IgE-mediated allergy to chlorhexidine

Garvey, Lene Heise; Krøigaard, Mogens; Poulsen, Lars K.; Skov, Per Stahl; Mosbech, H.; Venemalm, Lennart; Degerbeck, Fredrik; Husum, B.

doi:10.1016/j.jaci.2007.04.029

Cited by 159 publications

(115 citation statements)

References 24 publications

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“…Reactions are quite frequent in UK and Scandinavian countries [71,103,104], representing the 8.7%-9.6% of cause inducing perioperative anaphylaxis but relatively rare in France [22] perhaps because of its limited use in the operating room. The mechanism is IgE mediated and although reactions usually appear 20-30 minutes after its administration, onset and severity depend on the administration route, with cutaneous application rarely causing severe reaction [36]. However, when it is applied to mucous membranes (urinary catheters or oral cavity washes), or by parenteral routes (venous catheters or surgical meshes), the onset of clinical symptoms can be faster and more severe [36,104,105].…”

Section: C) Antiseptics and Sterilizersmentioning

confidence: 99%

“…The mechanism is IgE mediated and although reactions usually appear 20-30 minutes after its administration, onset and severity depend on the administration route, with cutaneous application rarely causing severe reaction [36]. However, when it is applied to mucous membranes (urinary catheters or oral cavity washes), or by parenteral routes (venous catheters or surgical meshes), the onset of clinical symptoms can be faster and more severe [36,104,105]. The appearance of anaphylaxis induced by povidone is unusual, and it is of note that no cross-reactivity with iodinated contrast media exists [12,70].…”

Section: C) Antiseptics and Sterilizersmentioning

confidence: 99%

See 1 more Smart Citation

Practical Guidelines for Perioperative Hypersensitivity Reactions

Laguna¹,

Archilla²,

Doña³

et al. 2018

J Investig Allergol Clin Immunol

105

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Perioperative hypersensitivity reactions constitute a first-line problem for anesthesiologists and allergists, so it is advisable that hospitals have a consensus protocol for the diagnosis and management of these reactions. However, this kind of protocols is not present in many hospitals, leading to problems in treatment, the communication of incidents and subsequent etiological diagnosis. In this document we present a systematic review of the available scientific evidence and provide general guidelines for the management of acute episodes and Resumen:Las reacciones de hipersensibilidad perioperatorias constituyen un problema de primera línea para los anestesiólogos y alergólogos, por lo que es recomendable que los hospitales tengan un protocolo de consenso para el diagnóstico y el tratamiento de estas reacciones. Sin embargo, este tipo de protocolos no está presente en muchos hospitales, lo que conlleva problemas en el tratamiento, la comunicación de incidentes y el posterior diagnóstico etiológico. Este documento ha sido creado por miembros del Comité de Alergia a Medicamentos de la Sociedad Española de Alergia e Inmunología Clínica (SEAIC) en colaboración con miembros de la Sociedad Española de Anestesia (SEDAR). Se ha realizado una revisión sistemática de la evidencia científica disponible y se proporcionan pautas generales para el manejo de episodios agudos y para la derivación de pacientes con reacciones de hipersensibilidad perioperatoria a los Servicios de Alergología. Se propone un algoritmo práctico para el diagnóstico etiológico y se brindan recomendaciones para el manejo de pacientes con reacciones alérgicas perioperatorias.

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Section: C) Antiseptics and Sterilizersmentioning

confidence: 99%

Section: C) Antiseptics and Sterilizersmentioning

confidence: 99%

Practical Guidelines for Perioperative Hypersensitivity Reactions

Laguna¹,

Archilla²,

Doña³

et al. 2018

J Investig Allergol Clin Immunol

105

View full text Add to dashboard Cite

show abstract

“…1,3,7,[12][13][14][15][16][17] However, some problems with CHG have been noted, including its suboptimal bactericidal kinetics (CHG was slower than another antiseptic) and rare anaphylactic reactions to it in humans. [25][26][27][28][29][30] Recently, a new compound, HM-242, was synthesized as a novel disinfectant. We found that HM-242 has broad-spectrum and fast-acting microbicidal activity in vitro.…”

Section: Discussionmentioning

confidence: 99%

In vitro evaluation of the antimicrobial activity of HM-242, a novel antiseptic compound

et al. 2009

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The antimicrobial activities of N 4 -octyl-6,6-dimethyl-N 2 -(4-methylbenzyl)-1,6-dihydro-1,3,5-triazine-2,4-diamine (HM-242), a novel synthetic compound, were compared with those of chlorhexidine gluconate (CHG). HM-242 was a more potent microbicide than CHG in vitro; however, its minimal inhibitory concentrations were similar. In particular, HM-242 killed various Grampositive bacteria, including methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecalis, both efficiently and rapidly. HM-242 also showed potent virucidal activity against enveloped viruses such as influenza virus and herpes simplex virus. These characteristics suggest that HM-242 may well be useful as an antiseptic.

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“…Due to toxicity, an allergic reaction to the antineoplastic drugs could not be verified by a skin prick test, and commercial specific immunoglobulin E (IgE) tests were not available. An in vitro histamine release test was, however, an alternative (1). A blood sample was therefore incubated with the suspected drugs (etoposide, taxoterere, CTX, 5-FU, oxaliplatin, carboplatin, topotecan, farmorubicin, and gemcitabin) each in 12 concentrations.…”

Section: Methodsmentioning

confidence: 99%