Ancel Keys Lecture.

Rose, Guy De

doi:10.1161/01.cir.84.3.1405

Cited by 33 publications

(13 citation statements)

References 6 publications

(1 reference statement)

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“…5 In the case of BMI, however, the distributions of BMI in the populations with higher values were not only shifted upward but also tended to become more skewed. 6 This increasing skewness is similar to that seen in the NHANES data for adults, where small increases in mean and median BMI values are accompanied by greater than expected increases in the prevalence of high values because of the increasing skewness.…”

Section: Discussionsupporting

confidence: 79%

Changes in the distribution of body mass index of adults and children in the US population

2000

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BACKGROUND: National survey data show increases in mean body mass index (BMI) and in the prevalence of overweight and obesity for adults and children in the United States, indicating a change in the distribution of BMI. OBJECTIVE: To apply graphical methods to describe changes in the distribution of BMI. DESIGN: BMI values from the third National Health and Nutrition Examination Survey (NHANES III: 1988 ± 94) were compared with data from earlier cross-sectional nationally representative surveys for adults 20 ± 74 y of age and for children and adolescents 6 ± 17 y of age. Tukey mean ± difference plots were used to investigate the changes in the distributions of BMI within sex ± age groups. RESULTS: Mean ± difference plots allow qualitative visual comparisons of the distributions of BMI between surveys. For all sex ± age groups, there was increasing skewness with a greater shift in the upper part of the distribution so that, within each group, the heaviest subgroup was heavier in NHANES III than in prior surveys. For the youngest children, the lower part of the distribution showed virtually no change. With increasing age the whole distribution tended to shift upward slightly, suggesting an increase in BMI across the entire population. CONCLUSIONS: These changes in the distribution of BMI suggest the combination of both profound environmental determinants and a population with a high degree of susceptibility. The reasons for the increasing prevalence of obesity should be sought in part by seeking to understand the factors causing increases in the population as a whole.

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Section: Discussionsupporting

confidence: 79%

Changes in the distribution of body mass index of adults and children in the US population

2000

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“…The findings confirmed the close link between population mean and prevalence of deviance, in support of Rose's (1991Rose's ( , p. 1408) conclusion, 'The population mean predicts the number of deviant individuals'. Our findings also revealed that his model on the relation between the mean population value for BMI and the prevalence of obesity can be extended to include the relation between the mean population values for BMI and the prevalence of thinness.…”

Section: Discussionsupporting

confidence: 83%

“…Thinness affected the whole population as evidenced by changes in the distribution of BMI occurring across the entire BMI spectrum. As Rose's (1991Rose's ( , p. 1408 model proposed, 'the way most children eat and behave, even if it were harmless to themselves, may determine how many others, more vulnerable, will suffer as a consequence'. Copyright of Annals of Human Biology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission.…”

Section: Discussionmentioning

confidence: 99%

Trends in thin body stature among Japanese male adolescents, 2003–2012

Inokuchi

Matsuo

Takayama³

et al. 2013

Annals of Human Biology

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“…Absolute rather than relative risk is preferred for the purposes of cardiovascular risk prediction because absolute risk determines the absolute benefit and therefore the costeffectiveness and risk-benefit balance of any preventative intervention. 31 Thus, the combination of a likely homogeneous relative association of CRP with cardiovascular events across populations, but the different absolute values of CRP and absolute risks of cardiovascular events in the different ethnic/ancestral groups, means that a single universal CRP threshold for the designation of high risk individuals will capture a different proportion of the adult population, depending on their ancestral origin.…”

Section: Shah Et Al Ancestry Crp and Cardiovascular Risk Predictionmentioning

confidence: 99%

Ancestry as a Determinant of Mean Population C-Reactive Protein Values

Shah

Newcombe

Smeeth

et al. 2010

Circ Cardiovasc Genet

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Background-EligibilityDifferences were not explained by study design or CRP assay and were preserved after adjustment for age and body mass index. At age 60 years, fewer than half of East Asians but more than two thirds of Hispanics were estimated to have CRP values exceeding 2 mg/L. HapMap frequencies of CRP polymorphisms known to associate with CRP concentration but not coronary heart disease events differed by ancestry. In participant data from the Wandsworth Heart and Stroke Study including European, South Asian and African, and Caribbean-descent subjects, body mass index, systolic blood pressure, and smoking contributed to between-group differences in CRP, but the majority of the difference in CRP was unexplained. Conclusions-Differences in CRP concentration in populations of diverse ancestry are sufficiently large to affect statin eligibility, based on a single CRP threshold of 2 mg/L, and only partially influenced by differences in variables related to cardiovascular risk. A single threshold value of CRP for cardiovascular risk prediction could lead to inequalities in statin eligibility that may not accurately reflect underlying levels of cardiovascular risk. (Circ Cardiovasc Genet. 2010;3:436-444.)

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Ancel Keys Lecture.

Cited by 33 publications

References 6 publications

Changes in the distribution of body mass index of adults and children in the US population

Changes in the distribution of body mass index of adults and children in the US population

Trends in thin body stature among Japanese male adolescents, 2003–2012

Ancestry as a Determinant of Mean Population C-Reactive Protein Values

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