1985
DOI: 10.1590/s0036-46651985000400004
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Anaphylaxis with Schistosoma mansoni extracts in normal and infected mice

Abstract: Methods generally utilized for studies on anaphylaxis to protein antigens such as determination of histamine release to the blood, hemoconcentration, histamine release from peritoneal mast cells and passive cutaneous anaphylaxis (PCA) were used to investigate some aspects of the anaphylaxis to parasite antigens in Schistosoma mansoni infected mice. The release of histamine to the blood and significant rates of hemoconcentration were induced by intravenous injection of schistosomula or cercarial extracts into 1… Show more

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Cited by 5 publications
(3 citation statements)
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References 14 publications
(7 reference statements)
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“…This defence mechanism is extremely important in S. stercoralis infection because persistence of parasite infection and development of disseminated strongyloidiasis is dependent on autoinfection that occurs after the transformation of rhabditiform larvae into the infective filariform larvae in the intestinal lumen. In experimental models, killing of S. mansoni may occur after mast cell degranulation (36), and in vitro , eosinophils can kill parasites by the mechanisms of antibody‐dependent cellular cytotoxicity (37). In humans, resistance to re‐infection with S. mansoni is an age‐dependent phenomenon also related to anti‐schistosomal IgE antibody or the anti‐schistosomal IgE/IgG ratio (38).…”
Section: Immunological Responses and Helminth Infectionmentioning
confidence: 99%
“…This defence mechanism is extremely important in S. stercoralis infection because persistence of parasite infection and development of disseminated strongyloidiasis is dependent on autoinfection that occurs after the transformation of rhabditiform larvae into the infective filariform larvae in the intestinal lumen. In experimental models, killing of S. mansoni may occur after mast cell degranulation (36), and in vitro , eosinophils can kill parasites by the mechanisms of antibody‐dependent cellular cytotoxicity (37). In humans, resistance to re‐infection with S. mansoni is an age‐dependent phenomenon also related to anti‐schistosomal IgE antibody or the anti‐schistosomal IgE/IgG ratio (38).…”
Section: Immunological Responses and Helminth Infectionmentioning
confidence: 99%
“…In contrast, the number of degranulating mast cells increased at the first day of re-infection as expected for IgE bearing mice (Mota-Santos et al 1985). In the skin of re-infected mice, the reaction also involves early mast cell degranulation (Bentley et al 1981, Incani & McLaren 1984.…”
Section: Discussionmentioning
confidence: 60%
“…A reação de anafilaxia cutânea passiva (ACP), segundo Mota e Wong (1985) [95] , foi utilizada na detecção de anticorpos da classe IgE. Ratos previamente depilados no dorso foram injetados intradermicamente com 100 L de diluições seriadas de amostras de soro obtidas de camundongos imunes.…”
Section: Reação De Anafilaxia Cutânea Passiva (Acp)unclassified