Anaplastic Ependymoma in the Cervical Spinal Cord of a Maltese Dog

Michimae, Yoshiko; Morita, Takehito; Sunagawa, Yuki; Sawada, Masumi; Okamoto, Yoshiharu; Shimada, Akinori

doi:10.1292/jvms.66.1155

Cited by 16 publications

(29 citation statements)

References 11 publications

(13 reference statements)

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“…For human beings, this neoplasm commonly develops in the spinal cord and the fourth ventricle (Koestner and Higgins, 2002;Michimae et al, 2004;Vural et al, 2006); however, in the case of animals, the tumor mainly develops within the lateral ventricles, less often in third or fourth ventricle and rarely in the central canal of spinal cord (Koestner and Higgins, 2002). Regarding the pediatric cases, the location is usually intracranial; however, it is spinal for adults.…”

Section: Olgu Sunumumentioning

confidence: 99%

“…Among domestic animals, ependymomas are relatively rare tumors reported in a few cases including dogs, cats, cattle, horses, and rats (Carrigan et al, 1996;McGill and Wells, 1993;McKay et al, 1999;Michimae et al, 2004;Simpson et al, 1999;Vural et al, 2006). Ependymomas are occasionally reported in human infants; however, they are rarely observed in animals.…”

Section: Introductionmentioning

confidence: 99%

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Histopathological and immunohistochemical characteristics of ventricular ependymoma in a goat

Farjanikish¹,

Khodakaram-Tafti²

2016

İstanbul Üniversitesi Veteriner Fakültesi Dergisi

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Ependymomas as primary central nervous system neoplasms are occasionally observed in human infants however; they are rare in animals. A three-year-old male goat was presented with clinical neurological signs. At necropsy, a 3×2×2 cm, bulging, white-grey-to red, soft mass extending into the left lateral ventricle of brain was observed. Microscopically, the mass with densely cellular population was nonencapsulated, mostly containing cuboidal-columnar neoplastic cells with pseudo-rosettes formation. Mitotic figures were rare and malignancy indexes were not observed. Neoplastic cells were immunohistochemically positive for Glial Fibrillary Acidic Protein (GFAP), S-100, and vimentin; however, they did not express Cytokeratins. On the basis of the location, histologic and immunohistochemical findings, the tumor was diagnosed as an ependymoma.

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Section: Olgu Sunumumentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Histopathological and immunohistochemical characteristics of ventricular ependymoma in a goat

Farjanikish¹,

Khodakaram-Tafti²

2016

İstanbul Üniversitesi Veteriner Fakültesi Dergisi

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“…They arise from ependymal cells lining the ventricles and the spinal cord central canal (Summers and others 1995, Koestner and Higgins 2002). Ependymomas are more often intracranial (Savage and others 1962, Turrel and others 1986, Kraft and others 1997, Vural and others 2006) than intramedullary (Chaffee 1977, Zachary and others 1981, Michimae and others 2004, Ueno and others 2006). In dogs, only three cases have been reported as anaplastic (malignant) ependymoma of the central nervous system, two of which were located in the spine (Teusher and Cherrstrom 1974, Michimae and others 2004) and one in the fourth ventricle (Savage and others 1962).…”

Section: Introductionmentioning

confidence: 99%

Cachexia secondary to intracranial anaplastic (malignant) ependymoma in a boxer dog

Borrelli¹,

Mattiazzi²,

Capucchio

et al. 2009

J of Small Animal Practice

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An eight-year-old female boxer was referred because of weight loss of several months' duration. On physical examination, cachexia was the only reported abnormality. Neurological symptoms were shown only in the last days preceding death and consisted of altered mental status, compulsive behaviour and left rear proprioception deficit. At post-mortem examination, a voluminous, soft, haemorrhagic mass was found invading the floor of the brain. Based on the morphological features of the tumour, marked parenchymal invasion, extensive necrosis and cellular atypia, the mass was classified as an anaplastic ependymoma. This case report shows similarities to the diencephalic syndrome reported in human paediatric medicine in which the main clinical sign is a profound emaciation in spite of normal or slightly diminished caloric intake. Weight loss and cachexia are clinically relevant problems in small animals and these clinical signs should raise a suspicion, among the other differentials, of a brain tumour, even in absence of neurologic signs.

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“…; Teuscher and Cherrstrom ; Michimae et al . ). In man, histological subclassification includes cellular, papillary, myxopapillary, subependymoma, tanycytic and clear cell variants (Friede and Pollak ).…”

Section: Introductionmentioning

confidence: 97%

Cerebral malacia in a mule with ependymoma

Córdova

Burns

Ramos

et al. 2014

Equine Veterinary Education

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Ependymoma is a rare tumour of the central nervous system that can vary in anatomical location and produce a broad range of clinical signs. Sporadically described in dogs, cats, cattle and horses, this disease has never previously been reported in a mule. This report describes a case of a 12-year-old mule showing neurological signs, including blindness, dysphagia, incoordination, sternal recumbency, depression, apathy and emaciation. Because of the worsening health conditions, the animal was subjected to euthanasia for humane reasons. At necropsy, an area of malacia in the right subcortical region of the frontoparietal area of the cerebrum and an ovoid, firm, grey, 2.4 × 1.0 × 0.7 cm nodule in the right lateral ventricle was observed. Histopathology revealed that the nodule was a densely cellular mass with cells arranged in nests and cords, formations of pseudorosettes with perivascular deposition of fibrillar eosinophilic material and the presence of a few lymphocytes. The cells had rounded and moderately hyperchromatic nuclei, punctate chromatin, distinct nucleoli, and indistinct cytoplasmic margins. Based on the histopathological features, the nodule was diagnosed as an ependymoma, a tumour considered rare, but that may be included in the differential diagnosis for diseases with neurological signs.

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Anaplastic Ependymoma in the Cervical Spinal Cord of a Maltese Dog

Cited by 16 publications

References 11 publications

Histopathological and immunohistochemical characteristics of ventricular ependymoma in a goat

Histopathological and immunohistochemical characteristics of ventricular ependymoma in a goat

Cachexia secondary to intracranial anaplastic (malignant) ependymoma in a boxer dog

Cerebral malacia in a mule with ependymoma

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