Anatomical restrictions in the surgical excision of scalp squamous cell carcinomas: does this affect local recurrence and regional nodal metastases?

Jenkins, G.; Smith, Adam B.; Kanatas, Anastasios; Houghton, Douglas; Telfer, M.R.

doi:10.1016/j.ijom.2013.08.018

Cited by 18 publications

(19 citation statements)

References 20 publications

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“…Thirty‐nine studies reported on metastasis risk of cSCC in the immunocompetent population. Nineteen studies reported on special cohorts in the immunocompetent population, like specific anatomical locations or only reporting on specific high‐risk cSCC or cSCC derived in burns . The results of these specific cohorts are not taken into account in the pooled metastasis risk analyses.…”

Section: Resultsmentioning

confidence: 99%

“…Nineteen studies reported on special cohorts in the immunocompetent population, like specific anatomical locations or only reporting on specific high-risk cSCC or cSCC derived in burns. [58][59][60][61][62][63][64][65][66][67][68][69][70][71][72][73][74][75][76] The results of these specific cohorts are not taken into account in the pooled metastasis risk analyses. The details of these studies are shown in Table 2.…”

Section: Studies In Otrmentioning

confidence: 99%

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Metastasis of cutaneous squamous cell carcinoma in organ transplant recipients and the immunocompetent population: is there a difference? a systematic review and meta‐analysis

Genders

Weijns

Dekkers

et al. 2019

Acad Dermatol Venereol

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Background Organ transplant recipients (OTR) have a higher risk of developing cutaneous squamous cell carcinoma (cSCC) compared to the immunocompetent population. Immunosuppression is often stated as a risk factor for metastasis. However, evidence for this is scarce.Objectives To investigate the cSCC metastasis risk in OTR and the immunocompetent population by systematically reviewing the literature.Methods A systematic review of the literature was performed up to January 2018 using: Medline; Embase; Web of Science and ISI Science Citation Index. Studies assessing cSCC metastasis risk in ORT or immunocompetent cohorts were considered. A pooled risk estimate for metastasis was calculated for the immunocompetent population and OTR separately. ResultsThe pooled metastasis risk estimate for OTR was, respectively, 7.3% (95% CI 6.2-8.4) for cSCC on total body, and 11.0% (95% CI 7.7-14.8) for cSCC of the head neck area. For the immunocompetent population reported risk estimate analysis showed a pooled metastatic risk of 3.1% (95% CI 2.8-3.4) in total body cSCC and of 8.5% (95% CI 7.3-9.8) in cSCC of the head and neck area.Pooled risk estimate per single cSCC in OTR was 1.3% (95% CI 1.0-1.7) in total body cSCC and 4.0% (95% CI 2.7-5.5) in cSCC of the head and neck area. In the immunocompetent population, these pooled risk estimates were, respectively, 2.4% (95% CI 2.1-2.6) and 6.7% (95% CI 5.7-7.8).Conclusions Organ transplant recipients show a higher overall risk of cSCC metastasis compared to the immunocompetent population. Metastasis risks per single cSCC were substantially lower in both groups. However, due to heterogeneity and differences between studies, comparisons are difficult. Comprehensive follow-up studies with defined cohorts are necessary to adequately asses the risk for cSCC metastasis.

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Section: Resultsmentioning

confidence: 99%

Section: Studies In Otrmentioning

confidence: 99%

Metastasis of cutaneous squamous cell carcinoma in organ transplant recipients and the immunocompetent population: is there a difference? a systematic review and meta‐analysis

Genders

Weijns

Dekkers

et al. 2019

Acad Dermatol Venereol

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“…In a study of 101 excised scalp SCC, 3/37 patients developed local recurrence with a margin ≤2 mm and none with margins between 2 and 6 mm. The authors of this study suggested patients with a ≤2 mm margin be informed and followed up appropriately, although adjuvant RT was not mentioned as an option . A review of 233 scalp SCC treated at the Peter MacCallum Cancer Centre, Melbourne, documented 21 local relapses with 16/21 not receiving adjuvant RT.…”

Section: Squamous Cell Carcinomamentioning

confidence: 99%

The role of radiotherapy in the management of non‐melanoma skin cancer

Garbutcheon‐Singh

Veness

2019

Aust J Dermatology

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The global incidence of non-melanoma skin cancer continues to increase as the global population ages with the highest incidence in the world occurring in Australian and New Zealand patients. There are numerous treatment options available for non-melanoma skin cancer patients of which radiotherapy is an efficacious and versatile tissue preserving nonsurgical (or medical) option. In patients where excision may not be an option (medically/technically inoperable) or considered less ideal (e.g. cosmetic outcome), radiotherapy offers an excellent option. Following surgery, adjuvant radiotherapy in patients with unfavourable pathology can decrease the risk of recurrence and associated morbidity. Elderly and co-morbid patients with poor performance status can benefit from short-course hypofractionated radiotherapy in the setting where surgery is not an option. As with any modality, radiotherapy has advantages and disadvantages and it is therefore important for clinicians to appreciate these. We aim to present an update for clinicians that manage patients with non-melanoma skin cancer on the role of radiotherapy.

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“…A vékony dermissel és minimális subcutissal rendelkező helyeken, például a fülön, az alatta fekvő porc kimetszésére is szükség van a tumor alapon történő teljes eltávolítása érdekében. Ehhez hasonlóan a skalpon található spinaliomák kimetszésekor is rutinszerűen a galeán keresztül a periosteumig javasolt a tumort kimetszeni, hogy az alapon is az épben történjen az eltávolítás azoknál a daganatoknál, ahol klinikailag a csont és a periosteum nem érintett (32).…”

Section: Mekkora Legyen a Biztonsági Zóna?unclassified

“…Egy retrospektív megfigyeléses vizsgálat eredményei azt sugallják, hogy a szűkebb alapi szélek a recidivák kialakulásának nagyobb kockázatával társulnak, bár itt a recidivák kialakulásának egyéb (a betegből vagy a tumor sajátságaiból adódó) lehetséges okait nem vették figyelembe (32).…”

Section: Mekkora Legyen a Biztonsági Zóna?unclassified

Surgery is the first line treatment in the management of non-melanoma skin cancers

Kis¹,

Kádár²,

Juhász³

2018

BVSZ

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Anatomical restrictions in the surgical excision of scalp squamous cell carcinomas: does this affect local recurrence and regional nodal metastases?

Cited by 18 publications

References 20 publications

Metastasis of cutaneous squamous cell carcinoma in organ transplant recipients and the immunocompetent population: is there a difference? a systematic review and meta‐analysis

Metastasis of cutaneous squamous cell carcinoma in organ transplant recipients and the immunocompetent population: is there a difference? a systematic review and meta‐analysis

The role of radiotherapy in the management of non‐melanoma skin cancer

Surgery is the first line treatment in the management of non-melanoma skin cancers

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