Alergija na hranu u dečjoj dobi – klinički aspekt

Radlovic, Nedeljko; Lekovic, Zoran; Radlovic, Vladimir; Mladenovic, Marija; Vuletic, Biljana; Simić, Dušica; Petrović-Tepić, Snežana

doi:10.7251/bii1702208r

Cited by 1 publication

(1 citation statement)

References 21 publications

(70 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This study was therefore one of the first to confirm the benign nature of the condition and advocated the use Gilbert's "syndrome" as opposed to the previously used Gilbert's "disease" (3). Despite these conclusions, the coexistence of elevated bilirubin, and conditions causing abdominal pain and fever in children has been documented (84), although the authors note that reported symptoms are unlikely caused by GS but coincide with hyperbilirubinemia. These findings are not surprising given that stress responses are often typified by increased heme catabolism or reduced bilirubin excretion, which increase circulating concentrations (108).…”

Section: Potential Negative Consequences Of Benign Hyperbilirubinemiamentioning

confidence: 97%

Bilirubin acts as a multipotent guardian of cardiovascular integrity: more than just a radical idea

Bulmer

Bakrania

Toit

et al. 2018

American Journal of Physiology-Heart and Circulatory Physiology

View full text Add to dashboard Cite

Bilirubin, a potentially toxic catabolite of heme and indicator of hepatobiliary insufficiency, exhibits potent cardiac and vascular protective properties. Individuals with Gilbert's syndrome (GS) may experience hyperbilirubinemia in response to stressors including reduced hepatic bilirubin excretion/increased red blood cell breakdown, with individuals usually informed by their clinician that their condition is of little consequence. However, GS appears to protect from all-cause mortality, with progressively elevated total bilirubin associated with protection from ischemic heart and chronic obstructive pulmonary diseases. Bilirubin may protect against these diseases and associated mortality by reducing circulating cholesterol, oxidative lipid/protein modifications, and blood pressure. In addition, bilirubin inhibits platelet activation and protects the heart from ischemia-reperfusion injury. These effects attenuate multiple stages of the atherosclerotic process in addition to protecting the heart during resultant ischemic stress, likely underpinning the profound reduction in cardiovascular mortality in hyperbilirubinemic GS. This review outlines our current knowledge of and uses for bilirubin in clinical medicine and summarizes recent progress in revealing the physiological importance of this poorly understood molecule. We believe that this review will be of significant interest to clinicians, medical researchers, and individuals who have GS.

show abstract

Section: Potential Negative Consequences Of Benign Hyperbilirubinemiamentioning

confidence: 97%