Anatomy of executive deficit following ruptured anterior communicating artery aneurysm

Martinaud, Olivier; Perin, Benjamin; Gérardin, Emmanuel; Proust, F.; Bioux, Sandrine; Gars, D. Le; Hannequin, Didier; Godefroy, Olivier

doi:10.1111/j.1468-1331.2009.02546.x

Cited by 61 publications

(43 citation statements)

References 37 publications

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Section: Introductionsupporting

confidence: 69%

“…The ventral striatum has long been a candidate structure for addiction vulnerability given its central role in salience-processing, reward-learning, acute response to illicit drugs and alcohol, and demonstrated abnormalities in addicted populations (Koob and Volkow, 2010). The left ventral striatum also contributes to Go/No-Go performance in a manner sensitive to FHP (Heitzeg et al, 2010), consistent with findings suggesting a role for the left ventral striatum in hyperactive behaviors (Martinaud et al, 2009).To account for impulsivity's multi-factorial nature and the relevance of related constructs to addiction vulnerability, extensive out-of-scanner measures assessing impulsivity and related constructs (reward and punishment sensitivity, attention, compulsivity, risk-taking, sensationseeking) were consolidated into five factors, based on a previously published factor analysis (Meda et al, 2009). Measures of age of drinking onset and past-month alcohol consumption were explored in relation to regional FHPrelated differences in BOLD signal and impulsivity-related factors.…”

supporting

confidence: 68%

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Neural Correlates of Impulsivity in Healthy Males and Females with Family Histories of Alcoholism

DeVito

Meda

Jiantonio

et al. 2013

Neuropsychopharmacol

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Individuals family-history positive (FHP) for alcoholism have increased risk for the disorder, which may be mediated by intermediate behavioral traits such as impulsivity. Given the sex differences in the risk for and clinical presentation of addictive disorders, risk for addiction may be differentially mediated by impulsivity within FHP males and females. FHP (N ¼ 28) and family-history negative (FHN, N ¼ 31) healthy, non-substance-abusing adults completed an fMRI Go/No-Go task and were assessed on impulsivity and alcohol use. Effects of family history and sex were investigated as were associations between neural correlates of impulse control and out-ofscanner measures of impulsivity and alcohol use. FHP individuals showed greater activation in the left anterior insula and inferior frontal gyrus during successful inhibitions, an effect that was driven primarily by FHP males. Higher self-reported impulsivity and behavioral discounting impulsivity, but not alcohol use measures, were associated with greater BOLD signal in the region that differentiated the FHP and FHN groups. Impulsivity factors were associated with alcohol use measures across the FHP and FHN groups. These findings are consistent with increased risk for addiction among FHP individuals being conferred through disrupted function within neural systems important for impulse control. Keywords: impulsivity; family history of alcoholism; insula; inferior frontal gyrus (IFG); addiction; sex differences. INTRODUCTIONAlcohol use disorders (AUDs) are prevalent and associated with detrimental health and societal outcomes (Li, 2008). Individuals with a family history of alcoholism (familyhistory positive (FHP)) have increased risk for alcoholism driven by genetic and environmental factors (Lieb et al, 2002;Slutske et al, 2002). Healthy FHPs model addiction vulnerability without confounding effects of excess alcohol on cognition and brain function.Increased AUD risk among FHPs may be conferred via heritable impulsive tendencies (Dick et al, 2010;Tessner and Hill, 2010). Impulsivity is a multi-factorial construct, where distinct sub-components appear to have differential neural bases and relationships with addiction (de Wit, 2009;Lejuez et al, 2010;Rogers et al, 2010). Aspects of impulsivity may both predispose to and be exacerbated by addictive behaviors. Impulsivity predicts development of AUDs; is higher in FHPs with more alcohol-dependent relatives (ie higher family-history load); and partially mediates the relationship between FHP and alcohol and substance use disorder (for review, see de Wit, 2009;Dick et al, 2010;Lejuez et al, 2010;Verdejo-Garcia et al, 2008). Other less well-studied impulsivity-related constructs (eg, sensationseeking, risk-taking, compulsivity, behavioural activation/ inhibition, reward/punishment sensitivity) have been related to addiction vulnerability, and addictions therefore warrant consideration (eg, Meda et al, 2009).Sex differences are important to consider as they are observable for rates, clinical presentation, and health cons...

