Anatomic location and laterality of MRI signal hyperintensities in late-life depression

Tupler, Larry A.; Krishnan, K. Ranga; McDonald, William M.; Dombeck, Carrie B.; D'Souza, Sean; Steffens, David C.

doi:10.1016/s0022-3999(02)00425-7

Cited by 121 publications

(68 citation statements)

References 99 publications

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“…52 Many studies have shown that the WMH associations with LLD occur mainly in subcortical regions and their frontal white matter projections. 44,[53][54][55][56] Diffusion tensor imaging studies have also shown microstructural white matter abnormalities in fronto-striatal-limbic networks, including the lateral to anterior and posterior cingulate cortices and the prefrontal, insular and parahippocampal regions, are associated with executive dysfunction in patients with LLD. 46,57 A grey matter volume increase was observed in the right lingual gyrus both in the pooled meta-analysis and the subgroup meta-analysis.…”

Section: Discussionmentioning

confidence: 99%

Brain grey matter volume alterations in late-life depression

Liu

Chen

et al. 2014

jpn

120

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IntroductionLate-life depression (LLD) is a common and disabling disorder, which is typically defined as depression in individuals older than 60 years. Estimates of the prevalence of clinically relevant depressive symptoms in older adults typically range from 10% to 15%, and rates of major depression range from 1% to 5%.1-3 Late-life depression is characterized by diverse etiological factors that remain poorly understood.4,5 Successes in delineating the neurobiology of LLD have closely paralleled progress in neuroimaging and have provided evidence that LLD is associated with underlying brain anatomic and functional abnormalities. Structural neuroimaging findings have revealed grey matter volume reductions in multiple fronto-striatal-limbic regions of older depressed patients, including the anterior cingulate cortex (ACC), the prefrontal cortices, the striatum, the hippocampus and the amygdala, 4,6,7 and these regions are The aim of the present study was to conduct a meta-analysis that integrated the reported VBM studies, to determine consistent grey matter alterations in individuals with LLD. Methods: A systematic search was conducted to identify VBM studies that compared patients with LLD and healthy controls. We performed a meta-analysis using the effect size signed differential mapping method to quantitatively estimate regional grey matter abnormalities in patients with LLD. Results: We included 9 studies with 11 data sets comprising 292 patients with LLD and 278 healthy controls in our meta-analysis. The pooled and subgroup meta-analyses showed robust grey matter reductions in the right lentiform nucleus extending into the parahippocampus, the hippocampus and the amygdala, the bilateral medial frontal gyrus and the right subcallosal gyrus as well as a grey matter increase in the right lingual gyrus. Meta-regression analyses showed that mean age and the percentage of female patients with LLD were not significantly related to grey matter changes. Limitations: The analysis techniques, patient characteristics and clinical variables of the studies included were heterogeneous, and most participants were medicated. Conclusion: The present meta-analysis is, to our knowledge, the first to overcome previous inconsistencies in the VBM studies of LLD and provide robust evidence for grey matter alterations within fronto-striatal-limbic networks, thereby implicating them in the pathophysiology of LLD. The mean age and the percentage of female patients with LLD did not appear to have a measurable impact on grey matter changes, although we cannot rule out the contributory effects of medication.

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Section: Discussionmentioning

confidence: 99%

Brain grey matter volume alterations in late-life depression

Liu

Chen

et al. 2014

jpn

120

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“…White matter hyperintensities (WMH) are associated with executive dysfunction (Aizenstein et al 2002;Boone et al 1992;Lesser et al 1996), are more prevalent and severe in depressed older individuals than age-matched controls, and mainly occur in subcortical regions and their frontal white matter projections (Coffey et al 1990;Greenwald et al 1998;Krishnan 1993, Krishnan et al 1997Lenze et al 1999;O'Brien et al 1996;Taylor et al 2003aTaylor et al , 2005Tupler et al 2002). Gray matter volume reductions are present in multiple frontostriatal-limbic regions of older depressives, including the anterior cingulate, prefrontal cortices, the neostriatum, the hippocampus, and the amygdala (Ballmaier et al 2004;Krishnan et al 1992;Kumar et al 2000;Lai et al 2000;Steffens et al 2002;Taylor et al 2003b).…”

