Anatomic identification and functional outcomes of the nerve sparing Okabayashi radical hysterectomy

Fujii, Shingo; Takakura, Kenji; Matsumura, Noriomi; Higuchi, Toshihiro; Yura, Shigeo; Mandai, Masaki; Baba, Tsukasa; Yoshioka, Shinya

doi:10.1016/j.ygyno.2007.08.076

Cited by 166 publications

(123 citation statements)

References 13 publications

Supporting

Mentioning

114

Contrasting

Unclassified

Order By: Relevance

“…However, the first surgical priority in patients with cervical cancer should be minimizing the possibility of failure to remove isolated paracervical neoplastic foci. Therefore, nerve-sparing radical hysterectomy [5,33] seems to offer the most effective balance between oncological safety and surgery-related complications, and would be particularly useful in selected patients such as those with early-stage disease but a high risk of paracervical involvement. Robotic lymphadenectomy including skeletonisation of the artery and vein has been tried at several hospitals for gastric cancer Figure 1B (an 80-year-old woman), displays lymphatic vessels (arrows) along a vein draining to the external surface of the bladder; B.…”

Section: Discussionmentioning

confidence: 99%

“…Using cross-sectional histology with D2-40 immunohistochemistry, we took photos at hot spots of LVs [32] in each of the sections to allow compari- Mean ± standard deviation (% in 6 mm 2 including accumulation of lymphatic vessels); 1 Along and around the uterine artery and its branches; 2 Along and around the superior vesical arteries and veins; 3 In the subperitoneal tissue in the broad ligament of the uterus; 4 In the paracolpium or paravaginal tissue 3-4 cm below the uterine cervix; 5 In smooth muscles of the bladder or ureter.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Lymphatic vessels around the uterus: D2-40 (podoplandin) immunohistochemistry using elderly cadavers

Sasaki

Jin

Liu³

et al. 2016

Folia Morphol

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Lymphatic vessels around the uterus: D2-40 (podoplandin) immunohistochemistry using elderly cadavers

Sasaki

Jin

Liu³

et al. 2016

Folia Morphol

View full text Add to dashboard Cite

show abstract

“…Based on mathematical models of the decline of the antibody over the years, boosters may not be needed for at least 20 years. Since registration data was based on efficacy trials in [16][17][18][19][20][21][22][23][24][25][26] years of age and bridging immunological response study of adolescence, efficacy on adult women was performed for data in supporting registration up to 45 years of age. 12,16 The quadrivalent vaccine trial in 24-45 year old women showed 83% efficacy in preventing persistent infection, CIN or external genital lesion (EGL).…”

Section: Update On Hpv Vaccination Hextan Y S Nganmentioning

confidence: 99%

“…Other recent advances in the surgical management of early stage cervical cancer include nerve-sparing radical hysterectomy and fertility-sparing radical trachelectomy. 22 The major merit of these operations is to improve the functional outcome and quality of life.…”

Section: Radical Surgery Overview Jong Hyeok Kim/joo-hyun Nammentioning

confidence: 99%

See 1 more Smart Citation

Asian society of gynecologic oncology workshop 2010

et al. 2010

View full text Add to dashboard Cite

and was organized to promote the academic environment and to enhance the communication among Asian countries prior to the 2nd biennial meeting of Australian Society of Gynaecologic Oncologists (ASGO), which will be held on November 3-5, 2011. We summarized the whole contents presented at the workshop. Regarding cervical cancer screening in Asia, particularly in low resource settings, and an update on human papillomavirus (HPV) vaccination was described for prevention and radical surgery overview, fertility sparing and less radical surgery, nerve sparing radical surgery and primary chemoradiotherapy in locally advanced cervical cancer, were discussed for management. As to surgical techniques, nerve sparing radical hysterectomy, optimal staging in early ovarian cancer, laparoscopic radical hysterectomy, one-port surgery and robotic surgery were introduced. After three topics of endometrial cancer, laparoscopic surgery versus open surgery, role of lymphadenectomy and fertility sparing treatment, there was a special additional time for clinical trials in Asia. Finally, chemotherapy including neo-adjuvant chemotherapy, optimal surgical management, and the basis of targeted therapy in ovarian cancer were presented.

