Anaplastic Thyroid Carcinoma: A 25-year Single-Institution Experience

Abstract

In patients with locoregional limited disease, multimodality treatment with gross total surgical resection and postoperative radiotherapy with or without chemotherapy offers the best local control and DSS.

Anaplastic thyroid carcinoma: review of treatment protocols

“…Several retrospective studies have demonstrated significant survival benefit for ATC patients treated with a multimodal approach (Haymart et al 2013, Mohebati et al 2014, Wendler et al 2016. In an analysis of the Memorial Sloan Kettering Cancer Center, New York, 95 ATC patients treated between 1985 and 2010 were included.…”

“…In an analysis of the Memorial Sloan Kettering Cancer Center, New York, 95 ATC patients treated between 1985 and 2010 were included. Patients who had surgery, radiotherapy and/or chemotherapy had 42% 1-year disease-specific survival (DSS) compared to patients without surgery or surgery alone, showing only 6% 1-year DSS (Mohebati et al 2014). In contrast, an analysis of 2742 ATC patients diagnosed between 1998 and 2008 (US National Cancer Database) showed only marginal treatment benefit: median survival rates in patients receiving multimodal treatment ranged between 11.2 months in stage IVA patients, 9.9 months in stage IVB patients and 4.9 months in stage IVC patients (Haymart et al 2013).…”

Anaplastic thyroid cancer

“…Intensity-Modulated Radiation Therapy has shown better results with reduced toxicity [6]. Chemoradiation has been shown to be superior to radiation alone [7,8]. The recommended chemotherapeutic agents are doxorubicine alone or a combination of drugs in patients with good performance status who desire aggressive therapy.…”

“…A recent retrospective review of 95 patients at a tertiary cancer center highlights the prognostic factors and outcomes associated with ATC [8]. More than 65% of the patients were over the age of 65 years, with 50% of patients having concurrent or previous history of differentiated thyroid cancer.…”

Patterns of Failure in Anaplastic and Differentiated Thyroid Carcinoma Treated with Intensity-Modulated Radiotherapy

“…These undifferentiated tumours are extremely aggressive, recurring both locally and distantly. Radiotherapy decreases local recurrence, reduces the morbidity associated with atc progression, and might increase cancer-specific survival [1][2][3][4][5] .…”