White-Matter Integrity Predicts Stroop Performance in Patients with Geriatric Depression

Murphy, Christina; Gunning-Dixon, Faith M.; Hoptman, Matthew J.; Lim, Kelvin O.; Ardekani, Babak A.; Shields, Jessica; Hrabě, Jan; Kanellopoulos, Dora; Shanmugham, Bindu; Alexopoulos, George S.

doi:10.1016/j.biopsych.2006.07.028

Cited by 113 publications

(115 citation statements)

References 51 publications

(43 reference statements)

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“…44,[53][54][55][56] Diffusion tensor imaging studies have also shown microstructural white matter abnormalities in fronto-striatal-limbic networks, including the lateral to anterior and posterior cingulate cortices and the prefrontal, insular and parahippocampal regions, are associated with executive dysfunction in patients with LLD. 46,57 A grey matter volume increase was observed in the right lingual gyrus both in the pooled meta-analysis and the subgroup meta-analysis. This brain region is not typically implicated in mood disorders.…”

Section: Discussionmentioning

confidence: 94%

“…Our findings are in line with those of a postmortem study of patients with major depressive disorder that reported decreases in the density or number of glia and the density and size of neurons in the ACC 43 in patients with LLD. Functional neuroimaging studies have also reported decreased spontaneous neural activity in the right ACC and the bilateral medial prefrontal gyrus [44][45][46] in patients with LLD relative to controls. It is striking that the subcallosal gyrus, which was identified in this meta-analysis, is an important target for deep brain stimulation treatment for treatment-resistant depression, with good long-term safety and antidepressant efficacy.…”

Section: Discussionmentioning

confidence: 99%

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Brain grey matter volume alterations in late-life depression

Liu

Chen

et al. 2014

jpn

124

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IntroductionLate-life depression (LLD) is a common and disabling disorder, which is typically defined as depression in individuals older than 60 years. Estimates of the prevalence of clinically relevant depressive symptoms in older adults typically range from 10% to 15%, and rates of major depression range from 1% to 5%.1-3 Late-life depression is characterized by diverse etiological factors that remain poorly understood.4,5 Successes in delineating the neurobiology of LLD have closely paralleled progress in neuroimaging and have provided evidence that LLD is associated with underlying brain anatomic and functional abnormalities. Structural neuroimaging findings have revealed grey matter volume reductions in multiple fronto-striatal-limbic regions of older depressed patients, including the anterior cingulate cortex (ACC), the prefrontal cortices, the striatum, the hippocampus and the amygdala, 4,6,7 and these regions are The aim of the present study was to conduct a meta-analysis that integrated the reported VBM studies, to determine consistent grey matter alterations in individuals with LLD. Methods: A systematic search was conducted to identify VBM studies that compared patients with LLD and healthy controls. We performed a meta-analysis using the effect size signed differential mapping method to quantitatively estimate regional grey matter abnormalities in patients with LLD. Results: We included 9 studies with 11 data sets comprising 292 patients with LLD and 278 healthy controls in our meta-analysis. The pooled and subgroup meta-analyses showed robust grey matter reductions in the right lentiform nucleus extending into the parahippocampus, the hippocampus and the amygdala, the bilateral medial frontal gyrus and the right subcallosal gyrus as well as a grey matter increase in the right lingual gyrus. Meta-regression analyses showed that mean age and the percentage of female patients with LLD were not significantly related to grey matter changes. Limitations: The analysis techniques, patient characteristics and clinical variables of the studies included were heterogeneous, and most participants were medicated. Conclusion: The present meta-analysis is, to our knowledge, the first to overcome previous inconsistencies in the VBM studies of LLD and provide robust evidence for grey matter alterations within fronto-striatal-limbic networks, thereby implicating them in the pathophysiology of LLD. The mean age and the percentage of female patients with LLD did not appear to have a measurable impact on grey matter changes, although we cannot rule out the contributory effects of medication.

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Brain grey matter volume alterations in late-life depression

Liu

Chen

et al. 2014

jpn

124

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“…16 Region of interest (ROI)-based DTI studies in patients with late-life depression have consistently reported reduced fractional anisotropy values in prefrontal brain regions. [17][18][19][20][21][22] Reduced fractional anisotropy in the cingulate cortex has also been detected. 19,23,24 In addition, Yang and colleagues 22 and Murphy and colleagues 19 reported a reduction in fractional anisotropy values in the parahippocampal gyrus.…”

