Anaphylaxis in children and adolescents: The European Anaphylaxis Registry

Grabenhenrich, Linus; Dölle, Sabine; Moneret-Vautrin, Anne; Köhli, Alice; Lange, Lars; Spindler, Thomas; Ruëff, Franziska; Nemat, Katja; Maris, Ioana; Roumpedaki, Eirini; Scherer, Kathrin; Ott, Hagen; Reese, Thomas J.; Mustakov, Tihomir B.; Lang, Roland; Fernández‐Rivas, Montserrat; Kowalski, Marek L.; Bilò, Maria Beatrice; Hourihane, Jonathan; Papadopoulos, Nikolaos G.; Beyer, Kirsten; Muraro, Antonella; Worm, Margitta

doi:10.1016/j.jaci.2015.11.015

Cited by 458 publications

(499 citation statements)

References 26 publications

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“…9 This was not observed in and related conditions in the ICD-11 framework. 10,11 In an attempt to validate this new section of the ICD-11 version pertaining to allergic and hypersensitivity conditions to capture anaphylaxis deaths, the Brazilian group finally reported a decrease in reporting of anaphylaxis deaths due to improvements in anaphylaxis classification and coding.…”

Section: Fatal Anaphylaxis In Children In France: Analysis Of Nationamentioning

confidence: 90%

Fatal anaphylaxis in children in France: Analysis of national data

Pouessel

Tanno

Claverie

et al. 2018

Pediatric Allergy Immunology

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Section: Fatal Anaphylaxis In Children In France: Analysis Of Nationamentioning

confidence: 90%

Fatal anaphylaxis in children in France: Analysis of national data

Pouessel

Tanno

Claverie

et al. 2018

Pediatric Allergy Immunology

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“…Alergija na proteine hrane se javlja kao posledica defekta ili insuficijencije T-ćelijske supresije i pokretanja jedne ili više hipersenzitivnih imunskih reakcija koje nastaju kao odgovor na antigensku stimulaciju [25]. Prema klasifikaciji Coombsa i Gella [22], hipersenzitivne reakcije se diferenciraju na četiri osnovna tipa i to: reaginski ili IgE posredovani (I), citotoksični (II), imunokompleksni (III) i T-celularni (IV).…”

Section: Uvodunclassified

“…U većini slučajeva one su blažeg ili srednje teškog stepena, ali su moguće i veoma teške IgE posredovane sistemske reakcije, nekad i fatalne [3,22,24,25]. Iako je za anafilaktični šok na hranu u preko 50% slučajeva odgovoran kikiriki, treba imati u vidu da se on javlja i na ostale visoko alergogene namirnice, pa i one van tog spiska [25]. Prema brzini ispoljavanja, odnosno tipu hipersenzitivnosti, neželjene pojave mogu biti ranog (reaginskog) ili kasnog (nereaginskog) tipa [24].…”

Section: Kliničke Manifestacije I Dijagnostikaunclassified

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Alergija na hranu u dečjoj dobi – klinički aspekt

Radlovic¹,

Lekovic²,

Radlovic

et al. 2017

Biomedicinska istraž.

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Kratak sadržajAlergija na hranu predstavlja čest i kontinuirano rastući problem. Iako je prisutna u svim životnim dobima, najčešće pogađa decu do tri godine, a posebno nasledno predisponiranu odojčad na veštačkoj ishrani. Sklonost neadekvatnoj imunskoj reakciji je neselektivnog karaktera, te je nutritivna alergija često multipla i u visokom stepenu udružena sa inhalacionom i/ili kontaktnom hipersenzitivnošću. Zbog antigenske bliskosti nekih vrsta hrane alergijska reakcija može biti i unakrsna, kao što je to slučaj sa kikirikijem, leguminozama i jezgrastim voćem ili kravljim, ovčjim i kozjim mlekom. Glavni nutritivni alergeni, odgovorni za preko 90% neželjenih reakcija ovog tipa, su proteini kravljeg mleka, jaja, kikirikija, jezgrastog voća, soje, pšeničnog brašna, ribe i morskih mekušaca, zglavkara i cefalopoda. Alergiju na hranu karakteriše veoma širok spektar kliničkih manifestacija. Moguće su i veoma teške sistemske reakcije, nekad i fatalne. Dijagnoza alergije na hranu se zasniva na detaljnoj ličnoj i porodičnoj anamnezi, kompletnom kliničkom pregledu i odgovarajućim laboratorijskim i drugim ispitivanjima prilagođenim tipu hipersenzitivnosti i karakteru tegoba ispitanika, a terapija na eliminacionoj dijeti. Značajan doprinos dijagnozi ima i pozitivan efekat eliminacione dijete. Mada je alergija na hranu kod dece u većini slučajeva prolazna, na neke od namirnica, kao što su kikiriki, jezgrasto voće, riba i morski mekušci, zglavkari i cefalopode, ona je najčešće doživotna.

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“…Food-allergic reactions may result in life-threatening anaphylaxis [2, 3], and peanut allergy (PA) in particular is the most frequent cause of such reactions. At present, no effective treatment of peanut allergy is approved by the regulatory authorities.…”

Section: Introductionmentioning

confidence: 99%

Evidence for a Role of TGF-β-Activated Kinase 1 and MAP3K7 Binding Protein 3 in Peanut-Specific T-Cell Responses

Saidova

Bublin

Schmidthaler

et al. 2019

Int Arch Allergy Immunol

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Peanut allergy is considered to be the most common cause for food-induced anaphylaxis. Currently, no approved treatment is available. Avoidance is the only measure to prevent anaphylactic reactions to peanuts. T-helper cells are of special importance for the sensitization process and the maintenance of allergic inflammation. Identifying markers of allergen-specific T-cell responses may help to develop novel treatment approaches. Therefore, we aimed to define new T-cell target genes in Ara h 2-specific T cells and to investigate the possibility of using them as biomarkers of peanut allergy in peripheral blood mononuclear cells (PBMCs). We performed whole mRNA array analysis (whole human genome oligo microarray) of in vitro expanded Ara h 2-specific T cells (CFSE^lowCD3⁺CD4⁺) from 5 peanut-allergic (PA) and 5 non-peanut-sensitized individuals. Expression of selected genes as a result of a two-step bioinformatic approach was confirmed in a second cohort by quantitative PCR. TGF-β- activated kinase 1 and MAP3K7 binding protein 3 (TAB3), calcium/calmodulin-dependent protein kinase type IV (CAMK4) and HemK methyltransferase family member 1 (HEMK1) were significantly upregulated in Ara h 2-specific T cells of PA patients. In addition, the expression of these genes was also assessed in unstimulated PBMCs from a cohort (n = 43) of PA, atopic non-PA, and nonatopic controls. Interestingly, in unstimulated PBMCs, TAB3 expression was significantly downregulated in PA patients compared to atopic non-PA individuals. Thus, TAB3 may play a significant role at the level of T-cell activation and may also be a candidate biomarker for PA.

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Anaphylaxis in children and adolescents: The European Anaphylaxis Registry

Cited by 458 publications

References 26 publications

Fatal anaphylaxis in children in France: Analysis of national data

Fatal anaphylaxis in children in France: Analysis of national data

Alergija na hranu u dečjoj dobi – klinički aspekt

Evidence for a Role of TGF-β-Activated Kinase 1 and MAP3K7 Binding Protein 3 in Peanut-Specific T-Cell Responses

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