Anatomical Congruence of Metabolic and Electromagnetic Activation Signals during a Self-Paced Motor Task: A Combined PET–MEG Study

Joliot, Marc; Crivello, Fabrice; Badier, J.; Diallo, Barrou; Tzourio, N.; Mazoyer, Bernard

doi:10.1006/nimg.1998.0333

Cited by 27 publications

(10 citation statements)

References 53 publications

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“…Localization was not influenced by active tDCS (average deviation: 4.56 ±2.89 mm) (Fig. 5b), and results matched with findings in other neuroimaging studies 34,35 . Task-related signal source changes (for example, rolandic alpha desynchronization before or beta synchronization after button press) in the absence of and during DC stimulation (Fig.…”

Section: Resultssupporting

confidence: 89%

In vivo assessment of human brain oscillations during application of transcranial electric currents

et al. 2013

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Brain oscillations reflect pattern formation of cell assemblies’ activity, which is often disturbed in neurological and psychiatric diseases like depression, schizophrenia and stroke. In the neurobiological analysis and treatment of these conditions, transcranial electric currents applied to the brain proved beneficial. However, the direct effects of these currents on brain oscillations have remained an enigma because of the inability to record them simultaneously. Here we report a novel strategy that resolves this problem. We describe accurate reconstructed localization of dipolar sources and changes of brain oscillatory activity associated with motor actions in primary cortical brain regions undergoing transcranial electric stimulation. This new method allows for the first time direct measurement of the effects of non-invasive electrical brain stimulation on brain oscillatory activity and behavior.

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Section: Resultssupporting

confidence: 89%

In vivo assessment of human brain oscillations during application of transcranial electric currents

et al. 2013

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“…Multimodal studies performed by different groups showed similar findings of MEG and fMRI [Inoue et al, 1999;Morioka et al, 1995;Nimsky et al, 1999;Stippich et al, 1998], MEG and PET [Joliot et al, 1998], as well as MEG and intraoperative electrocorticography Roberts et al, 1995]. These findings underline the validity of the SEF and MEF localization results.…”

Section: Introductionsupporting

confidence: 71%

New approach to localize speech relevant brain areas and hemispheric dominance using spatially filtered magnetoencephalography

Kober

Möller

Nimsky

et al. 2001

Human Brain Mapping

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We used a current localization by spatial filtering-technique to determine primary language areas with magnetoencephalography (MEG) using a silent reading and a silent naming task. In all cases we could localize the sensory speech area (Wernicke) in the posterior part of the left superior temporal gyrus (Brodmann area 22) and the motor speech area (Broca) in the left inferior frontal gyrus (Brodmann area 44). Left hemispheric speech dominance was determined in all cases by a laterality index comparing the current source strength of the activated left side speech areas to their right side homologous. In 12 cases we found early Wernicke and later Broca activation corresponding to the Wernicke-Geschwind model. In three cases, however, we also found early Broca activation indicating that speech-related brain areas need not necessarily be activated sequentially but can also be activated simultaneously. Magnetoencephalography can be a potent tool for functional mapping of speech-related brain areas in individuals, investigating the time-course of brain activation, and identifying the speech dominant hemisphere. This may have implications for presurgical planning in epilepsy and brain tumor patients.

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“…Techniques with high spatial (fMRI) and high temporal (MEG) resolution have been advantageously combined before (Northoff, Richter, et al, 2000;Heinze et al, 1994), particularly in movements (Joliot et al, 1998;Stippich et al, 1998;Sanders, Lewine, & Orrison, 1996). Though there are several methodological problems applying two techniques with different neurophysiological substrates, blood oxygenic (fMRI) and electromagnetic (MEG) activity, the above-cited studies have nevertheless shown high coincidence between both kinds of signals (Northoff, Richter, et al, 2000;Joliot et al, 1998;Stippich et al, 1998;Sanders et al, 1996;Heinze et al, 1994). Consequently, combining spatial and temporal measures with fMRI and MEG may further reveal similarities and differences in physiological mechanisms in negative and positive emotional processing.…”

Section: Methodological Limitationsmentioning

confidence: 99%

GABA-ergic Modulation of Prefrontal Spatio-temporal Activation Pattern during Emotional Processing: A Combined fMRI/MEG Study with Placebo and Lorazepam

Northoff

Witzel

Richter

et al. 2002

Journal of Cognitive Neuroscience

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Various prefrontal cortical regions have been shown to be activated during emotional stimulation, whereas neurochemical mechanisms underlying emotional processing in the prefrontal cortex remain unclear. We therefore investigated the influence of the GABA-A potentiator lorazepam on prefrontal cortical emotional-motor spatio-temporal activation pattern in a combined functional magnetic resonance imaging/magnetoencephalography study. Lorazepam led to the reversal in orbito-frontal activation pattern, a shift of the early magnetic field dipole from the orbito-frontal to medial prefrontal cortex, and alterations in premotor/motor cortical function during negative and positive emotional stimulation. It is concluded that negative emotional processing in the orbito-frontal cortex may be modulated either directly or indirectly by GABA-A receptors. Such a modulation of orbito-frontal cortical emotional function by lorazepam has to be distinguished from its effects on cortical motor function as being independent from the kind of processing either emotional or nonemotional.

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Anatomical Congruence of Metabolic and Electromagnetic Activation Signals during a Self-Paced Motor Task: A Combined PET–MEG Study

Cited by 27 publications

References 53 publications

In vivo assessment of human brain oscillations during application of transcranial electric currents

In vivo assessment of human brain oscillations during application of transcranial electric currents

New approach to localize speech relevant brain areas and hemispheric dominance using spatially filtered magnetoencephalography

GABA-ergic Modulation of Prefrontal Spatio-temporal Activation Pattern during Emotional Processing: A Combined fMRI/MEG Study with Placebo and Lorazepam

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