Section: Introductionmentioning

confidence: 90%

“…[17][18][19][20][21][22] Reduced fractional anisotropy in the cingulate cortex has also been detected. 19,23,24 In addition, Yang and colleagues 22 and Murphy and colleagues 19 reported a reduction in fractional anisotropy values in the parahippocampal gyrus. On the other hand, Lu and colleagues 25 detected an increase in fractional anisotropy values in areas of the brain associated with mood regulation, such as the right superior frontal gyrus to right pallidum and left superior parietal gyrus to right super ior occipital gyrus, by performing tractography analysis in patients with MDD.…”

Section: Introductionmentioning

confidence: 90%

Effects of early-life adversity on white matter diffusivity changes in patients at risk for major depression

Frodl

Carballedo

Fagan

et al. 2012

jpn

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“…Behavioral studies showing abnormally high interference effects in Stroop paradigms by patients with HIV-alcoholism comorbidity (Schulte et al 2005) or late-life depression (Murphy et al 2006) provide inferential evidence for degraded integrity of the intrahemispheric frontoparietal attention network. Our current findings extend this functional network to include interhemispheric effects of HIV-alcoholism comorbidity on Stroop interference effects.…”

Section: Discussionmentioning

confidence: 99%

Callosal Compromise Differentially Affects Conflict Processing and Attentional Allocation in Alcoholism, HIV, and Their Comorbidity

Schulte

Müller‐Oehring

Javitz

et al. 2007

Brain Imaging and Behavior

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Diffusion tensor imaging was used to study the combined effects of HIV-infection and alcoholism (ALC) on corpus callosum (CC) integrity in relation to processes of attentional allocation and conflict resolution assessed by a novel Stroop Match-to-Sample task. We tested 16 ALC, 19 HIV, 20 subjects with combined disorder and 17 controls. In ALC, low fractional anisotropy and high mean diffusivity throughout the CC correlated with poor Stroop-match performance, i.e., when the cue-color matched the color of the Stroop stimulus. By contrast, in the two HIV groups DTI relations were restricted to the genu and poor Stroop-nonmatch performance, i.e., when the cue-color was in conflict with the Stroop stimulus color. These results suggest that disruption of callosal integrity in HIV-infection and alcoholism differentially affects regionally-selective interhemispheric-dependent attentional processing. We speculate that callosal degradation in these diseases curtails the opportunity for collaboration between the two hemispheres that contributes to normal performance in HIV or alcoholic patients with higher callosal integrity. KeywordsDiffusion tensor imaging; HIV infection; Alcoholism; Stroop; Selective attention; Corpus callosum A frequent comorbidity in individuals infected with human immunodeficiency virus (HIV) is alcohol use disorder (Justice et al. 2006;Lefevre et al. 1995;Meyerhoff 2001;Molina et al. 2006;Winsauer et al. 2002). Each disorder exerts adversive effects on cognitive function and brain structure, some different and some overlapping. Although both disorders affect attention, each can selectively disrupt different component processes of this NIH Public Access Author ManuscriptBrain Imaging Behav. Author manuscript; available in PMC 2009 April 8. Published in final edited form as:Brain Imaging Behav. 2008 ; 2(1): 27-38. doi:10.1007/s11682-007-9014-z. NIH-PA Author ManuscriptNIH-PA Author Manuscript NIH-PA Author Manuscript complex cognitive process. Chronic alcoholism adversely disrupts executive control mechanisms relying on prefrontal and parietal attentional brain systems (Nixon et al. 1988;Sullivan et al. 2000;Tapert et al. 2001). Lack of executive function control over attentional systems has also been reported in patients infected with human immunodeficiency virus (HIV) (Chao et al. 2004;Hinkin et al. 1999;McArthur 2004;Sahakian et al. 1995).The Stroop Color Word Test (Stroop 1935) is a widely used paradigm to study selective attentional processes that require conflict resolution and response inhibition between competing stimulus attributes (Bush et al. 2003;Carter et al. 1999;Fan et al. 2003;MacDonald et al. 2000;Salo et al. 2001). The Stroop phenomenon describes slower responses when subjects are asked to name the ink color of a word printed in a color incongruent with the word's meaning (e.g., the word "red" written in blue ink) relative to when the word's meaning and ink color are the same (e.g., the word "red" written in red ink). When the relevant color-attribute and the irrelevant word-...

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White-Matter Integrity Predicts Stroop Performance in Patients with Geriatric Depression

Abstract: Background-This study tested the hypothesis that microstructural white matter abnormalities in frontostriatal-limbic tracts are associated with poor response inhibition on the Stroop task in depressed elders.

Cited by 113 publications

References 51 publications

Brain grey matter volume alterations in late-life depression

Brain grey matter volume alterations in late-life depression

Effects of early-life adversity on white matter diffusivity changes in patients at risk for major depression

Callosal Compromise Differentially Affects Conflict Processing and Attentional Allocation in Alcoholism, HIV, and Their Comorbidity

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