show abstract

Oncological Outcomes After Okabayashi-Kobayashi Radical Hysterectomy for Early and Locally Advanced Cervical Cancer

Sakuragi

Kato

Shimada³

et al. 2020

JAMA Netw Open

View full text Add to dashboard Cite

IMPORTANCEThe role of surgery in early-stage cervical cancer has been established, but it is controversial in locally advanced cervical cancer.OBJECTIVE To determine whether a radical hysterectomy method with extended removal of paracervical tissue for locally advanced cervical cancer is associated with satisfactory oncological outcomes. DESIGN, SETTING, AND PARTICIPANTS This retrospective cohort study was conducted fromJanuary 1, 2002, to December 31, 2011, and participants were patients with cervical cancer at a single tertiary center in Northern Japan. The median follow-up period was 106 months, and none of the patients were lost to follow-up at less than 60 months. Data analyses were performed from July 1, 2017, to December 31, 2018.EXPOSURES Patients underwent radical hysterectomy using the Okabayashi-Kobayashi method.Bilateral nerve preservation was used for stage IB1/IB2 disease and unilateral nerve preservation for stage IIA/IIB if disease extension outside the uterine cervix was 1-sided. Chemotherapy was used as the choice of adjuvant treatment for patients with an intermediate or high risk of recurrence, while some patients chose or were assigned to radiotherapy. MAIN OUTCOMES AND MEASURESPrimary outcomes were the 5-year local control rate and 5-year overall survival rate along with risk factor analysis. RESULTS Of 121 consecutive patients, 76 (62.8%) had early-stage cervical cancer in 2008 International Federation of Gynecology and Obstetrics stages IB1 and IIA1 and 45 (37.2%) had locally advanced cervical cancer in stages IB2, IIA2, and IIB. The median (range) age was 42 (26-68) years.Adjuvant radiotherapy was used in 2 patients (3%) with early-stage cervical cancer and 3 (7%) of those with locally advanced cervical cancer. The 5-year local control rates for early-stage cervical cancer and locally advanced cervical cancer were 99% and 87%, respectively. The 5-year overall survival rates for early-stage cervical cancer and locally advanced cervical cancer were 95% and 82%, respectively. Cox regression analysis showed that lymph node metastasis and histology of adeno(squamous)carcinoma were independent risk factors for the overall survival of patients with cervical cancer treated with radical hysterectomy. CONCLUSIONS AND RELEVANCEThe nerve-sparing Okabayashi-Kobayashi radical hysterectomy for locally advanced cervical cancer may provide survival not inferior to radical hysterectomy or radiotherapy in published literature. The applicability of radical hysterectomy with adjuvant (continued) Key Points Question Is radical hysterectomy with extended removal of paracervical tissue associated with satisfactory outcomes for locally advanced cervical cancer? Findings This retrospective cohort study of 121 patients with cervical cancer treated with Okabayashi-Kobayashi radical hysterectomy showed that the 5-year local control rates for early-stage IB1/IIA1 disease and locally advanced stage IB2/IIA2/IIB disease were 99% and 87%, respectively, and the 5-year overall survival rates for these groups were 95% and 8...

show abstract

Anatomic identification and functional outcomes of the nerve sparing Okabayashi radical hysterectomy

Cited by 166 publications

References 13 publications

Lymphatic vessels around the uterus: D2-40 (podoplandin) immunohistochemistry using elderly cadavers

Lymphatic vessels around the uterus: D2-40 (podoplandin) immunohistochemistry using elderly cadavers

Asian society of gynecologic oncology workshop 2010

Oncological Outcomes After Okabayashi-Kobayashi Radical Hysterectomy for Early and Locally Advanced Cervical Cancer

Contact Info

Product

Resources

About