Anaphylactic shock induced by intravenous gadopentetate dimeglumine

Tardy, B.; Guy, Christopher L.; Barral, G; Page, Yves; Ollagnier, M.; Bertrand, J C

doi:10.1016/0140-6736(92)91102-e

Cited by 55 publications

(29 citation statements)

References 3 publications

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“…It must be remembered, however, that although gadolinium is a safe contrast medium, there is a reported the rate of 0.0003% of severe anaphylactic reactions in the literature [11], and one paper describes a much higher rate of adverse reactions (0.01%) [12]. Therefore, the management protocols for reactions to gadolinium-based contrast Fig.…”

Section: Discussionmentioning

confidence: 98%

Hysterosalpingography with gadolinium

Ferraiolo

Castelletti

et al. 2004

Eur Radiol

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Section: Discussionmentioning

confidence: 98%

Hysterosalpingography with gadolinium

Ferraiolo

Castelletti

et al. 2004

Eur Radiol

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“…However, nephrogenic systemic fibrosis due to MR contrast media has been reported (2,3). Cases of severe immediate hypersensitivity reactions such as anaphylaxis to MR contrast media also have been reported (4)(5)(6). Because the use of MR imaging has increased, several investigations on the safety of MR contrast media have been done (1,(7)(8)(9)(10)(11).…”

Section: Study Subjectsmentioning

confidence: 99%

Immediate Hypersensitivity Reaction to Gadolinium-based MR Contrast Media

Jung¹,

Kang²,

Kim³

et al. 2012

Radiology

219

165

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Purpose:To determine the incidence and risk factors of immediate hypersensitivity reactions to gadolinium-based magnetic resonance (MR) contrast agents. Materials and Methods:Institutional review board approval and a waiver of informed consent were obtained. A retrospective study of patients who had been given gadolinium-based MR contrast media between August 2004 and July 2010 was performed by reviewing their electronic medical records. In addition to data on immediate hypersensitivity reaction, the kinds of MR contrast media and demographic data including age, sex, and comorbidity were collected. To compare the groups, the x 2 test, Fisher exact test, x 2 test for trend, Student t test, analysis of variance test, and multiple logistic regression test were performed. Results:A total of 112 immediate hypersensitivity reactions (0.079% of 141 623 total doses) were identified in 102 patients (0.121% of 84 367 total patients). Among the six evaluated MR contrast media, gadodiamide had the lowest rate (0.013%) of immediate hypersensitivity reactions, while gadobenate dimeglumine had the highest rate (0.22%). The rate for immediate hypersensitivity reactions was significantly higher in female patients (odds ratio = 1.687; 95% confidence interval: 1.143, 2.491) and in patients with allergies and asthma (odds ratio = 2.829; 95% confidence interval: 1.427, 5.610). Patients with a previous history of immediate hypersensitivity reactions had a higher rate of recurrence after reexposure to MR contrast media (30%) compared with the incidence rate in total patients (P , .0001). The incidence of immediate hypersensitivity reactions increased depending on the number of times patients were exposed to MR contrast media (P for trend = .036). The most common symptom was urticaria (91.1%), and anaphylaxis occurred in 11 cases (9.8%). The mortality rate was 0.0007% because of one fatality. Conclusion:The incidence of immediate hypersensitivity reactions to MR contrast media was 0.079%, and the recurrence rate of hypersensitivity reactions was 30% in patients with previous reactions.q RSNA, 2012 Supplemental material: http://radiology.rsna.org/lookup /suppl

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“…[47][48][49] The incidence is very low and of the order of 0.01-0.031%. 1,50,51 This rate is significantly less than the incidence of anaphylactic reaction that occurs with iodinated contrast which is approximately 0.031-0.157%.…”

Section: Anaphylaxismentioning

confidence: 99%