Anatomical MRI study of hippocampus and amygdala in patients with current and remitted major depression

Caetano, Sheila C.; Hatch, John P.; Brambilla, Paolo; Sassi, Roberto; Nicoletti, Mark; Mallinger, Alan G.; Frank, Ellen; Kupfer, David J.; Keshavan, Matcheri S.; Soares, Jair C.

doi:10.1016/j.pscychresns.2004.08.002

Cited by 177 publications

(97 citation statements)

References 37 publications

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“…For example, hippocampal reduction, so frequently described in PTSD, is known to be associated with depressive signs and symptoms. 87 Another important point is the inclusion of patients currently or previously taking medications since its use such as paroxetine, among others, has been shown to affect the cerebral morphology of the patients. 35,59 Differences in age and in gender balancing also cause a lack of homogeneity between results.…”

Section: Discussionmentioning

confidence: 99%

Structural magnetic ressonance imaging in anxiety disorders: an update of research findings

Ferrari

Busatto

McGuire

et al. 2008

Rev. Bras. Psiquiatr.

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Objective: The aim of the present report is to present a systematic and critical review of the more recent literature data about structural abnormalities detected by magnetic ressonance in anxiety disorders. Method: A review of the literature in the last five years was conducted by a search of the Medline, Lilacs and SciELO indexing services using the following key words : "anxiety", "panic", "agoraphobia", "social anxiety", "posttraumatic" and "obsessive-compulsive", crossed one by one with "magnetic resonance", "voxel-based", "ROI" and "morphometry palavras-chave: "anxiety", "panic", "agoraphobia", "social anxiety", "posttraumatic" e "obsessive-compulsive" cruzadas uma a uma com "magnetic ressonance", "voxel-based", "ROI" e "morphometry

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Section: Discussionmentioning

confidence: 99%

Structural magnetic ressonance imaging in anxiety disorders: an update of research findings

Ferrari

Busatto

McGuire

et al. 2008

Rev. Bras. Psiquiatr.

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“…Specifically, perhaps the higher incidence of histories of co-morbid Axis I disorders in this female sample (17/20 subjects or 85%) compared to our male sample (25%) (Dickey et al, 1999) may account for the current finding of reduced hippocampi in SPD females while not in male SPD subjects. Additionally, small hippocampal volumes have been noted in several psychiatric disorders (Heckers, 2001), including major depression, (Caetano et al, 2004), with the total number of episodes correlating with reduced right hippcampal volumes (Videbech and Ravnkilde, 2004a) and the longer duration of untreated depression the smaller hippocampal volumes (Sheline et al, 2003). Given the high co-morbidity of depression in this female SPD sample, the hypothesis of major depression contributing to the small hippocampal volumes must be considered, but the small number of female SPD subjects without co-morbid disorders (N=3) prohibited a direct test of this hypothesis.…”

Section: Discussionmentioning

confidence: 99%

MRI abnormalities of the hippocampus and cavum septi pellucidi in females with schizotypal personality disorder

Dickey

McCarley

et al. 2007

Schizophrenia Research

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Objective-This study examined MRI hippocampal volume and cavum septi pellucidi (CSP) in female subjects with schizotypal personality disorder (SPD) and comparison subjects.Method-MRI was performed on 20 SPD and 29 comparison subjects with delineation of left and right hippocampi. Number of slices containing the CSP was counted. Subjects were given a working memory task, the Delayed Alternation task and other measures of working memory including the Wechsler Memory Test-Revised and the California Verbal Learning Test. Clinical measures were derived from the SCID-II.Results-SPD females evinced bilaterally smaller hippocampal volumes compared with nonpsychiatric female subjects (15.1% on left, 15.7% on right). Additionally, SPD subjects showed statistically significantly more slices containing CSP, and a trend level difference when large CSP was defined as four or more slices (20% vs. 6.9%). SPD subjects demonstrated more errors, more perseverations, and a trend toward more failure to maintain set on the Delayed Alternating task, which were associated with smaller left hippocampal volumes. There was no difference between groups in logical memory, verbal learning or semantic clustering nor a significant correlation between these measures and hippocampal volumes. Clinically, in SPD subjects, right hippocampal volumes correlated negatively with odd appearance/behavior and positively with suspiciousness/paranoia, and odd speech was positively correlated with the number of slices containing a CSP in exploratory analyses.Conclusions-Female SPD subjects showed bilaterally smaller hippocampal volumes and larger CSP than comparison subjects, similar to what has been shown in schizophrenia. Moreover, these abnormalities have clinically significant associations which may help to explain some of the manifestations of the disorder.

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“…However, inconsistent results had been reported in studies that had investigated the volume of the amygdala; in these studies, the volume of the amygdala was smaller in depressed subjects and larger in other studies compared to subjects with no depression. Moreover, no differences were found in the volume of the amygdala between the two groups in other studies [47][48][49][50][51][52][53][54]. According to the meta-analysis conducted by Hamilton et al [45], depression medications could increase and protect the amygdala by increasing its volume, whereas untreated depression may lead to a volume decrease of the amygdala.…”

Section: Sex Differences In Parkinson's Disease (Pd)mentioning

confidence: 92%

Structural Brain Sex Differences in Parkinson’s Disease: A Voxel-Based Morphometry Study

Alqarni¹

2017

J Neurol Disord

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Anatomical MRI study of hippocampus and amygdala in patients with current and remitted major depression

Cited by 177 publications

References 37 publications

Structural magnetic ressonance imaging in anxiety disorders: an update of research findings

Structural magnetic ressonance imaging in anxiety disorders: an update of research findings

MRI abnormalities of the hippocampus and cavum septi pellucidi in females with schizotypal personality disorder

Structural Brain Sex Differences in Parkinson’s Disease: A Voxel-Based Morphometry Study

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