Section: Introductionmentioning

confidence: 99%

White-Matter Integrity Predicts Stroop Performance in Patients with Geriatric Depression

Murphy¹,

Gunning-Dixon²,

Hoptman³

et al. 2007

Biological Psychiatry

111

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“…Numerous other reports have also found greater total WML volumes in elderly depressed subjects (Krishnan et al, 1988;Dolan et al, 1990;Fujikawa et al, 1993;Krishnan, 1993;Greenwald et al, 1996;Steffens et al, 1999;Kumar et al, 2000;Tupler et al, 2002), but few of these studies examined the location of WMLs. Using an objective method of quantifying WML volume within each lobe, we have confirmed reports (Greenwald et al, 1998;MacFall et al, 2001;Taylor et al, 2003b;Firbank et al, 2004) that the preponderance of WMLs that are different between depressed and control populations occur in the frontal lobe.…”

Section: Discussionmentioning

confidence: 97%

“…Many reports associate hyperintense lesions with late-life depression. White and gray matter hyperintense lesions are more severe in older depressed subjects than nondepressed subjects (Krishnan et al, 1988;Dolan et al, 1990;Fujikawa et al, 1993;Krishnan, 1993;Greenwald et al, 1996;Steffens et al, 1999;Kumar et al, 2000;Tupler et al, 2002;Taylor et al, 2005), and are more severe in late-onset than early-onset elderly depressed subjects (Figiel et al, 1991;Hickie et al, 1995;Salloway et al, 1996;Krishnan et al, 1997;Lavretsky et al, 1998;de Groot et al, 2000;Tupler et al, 2002). Increases in WML severity over time are additionally associated with new onset of depression (Lavretsky et al, 1999;Nebes et al, 2002) and poorer outcomes to antidepressant therapy (Simpson et al, 1997;O'Brien et al, 1998;Taylor et al, 2003c), although some have not found a relationship between WML severity and treatment outcomes (Salloway et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

Lobar Distribution of Lesion Volumes in Late-Life Depression: The Biomedical Informatics Research Network (BIRN)

MacFall

Taylor

Rex

et al. 2005

Neuropsychopharmacol

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White matter hyperintense lesions on T2-weighted images are associated with late-life depression. Little work has been carried out examining differences in lesion location between elderly individuals with and without depression. In contrast to previous studies examining total brain white matter lesion volume, this study examined lobar differences in white matter lesion volumes derived from brain magnetic resonance imaging. This study examined 49 subjects with a DSM-IV diagnosis of major depression and 50 comparison subjects without depression. All participants were age 60 years or older. White matter lesion volumes were measured in each hemisphere using a semiautomated segmentation process and localized to lobar regions using a lobar atlas created for this sample using the imaging tools provided by the Biomedical Informatics Research Network (BIRN). The lobar lesion volumes were compared against depression status. After controlling for age and hypertension, subjects with depression exhibited significantly greater total white matter lesion volume in both hemispheres and in both frontal lobes than did control subjects. Although a similar trend was observed in the parietal lobes, the difference did not reach a level of statistical significance. Models of the temporal and occipital lobes were not statistically significant. Older individuals with depression have greater white matter disease than healthy controls, predominantly in the frontal lobes. These changes are thought to disrupt neural circuits involved in mood regulation, thus increasing the risk of developing depression.

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Anatomic location and laterality of MRI signal hyperintensities in late-life depression

Cited by 121 publications

References 99 publications

Brain grey matter volume alterations in late-life depression

Brain grey matter volume alterations in late-life depression

White-Matter Integrity Predicts Stroop Performance in Patients with Geriatric Depression

Lobar Distribution of Lesion Volumes in Late-Life Depression: The Biomedical Informatics Research Network (BIRN)

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