Anaphylaxis from bee pollen supplement

Jagdis, Amanda; Sussman, Gordon

doi:10.1503/cmaj.112181

Cited by 30 publications

(14 citation statements)

References 6 publications

(11 reference statements)

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“…Jagdis and Sussman described a case of anaphylactic reaction (eyelids, throat and lips swelling, shortness of breath, swallowing difficulties, feeling faint) in a 30-year-old woman with seasonal allergic rhinitis after consumption of a second dose of bee pollen. The skin tests revealed strong reactivity to bee pollen [12]. Similar case was also reported by Choi et al: 40-year-old male with history of seasonal allergic rhinitis had anaphylactic reaction after ingestion of a tablespoon of bee pollen [13].…”

Section: Can Bee Pollen Be a Life Threat?supporting

confidence: 84%

Bee pollen in allergy and immunology. Short review

et al. 2017

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S u m m a r yBee pollen is a natural resource -pollen collected by bees and stored in the beehive with various bee enzymes added as it is a mixture of plants pollen and bee saliva. It is rich source of various nutrients, among them exogenous amino acids. Therefore, it can be a good and natural dietary supplement. New possibilities for bee pollen usage arise every day, yet it can also be a threat. Although bee pollen can act as an immunostimulant and anti-allergic agent, it is also and maybe even primarily allergic or cross-reactive with many allergens. A number of bee pollen allergy cases was described worldwide. A caution is therefore needed before ingestion or any other form of administration, especially in case of children or individuals with atopic predispositions. Anti-allergic attributes and immunostimmulation ability still need further research. key words: bee pollen, bee pollen allergy, bee pollen immunology Bee pollen -what is it exactly?Bee pollen is a natural resource -a pollen collected by bees and stored in the beehive with various bee enzymes added as it is a mixture of plants pollen and bee saliva. Its chemical compositions varies, depending on the plant source, but it has been proved to contain about 250 different chemical substancesamino acids, vitamins, micro-and macroelements, carbohydrates, nucleic acids, triglycerides, phospholipids, flavonoids [1,2]. About 20% of bee pollen is

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Section: Can Bee Pollen Be a Life Threat?supporting

confidence: 84%

Bee pollen in allergy and immunology. Short review

et al. 2017

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“…The releasing of histamine from mast cells induced by the serum-containing anti-IgE antibodies was inhibited by pollen by 62% (Ishikawa et al, 2008). However, one case study has reported the potential allergic reactions when ingested BP by patients has pollen allergy (Jagdis & Sussman, 2012).…”

Section: Introductionmentioning

confidence: 98%

Antioxidant and hepatorenal protective effects of bee pollen fractions against propionic acid‐induced autistic feature in rats

AlSalem

Al‐Yousef

Ashour

et al. 2020

Food Science & Nutrition

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In the brain, propionic acid (PA) can cross cell membranes and accumulate within cells, leading to intracellular acidification, which may alter neurotransmitter release (NT), communication between neurons, and behavior. Such elevation in levels of PA constitutes a neurodevelopmental metabolic disorder called propionic acidemia, which could clinically manifest as autism. The purpose of this study was to investigate the protective effects of different fractions of bee pollen (BP) on PA‐induced autism in rats, and to evaluate their effects on the expression of liver and renal biomarkers. Groups of rats received treatments of different fractions of BP at a dose of 250 mg/kg of body weight/day for a period of 1 month. Normal control group I and group II were orally administered with phosphate‐buffered saline and propionic acid, respectively, for 3 days. BP contains various health‐promoting phenolic components. Different fractions of BP administered pre‐ and post‐treatment with PA showed significant reduction in the levels of liver and renal biomarkers (p < .05). Also, a significant enhancement in the levels of glutathione S‐transferase (GST), catalase CAT), and ascorbic acid (VIT C) was observed. Supplementation with BP significantly reduced biochemical changes in the liver, kidneys, and brain of rats with PA‐induced toxicity. It exhibited protective effects against oxidative damage and reactive oxygen species produced by PA‐induced adverse reactions in rats. Taken together, our study shows that BP possesses protective effects in PA‐induced liver and kidney damage.

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“… 1 2 There has been a few reports of bee pollen-induced acute allergic reactions, including anaphylaxis. 3 4 5 6 7 8 9 10 Interestingly, severe allergic reactions could develop after ingestion of insect-pollinated pollens in patients sensitized to wind-pollinated plants, 3 5 7 as honey bees collect pollen from insect-pollinated flowers. Cohen et al 3 reported 3 patients with allergic rhinitis sensitized to ragweed who developed acute allergic reactions after ingestion of bee pollen containing dandelion, suggesting cross-allergenicity between wind-pollinated ragweed and insect-pollinated dandelion.…”

Section: Introductionmentioning

confidence: 99%

“…However, the presence of airborne pollens in bee pollen was suggested as another possible mechanism of bee-pollen-induced allergic reactions. 10 …”

Section: Introductionmentioning

confidence: 99%

Bee Pollen-Induced Anaphylaxis: A Case Report and Literature Review

Choi

Jang

et al. 2015

Allergy Asthma Immunol Res

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Bee pollen is pollen granules packed by honey bees and is widely consumed as natural healthy supplements. Bee pollen-induced anaphylaxis has rarely been reported, and its allergenic components have never been studied. A 40-year-old male came to the emergency room with generalized urticaria, facial edema, dyspnea, nausea, vomiting, abdominal pain, and diarrhea 1 hour after ingesting one tablespoon of bee pollen. Oxygen saturation was 91%. His symptoms resolved after injection of epinephrine, chlorpheniramine, and dexamethasone. He had seasonal allergic rhinitis in autumn. Microscopic examination of the bee pollen revealed Japanese hop, chrysanthemum, ragweed, and dandelion pollens. Skin-prick with bee pollen extracts showed positive reactions at 0.1 mg/mL (A/H ratio > 3+). Serum specific IgE to ragweed was 25.2, chrysanthemum 20.6, and dandelion 11.4 kU/L; however, Japanese hop, honey-bee venom and yellow-jacket venom were negative (UniCAP®, Thermo Fisher Scientific, Uppsala, Sweden). Enzyme-linked immunosorbent assay (ELISA) confirmed serum specific IgE to bee-pollen extracts, and an ELISA inhibition assay for evaluation of cross-allergenicity of bee pollen and other weed pollens showed more than 90% of inhibition with chrysanthemum and dandelion and ~40% inhibition with ragweed at a concentration of 1 µg/mL. Sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) and IgE-immunoblot analysis revealed 9 protein bands (11, 14, 17, 28, 34, 45, 52, 72, and 90 kDa) and strong IgE binding at 28-34 kDa, 45 and 52 kDa. In conclusion, healthcare providers should be aware of the potential risk of severe allergic reactions upon ingestion of bee pollen, especially in patients with pollen allergy.

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Anaphylaxis from bee pollen supplement

Cited by 30 publications

References 6 publications

Bee pollen in allergy and immunology. Short review

Bee pollen in allergy and immunology. Short review

Antioxidant and hepatorenal protective effects of bee pollen fractions against propionic acid‐induced autistic feature in rats

Bee Pollen-Induced Anaphylaxis: A Case Report and Literature Review

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