Anatomical and molecular mapping of the left and right ventricular His–Purkinje conduction networks

Atkinson, Andrew; Inada, Shin; Li, Jue; Tellez, James O.; Yanni, Joseph; Sleiman, R.N.; Allah, Eman S.H. Abd; Anderson, Robert H.; Zhang, Henggui; Boyett, Mark R.; Dobrzynski, Halina

doi:10.1016/j.yjmcc.2011.05.020

Cited by 90 publications

(86 citation statements)

References 48 publications

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“…The left and right His branches emerge during the interventricular septation, when the trabecular myocytes penetrate inside the compact components of the septum [27] . With the thickening of the ventricle lateral and ventral walls, the trabecular myocytes develop an additional structure, the subendocardial Purkinje network [21,28] , which notably develops in response to an endothelial paracrine effect during the vascularization of the ventricles.…”

Section: Development Of the Human Cardiac Conduction Systemmentioning

confidence: 99%

Mechanisms underlying the cardiac pacemaker: the role of SK4 calcium-activated potassium channels

et al. 2016

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The proper expression and function of the cardiac pacemaker is a critical feature of heart physiology. The sinoatrial node (SAN) in human right atrium generates an electrical stimulation approximately 70 times per minute, which propagates from a conductive network to the myocardium leading to chamber contractions during the systoles. Although the SAN and other nodal conductive structures were identified more than a century ago, the mechanisms involved in the generation of cardiac automaticity remain highly debated. In this short review, we survey the current data related to the development of the human cardiac conduction system and the various mechanisms that have been proposed to underlie the pacemaker activity. We also present the human embryonic stem cellderived cardiomyocyte system, which is used as a model for studying the pacemaker. Finally, we describe our latest characterization of the previously unrecognized role of the SK4 Ca 2+ -activated K + channel conductance in pacemaker cells. By exquisitely balancing the inward currents during the diastolic depolarization, the SK4 channels appear to play a crucial role in human cardiac automaticity.

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Section: Development Of the Human Cardiac Conduction Systemmentioning

confidence: 99%

Mechanisms underlying the cardiac pacemaker: the role of SK4 calcium-activated potassium channels

et al. 2016

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“…Consecuentemente, los canales de calcio se encuentran en mayor proporción en los miocitos contráctiles. 25,27 Respecto a los túbulos transversos, se relacionan con escasas regiones del retículo sarcoplásmico, dado que no constituyen cisternas terminales, por lo que su conformación es de díadas y no tríadas descritas solamente en el músculo esquelético. Esta es una de las diferencias entre ambos tipos de tejido muscular estriado, siendo la función de la díada en la propagación de impulso eléctrico, similar a la de la tríada.…”

Section: Figura 3 Cardiomiocitos Conducentes Ventriculares En Imágenunclassified

Miocardiocitos conducentes ventriculares

2015

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ResumenObjetivo: Exponer las características histológicas y funcionales que se presentan en el tejido muscular estriado cardíaco especializado en la conducción del estímulo eléctrico y sus implicaciones actuales en las arritmias cardíacas. Materiales y métodos: Se seleccionaron publicaciones en revistas indexadas en las bases PubMed, Wiley, Ovid-Medline y Science Direct. Los descriptores MESH utilizados para la búsqueda fueron cardiac myocytes, myocardium, heart conduction system. Se acoplaron los conceptos histology y arrhythmia. Se revisaron artículos publicados entre 1990 a 2014, originales, reportes de caso y revisiones, relacionados con los conceptos de desarrollo embrionario, diferenciación celular, morfología normal y alteración de los miocardiocitos conducentes ventriculares. Se revisó el resumen de 317 artículos, de los que se clasificaron 75 para lectura completa y de estos, 52 se seleccionaron para la redacción del presente artículo. Conclusión: Los estudios actuales se encaminan hacia las simulaciones del sistema de conducción para establecer otras causas de arritmia y opciones de tratamiento. La terapia con células indiferenciadas y las técnicas moleculares de modificación genética hacen parte de estos estudios, así como la implementación de terapias alternativas no invasivas en el tratamiento de las arritmias cardíacas. AbstractObjective: To expose the histological and functional characteristics that occur in heart striated muscle tissue specialized in the conduction of electrical stimulation and its current implications for cardiac arrhythmias. Materials and methods: Publications in indexed journals in PubMed, Wiley, Ovid-Medline and Science Direct databases were selected. The MESH descriptors used for the search were cardiac myocytes, myocardium and heart conduction system. The concepts of histology and arrhythmia were mated. Articles published from 1990 to 2014 were reviewed as well as the original ones, case reports and reviews related to the concepts of embryonic development, cell differentiation and normal morphology alteration of the leading ventricular cardiomyocytes. The summary of 317 articles were read, from which 75 were classified to complete reading and finally 52 were selected for the drafting of this article. Conclusion: Current studies are directed towards the driving system simulation to establish other causes of arrhythmia and its treatment options. Not only therapies with undifferentiated cells and molecular genetic modification techniques are part of these studies but also the implementation of alternative therapies that are not invasive in the treatment of cardiac arrhythmias.

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“…The network has been segmented into different parts -shown in different colours. Red, left bundle branch (LBB); green, connecting Purkinje fibres; blue: terminal Purkinje fibres [1]. Figure 2.…”

Section: Introductionmentioning

confidence: 99%

Numerical Analysis of Conduction of the Action Potential Across the Purkinje Fibre:Ventricular Muscle Junction

Zhang

Boyett

2016

2016 Computing in Cardiology Conference (CinC)

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Anatomical and molecular mapping of the left and right ventricular His–Purkinje conduction networks

Cited by 90 publications

References 48 publications

Mechanisms underlying the cardiac pacemaker: the role of SK4 calcium-activated potassium channels

Mechanisms underlying the cardiac pacemaker: the role of SK4 calcium-activated potassium channels

Miocardiocitos conducentes ventriculares

Numerical Analysis of Conduction of the Action Potential Across the Purkinje Fibre:Ventricular Muscle Junction

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