeable channelsthe voltage-gated CatSper Ca 2+ channels at the plasma membrane [9] and the two-pore channels underlying NAADP-sensitive Ca 2+ release from acidic Ca 2+ stores [10].ATP is widely utilized as an energy source in many organisms, and so, ATP could serve as an evolutionarily conserved means to mediate cell-cell communications or intracellular signaling through P2X receptors. The emergence of purinergic signaling by P2X receptors is believed to have occurred in early evolution of eukaryotes [4,8], which is supported by the identification and characterization of P2X receptor homologs in non-metazoan organisms such as the dictyostelid social amoeba Dictyostelium discoideum [11], the green alga Ostreococcus tauri [12], and the choanoflagellate Monosiga brevicollis, one of the closet unicellular relatives of animals [12,13]. Interestingly, even though a P2X receptor homolog is characterized in D. discoideum [11], P2X receptor homologs have not been detected in known genomes of fungal species [4,8]. It is generally believed that P2X receptors had been lost in fungi [4,8].We have recently demonstrated in the choanoflagellate M. brevicollis the presence of extensive Ca 2+ signaling and amplification pathways, most of which are previously believed to be animal specific [13]. To further explore the origin of the Ca 2+ signaling machinery, we have more recently reported the examination of several genomes at the Origins of Multicellularity Database [14,15], the Broad Institute and the NCBI genomic databases including the genomes of three basal fungi Allomyces macrogynus, Spizellomyces punctatus, and Batrachochytrium dendrobatidis [16]. Surprisingly, our analysis revealed the presence of P2X receptor homologs in the three basal fungi (AmaP2X, SpuP2X, and BdeP2X) ( Fig. 1; Electronic supplementary Electronic supplementary material The online version of this article

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Ancient origin of the integrin-mediated adhesion and signaling machinery

Cited by 225 publications

References 66 publications

Exploring the evolutionary history of centrosomes

Exploring the evolutionary history of centrosomes

Animals and Their Unicellular Ancestors

P2X receptor homologs in basal fungi

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