AnchorSeed for the reduction of source movement in prostate brachytherapy with the Mick applicator implant technique

Badwan, Hamzeh O.; Shanahan, Angela E.; Adams, Mark; Shanahan, Thomas G.; Mueller, Paul W.; Markwell, Stephen; Tarter, Thomas H.

doi:10.1016/j.brachy.2009.07.002

Cited by 9 publications

(4 citation statements)

References 17 publications

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“…36 For clinical implementation, a biocompatible coating with similar optical absorption to India ink would be more suitable, which is a reasonable modification for seeds purposely designed for photoacoustic imaging considering that similar enhancement coatings are common in brachytherapy. 37 After placing the catheter and probe in their respective holes, the side-firing fiber was inserted through the urinary catheter and rotated to visualize each seed individually, as illustrated in Fig. 3(a).…”

Section: Phantom Experimentsmentioning

confidence: 99%

Transurethral light delivery for prostate photoacoustic imaging

et al. 2015

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Abstract. Photoacoustic imaging has broad clinical potential to enhance prostate cancer detection and treatment, yet it is challenged by the lack of minimally invasive, deeply penetrating light delivery methods that provide sufficient visualization of targets (e.g., tumors, contrast agents, brachytherapy seeds). We constructed a sidefiring fiber prototype for transurethral photoacoustic imaging of prostates with a dual-array (linear and curvilinear) transrectal ultrasound probe. A method to calculate the surface area and, thereby, estimate the laser fluence at this fiber tip was derived, validated, applied to various design parameters, and used as an input to three-dimensional Monte Carlo simulations. Brachytherapy seeds implanted in phantom, ex vivo, and in vivo canine prostates at radial distances of 5 to 30 mm from the urethra were imaged with the fiber prototype transmitting 1064 nm wavelength light with 2 to 8 mJ pulse energy. Prebeamformed images were displayed in real time at a rate of 3 to 5 frames per second to guide fiber placement and beamformed offline. A conventional delay-and-sum beamformer provided decreasing seed contrast (23 to 9 dB) with increasing urethra-to-target distance, while the shortlag spatial coherence beamformer provided improved and relatively constant seed contrast (28 to 32 dB) regardless of distance, thus improving multitarget visualization in single and combined curvilinear images acquired with the fiber rotating and the probe fixed. The proposed light delivery and beamforming methods promise to improve key prostate cancer detection and treatment strategies.

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Section: Phantom Experimentsmentioning

confidence: 99%

Transurethral light delivery for prostate photoacoustic imaging

et al. 2015

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“…Thus, we can conclude that a strand with helical grooves on its surface possesses a larger area than a smooth strand and will subsequently experience higher resistance to motion, a conclusion that is consistent with results shown in Table 1. It can be inferred, therefore, that a seed implant that has grooves on its surface will have a larger area than a smooth strand and will be less susceptible to migration after the implantation, which was also reported by Badwan et al [22].…”

Section: Discussionmentioning

confidence: 71%

The fixity of prostate seed implants: The impact of the strand surface on its ability to migrate inside oil and gel medium

2015

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“…The coating is sufficiently thin to permit the seeds to be used in a standard Mick ® applicator and needle (Mick Radio‐Nuclear Instruments, Inc., Bronx, NY, USA). It has previously been shown that such a coating improves the fixity of seeds in that it reduces their movement within the target region, preserving target coverage and organ at risk (OAR) sparing 7. The present study quantifies the incidence of local initial movement (slippage) of seeds as visualized in real‐time ultrasound imaging with a proprietary braided coating in comparison with uncoated seeds with a Mick ® applicator technique.…”

Section: Introductionmentioning

confidence: 96%

“…Placement of seeds into unintended positions may negatively affect real‐time and postimplant dosimetry, and suboptimal seed fixity may increase the incidence of seeds dislodging into adjacent blood vessels,6 where they may be transported by blood flow to distant anatomical sites, such as the lungs, heart, and other organs. It is, therefore, desirable to minimize seed slippage and movement in the PPB procedure 7, 8, 9, 10…”

Section: Introductionmentioning

confidence: 99%

Reduction of seed motion using a bio‐absorbable polymer coating during permanent prostate brachytherapy using a mick applicator technique

Warrell

Xing

Podder

et al. 2018

J Applied Clin Med Phys

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PurposeThe addition of a braided bio‐absorbable vicryl coating to the surface of radioactive seeds used for low dose rate (LDR) prostate brachytherapy is intended to reduce the incidence of seed movement and migration. Here, we present a single‐institution study of the frequency and severity of seed slippage (initial seed movement) of coated seeds in comparison with uncoated seeds.MethodsForty‐seven patients received permanent prostate brachytherapy, with either coated (n = 26) or uncoated (n = 21) seeds. AgX100 125I seeds, coated or uncoated, and uncoated Model 200 103Pd seeds were used. During the ultrasound‐guided implantation procedure, each implanted seed was categorized as having remained in the implanted position after being placed, having moved slightly, or having left the ultrasound field of view.Results3.1% of the coated seeds (AgX100 seeds, n = 70) and 6.9% of the uncoated seeds (AgX100 and Model 200 seeds, n = 128) were observed to have moved at least 2 mm from their initial implant positions, respectively. The difference in incidence of this movement was 54.4% (P = 0.0026). Coated AgX100 seeds demonstrated a 66.7% lower rate of movement of at least 2 mm than that for uncoated AgX100 seeds (P = 0.038), and a 49.0% lower rate than that for Model 200 seeds (P = 0.021). While no significant differences were noted in prescription dose coverage of the prostate or the studied dosimetric parameters for the organs at risk between the coated and uncoated seeds (P > 0.05) in the CT‐based Day‐0 postoperative plans, the limited sample size and differences in energies between the 125I and 103Pd seeds make further analysis of postoperative dosimetric coverage difficult without additional data directly comparing the coated and uncoated 125I seeds.ConclusionWhen the vicryl coating is used, seeds have a significantly lower propensity to slip from their initial implant locations. This may help maintain dosimetric integrity, warranting further study of postoperative dosimetry.

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AnchorSeed for the reduction of source movement in prostate brachytherapy with the Mick applicator implant technique

Cited by 9 publications

References 17 publications

Transurethral light delivery for prostate photoacoustic imaging

Transurethral light delivery for prostate photoacoustic imaging

The fixity of prostate seed implants: The impact of the strand surface on its ability to migrate inside oil and gel medium

Reduction of seed motion using a bio‐absorbable polymer coating during permanent prostate brachytherapy using a mick applicator technique

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