Anaphylaxis to penicillins after non‐therapeutic exposure: an immunological investigation

Abstract

these results show that non-therapeutic exposure to penicillin can cause severe symptoms and that in vitro and in vivo testing can help in the diagnosis of such cases.

IgE-mediated allergy to chlorhexidine

“…A recent study of IgE to chlorhexidine measured by a prototype of the ImmunoCAP in patients with positive prick test results to chlorhexidine digluconate had a lower yield of positive IgE tests, but sera were taken an average of 29 months after the reaction. 14 A decline in the IgE antibody response to chlorhexidine has previously been measured in 1 patient, 8 and the same has been described for other allergens such as penicillin 15 and insect venom. 16 In this study, serial analyses for both IgE and HR in 1 patient showed an almost identical decline over time (Fig 5, A).…”

Decrease of selective immunoglobulin E response to amoxicillin despite repeated administration of benzylpenicillin and penicillin V

“…Little evidence is available in the literature concerning this problem. Resensitization studies indicate that negative patients may become positive, not only after therapeutic administration [15,16,20] but also after non-therapeutic exposure to betalactams [21].…”

Drug-Induced Anaphylaxis

“…The availability of diagnostic tests and determination of specific IgE antibodies has made it possible to study this model in great detail [1]. Clinical experience with such patients indicates that reactions can be induced by very low concentrations of drugs through the oral route, skin testing or inadvertent exposures [43][44][45]. If a subject takes amoxicillin or another BL derivative and develops an anaphylactic response after an interval of over 1 h, we are likely dealing with an accelerated reaction for which the proposed mechanism is a T cell response [46•].…”