Anatomy and White Matter Connections of the Lingual Gyrus and Cuneus

Palejwala, Ali H.; Dadario, Nicholas B.; Young, Isabella M.; O’Connor, Kyle P.; Briggs, Robert G.; Conner, Andrew K.; O’Donoghue, Daniel L.; Sughrue, Michael E.

doi:10.1016/j.wneu.2021.04.050

Cited by 104 publications

(72 citation statements)

References 41 publications

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“…In addition, we found that the RDE group had higher ALFF values in the right lingual gyrus than the FDE group. The lingual gyrus is part of the occipital lobe, and previous studies have shown that the lingual gyrus is also involved in activities related to visual memory processing and is closely associated with the development of MDD ( Jung et al, 2014 ; Le et al, 2017 ; Palejwala et al, 2021 ). One study found that patients with rMDD had lower ALFF values in the right lingual gyrus than HCs, suggesting that reduced ALFF in the right lingual gyrus is a marker for the remission of depression ( Yang et al, 2018 ).…”

Section: Discussionmentioning

confidence: 99%

Altered Brain Function in First-Episode and Recurrent Depression: A Resting-State Functional Magnetic Resonance Imaging Study

Sun

Chen

et al. 2022

Front. Neurosci.

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BackgroundStudies on differences in brain function activity between the first depressive episode (FDE) and recurrent depressive episodes (RDE) are scarce. In this study, we used regional homogeneity (ReHo) and amplitude of low-frequency fluctuations (ALFF) as indices of abnormal brain function activity. We aimed to determine the differences in these indices between patients with FDE and those with RDE, and to investigate the correlation between areas of abnormal brain function and clinical symptoms.MethodsA total of 29 patients with RDE, 28 patients with FDE, and 29 healthy controls (HCs) who underwent resting-state functional magnetic resonance imaging were included in this study. The ReHo and ALFF measurements were used for image analysis and further analysis of the correlation between different brain regions and clinical symptoms.ResultsAnalysis of variance showed significant differences among the three groups in ReHo and ALFF in the frontal, parietal, temporal, and occipital lobes. ReHo was higher in the right inferior frontal triangular gyrus and lower in the left inferior temporal gyrus in the RDE group than in the FDE group. Meanwhile, ALFF was higher in the right inferior frontal triangular gyrus, left anterior cingulate gyrus, orbital part of the left middle frontal gyrus, orbital part of the left superior frontal gyrus, and right angular gyrus, but was lower in the right lingual gyrus in the RDE group than in the FDE group. ReHo and ALFF were lower in the left angular gyrus in the RDE and FDE groups than in the HC group. Pearson correlation analysis showed a positive correlation between the ReHo and ALFF values in these abnormal areas in the frontal lobe and the severity of depressive symptoms (P < 0.05). Abnormal areas in the temporal and occipital lobes were negatively correlated with the severity of depressive symptoms (P < 0.05).ConclusionThe RDE and FDE groups had abnormal neural function activity in some of the same brain regions. ReHo and ALFF were more widely distributed in different brain regions and had more complex neuropathological mechanisms in the RDE group than in the FDE group, especially in the right inferior frontal triangular gyrus of the frontal lobe.

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Section: Discussionmentioning

confidence: 99%

Altered Brain Function in First-Episode and Recurrent Depression: A Resting-State Functional Magnetic Resonance Imaging Study

Sun

Chen

et al. 2022

Front. Neurosci.

