Anatomical considerations for inhaled aerosol deposition modeling: Methods, applications, challenges and opportunities

Phalen, Robert F.; Hoover, Mark D.; Oldham, Michael J.; Schmid, Otmar; Golshahi, Laleh

doi:10.1016/j.jaerosci.2021.105786

Cited by 4 publications

(2 citation statements)

References 114 publications

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“…4 One major limitation to wider use of aerosol dosimetry models is the lack of species-specific or strain specific respiratory tract anatomy. Acquisition of the necessary respiratory tract anatomy has evolved from various manual digitization techniques [5][6][7] to non-invasive scanning methods (e.g., magnetic resonance imaging, computed tomography-CT. 8 Recently, micro-CT techniques were used to obtain the tracheobronchial tract anatomy of several mouse strains, [9][10][11][12] including those mouse strains used as in vivo models of human disease, such as chronic obstructive pulmonary disease (COPD; C57BL/6 mice), cardiovascular disease (CVD; ApoE-/-mice) and lung cancer (AJ mice). Numerous inhalation studies have used the C57BL/6 mouse as a model of COPD, [13][14][15][16][17][18] the ApoE-/-mouse (derived from the C57BL/ 6 mouse and is apolipoprotein E-deficient) as a model of CVD [19][20][21][22][23] and the AJ mouse as a model of lung cancer.…”

Section: Introductionmentioning

confidence: 99%

Predicted aerosol dosimetry for mouse models of chronic obstructive pulmonary disease, cardiovascular disease and lung cancer

Oldham,

Lucci,

Kuczaj

2023

Toxicology Research and Application

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Introduction For in vivo inhalation studies, aerosol dosimetry links aerosol exposure and deposited dose within the respiratory tract. Aerosol dosimetry programs like the Multiple Path Particle Deposition model utilize respiratory tract geometry, respiratory physiology, and aerosol properties to predict particle deposition within the respiratory tract. A challenge to wider use of these dosimetry programs for in vivo inhalation studies is the lack of species-specific or strain specific respiratory tract anatomy, and in some cases, strain specific respiratory physiology data. The objective of this work was to develop aerosol dosimetry predictions for the in vivo human disease models of chronic obstructive pulmonary disease (COPD; C57BL/6 mice) cardiovascular disease (CVD; ApoE-/- mice), and lung cancer (AJ mice) using the Multiple Path Particle Deposition dosimetry model. Methods Microcomputed tomography derived tracheobronchial geometry data were combined with available pulmonary geometry data for C57BL/6, ApoE-/-, and AJ mice and incorporated into the Multiple Path Particle Deposition dosimetry model. Mouse strain specific respiratory physiology literature values were used as input into the Multiple Path Particle Deposition dosimetry model. Results The resulting particle deposition predictions compared well with the very limited strain specific experimental particle deposition data. Since multiple tracheobronchial geometries and thus pulmonary anatomies were used for C57BL/6 and ApoE-/- mice, an estimate of intrastrain variability in predicted particle deposition was obtained. Discussion and Conclusions The intrastrain variability in predicted particle deposition for C57BL/6 and ApoE-/- mice was always smaller in the tracheobronchial compared to pulmonary airways. The differences in reported respiratory physiology values for C57BL/6 mice resulted in greater intrastrain variability in predicted particle deposition than observed with the different tracheobronchial geometries and pulmonary anatomies. These mouse strain specific aerosol dosimetry predictions can provide insight into the delivered dose to specific respiratory tract regions that can be correlated with in vivo endpoints.

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Section: Introductionmentioning

confidence: 99%

Predicted aerosol dosimetry for mouse models of chronic obstructive pulmonary disease, cardiovascular disease and lung cancer

Oldham,

Lucci,

Kuczaj

2023

Toxicology Research and Application

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“…Las partículas ultrafinas, hasta de varios nanómetros de diámetro, pueden llegar al torrente sanguíneo. No es descartable la migración de las partículas a otros órganos por diferentes vías (Manigrasso et al, 2020;Phalen et al, 2021).…”

Section: Introductionunclassified

Medio ambiente: Agricultura, desarrollo y sustentabilidad 3

Vieira,

Silva,

Oliveira

2023

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Editora Direitos para esta edição cedidos à Atena Editora pelos autores. Open access publication by Atena Editora Todo o conteúdo deste livro está licenciado sob uma Licença de Atribuição Creative Commons. Atribuição-Não-Comercial-NãoDerivativos 4.0 Internacional (CC BY-NC-ND 4.0). O conteúdo dos artigos e seus dados em sua forma, correção e confiabilidade são de responsabilidade exclusiva dos autores, inclusive não representam necessariamente a posição oficial da Atena Editora. Permitido o download da obra e o compartilhamento desde que sejam atribuídos créditos aos autores, mas sem a possibilidade de alterála de nenhuma forma ou utilizá-la para fins comerciais.Todos os manuscritos foram previamente submetidos à avaliação cega pelos pares, membros do Conselho Editorial desta Editora, tendo sido aprovados para a publicação com base em critérios de neutralidade e imparcialidade acadêmica.A Atena Editora é comprometida em garantir a integridade editorial em todas as etapas do processo de publicação, evitando plágio, dados ou resultados fraudulentos e impedindo que interesses financeiros comprometam os padrões éticos da publicação. Situações suspeitas de má conduta científica serão investigadas sob o mais alto padrão de rigor acadêmico e ético. Conselho Editorial Ciências Agrárias e Multidisciplinar

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Prediction of the transport, deposition, and absorption of multicomponent E-cigarette aerosols in a subject-specific mouth-to-G10 human respiratory system

Sperry

Feng

Zhao

et al. 2023

Journal of Aerosol Science

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Anatomical considerations for inhaled aerosol deposition modeling: Methods, applications, challenges and opportunities

Cited by 4 publications

References 114 publications

Predicted aerosol dosimetry for mouse models of chronic obstructive pulmonary disease, cardiovascular disease and lung cancer

Predicted aerosol dosimetry for mouse models of chronic obstructive pulmonary disease, cardiovascular disease and lung cancer

Medio ambiente: Agricultura, desarrollo y sustentabilidad 3

Prediction of the transport, deposition, and absorption of multicomponent E-cigarette aerosols in a subject-specific mouth-to-G10 human respiratory system

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