Prediction of the transport, deposition, and absorption of multicomponent E-cigarette aerosols in a subject-specific mouth-to-G10 human respiratory system

Nicotine flux and pharmacokinetics-based considerations for early assessment of nicotine delivery systems

“… pH of e-liquids The pH of e-liquids ranges between 4.78 and 9.60 ( Stepanov and Fujioka, 2015 ). pH influences the levels of unprotonated form and regional deposition by modulating the aerosol evolutionary processes such as gas-liquid partitioning of nicotine ( Pankow, 2001 , Sperry et al, 2023 ). The unprotonated form of nicotine is rapidly absorbed into systemic circulation and influences nicotine PK ( Benowitz, et al, 2009 ).…”