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“…Convergent evidence suggests that the amygdala is responsible for crucial functions related to depression including the processing of visual information elicited by emotional stimuli ( 51 ). The cuneus is located in the occipital lobe and is mainly involved in the processing of visual information ( 52 ). We speculated that decreased FC between the amygdala and cuneus in state 2 might reflect bias evaluation to emotion stimuli of MDD patients when performing cognitive reappraisal.…”

Section: Discussionmentioning

confidence: 99%

Antidepressant Treatment-Induced State-Dependent Reconfiguration of Emotion Regulation Networks in Major Depressive Disorder

et al. 2022

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Deficits in emotion regulation are the main clinical features, common risk factors, and treatment-related targets for major depressive disorder (MDD). The neural bases of emotion regulation are moving beyond specific functions and emphasizing instead the integrative functions of spatially distributed brain areas that work together as large-scale brain networks, but it is still unclear whether the dynamic interactions among these emotion networks would be the target of clinical intervention for MDD. Data were collected from 70 MDD patients and 43 sex- and age-matched healthy controls. The dynamic functional connectivity (dFC) between emotion regions was estimated via a sliding-window method based on resting-state functional magnetic resonance imaging (R-fMRI). A k-means clustering method was applied to classify all time windows across all participants into several dFC states reflecting recurring functional interaction patterns among emotion regions over time. The results showed that four dFC states were identified in the emotion networks. Their alterations of state-related occurrence proportion were found in MDD and subsequently normalized following 12-week antidepressant treatment. Baseline strong dFC could predict the reduction rate of Hamilton Depression Rating Scale (HAMD) scores. These findings highlighted the state-dependent reconfiguration of emotion regulation networks in MDD patients owing to antidepressant treatment.

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“…Of the negative features we identified, the decreased functional connectivity between the right hippocampus and the lingual gyrus and the cuneus gyrus were the most prominent and stable. Both regions send and receive projections to the medial temporal lobes via the inferior longitudinal fasciculus, as demonstrated by diffusion tractography and post-mortem dissection (Palejwala et al, 2021), suggesting a role in memory. Consistent with this possibility, both structural and functional magnetic resonance imaging findings suggest that these components of the ventral visual stream play a role in recollection.…”

Section: Discussionmentioning

confidence: 99%

Reduced Hippocampal-Cortical Connectivity During Memory Suppression Predicts the Ability to Forget Unwanted Memories

Yan

Hulbert

Zhuang

et al. 2022

Preprint

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The ability to suppress unwelcome memories is important for productivity and well-being. Successful memory suppression is associated with hippocampal deactivations and a concomitant disruption of this region's functionality. Much of the previous neuroimaging literature exploring such suppression-related hippocampal modulations has focused on the region's negative coupling with the prefrontal cortex. In contrast, task-based changes in functional connectivity between the hippocampus and other brain regions have remained relatively underexplored. Here, we utilize psychophysiological interactions and seed connectome-based predictive modeling (seed-CPM) to investigate the relationship between the hippocampus and the rest of the brain as 134 participants attempted to suppress unwanted memories during the Think/No-Think task. The results show that during retrieval suppression, the right hippocampus exhibited decreased functional connectivity with visual cortical areas (bilateral intracalcarine cortex, right cuneal cortex, left lingual gyrus, right supracalcarine cortex, right occipital pole), left nucleus accumbens and the brain-stem that predicted superior forgetting of unwanted memories on later memory tests. Validation tests verified that prediction performance was not an artifact of head motion or prediction method and that the negative features remained consistent across different brain parcellations. These findings suggest that systemic memory suppression involves more than the modulation of hippocampal activity—it alters functional connectivity patterns between the hippocampus and visual cortex, leading to successful forgetting.

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Anatomy and White Matter Connections of the Lingual Gyrus and Cuneus

Cited by 104 publications

References 41 publications

Altered Brain Function in First-Episode and Recurrent Depression: A Resting-State Functional Magnetic Resonance Imaging Study

Altered Brain Function in First-Episode and Recurrent Depression: A Resting-State Functional Magnetic Resonance Imaging Study

Antidepressant Treatment-Induced State-Dependent Reconfiguration of Emotion Regulation Networks in Major Depressive Disorder

Reduced Hippocampal-Cortical Connectivity During Memory Suppression Predicts the Ability to Forget Unwanted Memories

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