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Section: Introductionsupporting

confidence: 69%

supporting

confidence: 68%

Neural Correlates of Impulsivity in Healthy Males and Females with Family Histories of Alcoholism

DeVito

Meda

Jiantonio

et al. 2013

Neuropsychopharmacol

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“…31,32 Third, cognitive deficits have been strongly correlated to hippocampal CA1 neuronal cell number after experimental SAH. 15 To be sure, other structural areas may also play a role, including left hemispheric lesions, 33 reductions in total gray and white matter volume 34 (in patients), and cortical neuronal cell loss (in rats). 15 In total, these data provide substantial evidence that hippocampal damage plays a key role in SAH-induced cognitive deficits, but that alterations in other brain areas also contribute.…”

Section: Discussionmentioning

confidence: 99%

Endovascular Perforation Subarachnoid Hemorrhage Fails to Cause Morris Water Maze Deficits in the Mouse

Holtzman

Friess

Hartman

et al. 2014

J Cereb Blood Flow Metab

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Cognitive dysfunction is the primary driver of poor long-term outcome in aneurysmal subarachnoid hemorrhage (SAH) survivors; modeling such deficits preclinically is thus key for mechanistic and translational investigation. Although rat SAH causes long-term deficits in learning and memory, it remains unknown whether similar deficits are seen in the mouse, a species particularly amenable to powerful, targeted genetic manipulation. We thus subjected mice to endovascular perforation SAH and assessed long-term cognitive outcome via the Morris water maze (MWM), the most commonly used metric for rodent neurocognition. No significant differences in MWM performance (by either of two protocols) were seen in SAH versus sham mice. Moreover, SAH caused negligible hippocampal CA1 injury. These results undercut the potential of commonly used methods (of SAH induction and assessment of long-term neurocognitive outcome) for use in targeted molecular studies of SAH-induced cognitive deficits in the mouse.

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“…Consequently, the prevalence of executive dysfunction in aSAH survivors is very wide with estimates ranging from 3% to 76%. 10,[12][13][14][15][16][17][18][19]37 Interestingly, self-reported deficits in executive function do not appear to correlate with results from objective cognitive tests; Ravnik and colleagues 38 found that patients with aSAH reported attentional deficits most frequently, yet patients performed better on tests of attention than on tests of other cognitive domains. Discordance between self-reported cognitive deficits and results from objective cognitive tests has also been reported in other domains, like memory.…”

Section: Executive Functionmentioning

confidence: 99%

“…An MRI study by Martinaud and colleagues, 15 for instance, suggested that executive dysfunction results from focal lesions rather than diffuse damage. Martinaud and colleagues 15 showed that executive dysfunction in patients with aSAH was exclusively correlated with lesions to the left hemisphere.…”

Section: Executive Functionmentioning

confidence: 99%

Cognitive and Functional Outcome After Aneurysmal Subarachnoid Hemorrhage

Al-Khindi

Macdonald

Schweizer

2010

Stroke

647

478

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Background and Purpose-Aneurysmal subarachnoid hemorrhage (aSAH) is a medical emergency characterized by the accumulation of blood in the subarachnoid space surrounding the brain. The acute treatment of aSAH is well documented but less is known about the long-term effects of aSAH on cognition and day-to-day functioning. Methods-We reviewed all studies in the past 10 years that have focused on the effects of aSAH on cognition and day-to-day functioning. Results-Sixty-one empirical studies examining cognitive and functional outcome in patients with aSAH met inclusion criteria. Survivors of aSAH commonly experience deficits in memory, executive function, and language. These cognitive impairments interact to affect patients' day-to-day functioning, including activities of daily living, instrumental activities of daily living, return to work, and quality of life. Deficits in cognition and day-to-day functioning are further compounded by depression, anxiety, fatigue, and sleep disturbances. Conclusions-Much remains to be learned about the brain changes underlying cognitive and functional deficits, including the role of diffuse brain damage and secondary complications like vasospasm and elevated intracranial pressure. A consideration of these issues is necessary to obtain a better understanding of how aSAH affects cognition and day-to-day functioning in the long-term. (Stroke. 2010;41:e519-e536.)

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Anatomy of executive deficit following ruptured anterior communicating artery aneurysm

Abstract: This study supports that (i) cognitive executive deficits depend mostly on lateral prefrontal lesions, (ii) with locations varying according to executive process, and (iii) behavioral executive deficits are mainly due to left ventral striatum lesion in post-aneurysmal damage.

Cited by 61 publications

References 37 publications

Neural Correlates of Impulsivity in Healthy Males and Females with Family Histories of Alcoholism

Neural Correlates of Impulsivity in Healthy Males and Females with Family Histories of Alcoholism

Endovascular Perforation Subarachnoid Hemorrhage Fails to Cause Morris Water Maze Deficits in the Mouse

Cognitive and Functional Outcome After Aneurysmal Subarachnoid Hemorrhage

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