Exploring the evolutionary history of centrosomes

Azimzadeh, Juliette

doi:10.1098/rstb.2013.0453

Cited by 57 publications

(77 citation statements)

References 143 publications

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“…It is worth mentioning that MCCs are also found outside of animals in phyla as diverse as plants, ciliates, or amoebozoa (Tamm et al 1975;Mikrjukov and Mylnikov 1998;Hodges et al 2010). This distribution is most likely the result of convergent evolution, however, because these phyla originate from distinct mono-or biflagellated unicellular ancestors (Adl et al 2012;Azimzadeh 2014). mammalian respiratory system.…”

Section: Multiciliated Epithelia Across Animalsmentioning

confidence: 99%

Multiciliated Cells in Animals

Meunier¹,

Azimzadeh²

2016

Cold Spring Harb Perspect Biol

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Many animal cells assemble single cilia involved in motile and/or sensory functions. In contrast, multiciliated cells (MCCs) assemble up to 300 motile cilia that beat in a coordinate fashion to generate a directional fluid flow. In the human airways, the brain, and the oviduct, MCCs allow mucus clearance, cerebrospinal fluid circulation, and egg transportation, respectively. Impairment of MCC function leads to chronic respiratory infections and increased risks of hydrocephalus and female infertility. MCC differentiation during development or repair involves the activation of a regulatory cascade triggered by the inhibition of Notch activity in MCC progenitors. The downstream events include the simultaneous assembly of a large number of basal bodies (BBs)-from which cilia are nucleated-in the cytoplasm of the differentiating MCCs, their migration and docking at the plasma membrane associated to an important remodeling of the actin cytoskeleton, and the assembly and polarization of motile cilia. The direction of ciliary beating is coordinated both within cells and at the tissue level by a combination of planar polarity cues affecting BB position and hydrodynamic forces that are both generated and sensed by the cilia. Herein, we review the mechanisms controlling the specification and differentiation of MCCs and BB assembly and organization at the apical surface, as well as ciliary assembly and coordination in MCCs.

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Section: Multiciliated Epithelia Across Animalsmentioning

confidence: 99%

Multiciliated Cells in Animals

Meunier¹,

Azimzadeh²

2016

Cold Spring Harb Perspect Biol

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“…Interestingly, despite the limited sequence similarity between CeSAS-6 and its homologues [24,39,40], both the overall SAS-6 architecture of a globular N-terminal domain succeeded by a coiled coil and the tertiary structure of the N-terminal domain itself were highly similar. Rather, the discrepancy of SAS-6 oligomeric architecture between C. elegans and other organisms appears to originate at the protein region connecting the N-terminal domain and the coiled coil, known as the hinge (Figures 1 and 5).…”

Section: Sas-6 Spiralsmentioning

confidence: 99%

“…Genetic and functional studies in Caenorhabditis elegans aiming to isolate spindle assembly-defective mutants originally identified five proteins, SAS-6, SAS-4, SAS-5, SPD-2 and ZYG-1, essential for centriole formation [15][16][17][18][19][20][21][22]; relatives of these proteins were quickly located across eukaryotic evolution [23,24]. SAS-6 was perceived as a key protein for centriole symmetry, as immunolocalisation electron microscopy and sub-diffraction fluorescence microscopy studies placed this protein in cartwheels [25][26][27].…”

Section: Introductionmentioning

confidence: 99%

Coupling Form and Function: How the Oligomerisation Symmetry of the SAS-6 Protein Contributes to the Architecture of Centriole Organelles

2017

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Centrioles make up the centrosome and basal bodies in animals and as such play important roles in cell division, signalling and motility. They possess characteristic 9-fold radial symmetry strongly influenced by the protein SAS-6. SAS-6 is essential for canonical centriole assembly as it forms the central core of the organelle, which is then surrounded by microtubules. SAS-6 self-assembles into an oligomer with elongated spokes that emanate towards the outer microtubule wall; in this manner, the symmetry of the SAS-6 oligomer influences centriole architecture and symmetry. Here, we summarise the form and symmetry of SAS-6 oligomers inferred from crystal structures and directly observed in vitro. We discuss how the strict 9-fold symmetry of centrioles may emerge, and how different forms of SAS-6 oligomers may be accommodated in the organelle architecture.

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“…In recent years, proteomic analyses (Andersen, Wilkinson, & Mayor, 2003;Keller, Romijn, Zamora, Yates, & Marshall, 2005;Müller et al, 2010), comparative genomics (Avidor-reiss et al, 2004;Azimzadeh, 2014;Li et al, 2004), and loss of function studies (Alves-Cruzeiro, Nogales-Cadenas, & Pascual-Montano, 2014) have identified a large inventory of proteins involved in different facets of centrosome function. With this new wealth of information, a complex and more realistic picture of the centrosome's role in cells is emerging.…”

Section: Introductionmentioning

confidence: 98%