Anaphylactic shock induced by <i>Codonopsis lanceolata</i>, traditional Chinese medicine in a patient with allergic rhinitis

Hur, Gyu-Young; Choi, Gyu Seong; Park, H.‐J.; Ye, Y.‐M.; Park, H.‐S.

doi:10.1111/j.1398-9995.2008.01837.x

Cited by 14 publications

(6 citation statements)

References 3 publications

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“…Codonopsis lancelata L. (Campanulaceae) has long been prescribed in traditional folk medicine with therapeutic properties on bronchitis, cough, and spasm in Korea, Japan and China (Hur et al, 2008). Furthermore, the dried roots of C. lanceolata are often used as a type of "recovery pill" to aid those who are weakened by disease, surgery or other medical therapy, blood loss or other injury, or childbirth (Fratkin et al, 1974).…”

Section: Introductionmentioning

confidence: 99%

Inhibitory effect of saponin fraction from Codonopsis lanceolata on immune cell-mediated inflammatory responses

Byeon

Choi²,

Hong

et al. 2009

Arch. Pharm. Res.

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Saponin components are known to be pharmaceutically, cosmetically and nutraceutically valuable principles found in various herbal medicine. In this study, we evaluated the inhibitory role of saponin fraction (SF), prepared from C. lanceolata, an ethnopharmacologically famous plant, on various inflammatory responses managed by monocytes, macrophages, lymphocytes and mast cells. SF clearly suppressed the release of nitric oxide (NO) and tumor necrosis factor (TNF)-alpha, but not prostaglandin E(2) (PGE(2)). While this fraction did not scavenge the reactivity of SNP-induced radicals in RAW264. 7 cells, it negatively modulated the phagocytic uptake of macrophages treated with FITC-dextran. Interestingly, SF completely diminished cell-cell adhesion events induced by both CD29 and CD43, but not cell-fibronectin adhesion. Concanavalin (Con) A [as well phytohemaglutinin A (PHA)]-induced proliferation of splenic lymphocytes as well as interferon (IFN)-gamma production were also clearly suppressed by SF treatment. Finally, SF also significantly blocked the degranulation process of mast cell line RBL-2H3 cell as assessed by DNP-BSA-induced beta-hexosaminidase activity. The anti-inflammatory activities of SF on NO production seemed to be due to inhibition of nuclear factor (NF)-kappaB activation signaling, since it blocked the phosphorylation of inhibitor of kappaB (IkappaB)alpha as well as inducible NO synthase (iNOS) expression. Therefore, these results suggest that SF may be considered as a promising herbal medicine with potent anti-inflammatory actions.

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Section: Introductionmentioning

confidence: 99%

Inhibitory effect of saponin fraction from Codonopsis lanceolata on immune cell-mediated inflammatory responses

Byeon

Choi²,

Hong

et al. 2009

Arch. Pharm. Res.

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“…It is considered to be an antidote for multiple diseases in traditional folk medicine (Wang et al, 1995) including the anticancer properties (Pulla et al, 2008;Purev et al, 2008). Recently, physicians have reported that C. lanceolata causes anaphylaxis in humans (Hur et al, 2008). Environmental changes and indiscriminate harvesting have resulted in the extinction of the species in nature; however, breeders have started cultivating C. lanceolata to meet the demand for this plant (Guo et al, 2006).…”

Section: Therapeutic Potentialmentioning

confidence: 99%

Codonopsis lanceolata: A Review of Its Therapeutic Potentials

Hossen

Kim

et al. 2015

Phytotherapy Research

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Codonopsis lanceolata (Campanulaceae) is dicotyledonous herbaceous perennial plant, predominantly found in Central, East, and South Asia. This plant has been widely used in traditional medicine and is considered to have medicinal properties to treat diseases and symptoms such as bronchitis, coughs, spasm, psychoneurosis, cancer, obesity, hyperlipidemia, edema, hepatitis, colitis, and lung injury. C. lanceolata contains many biologically active compounds, including polyphenols, saponins, tannins, triterpene, alkaloids, and steroids, which contribute to its numerous pharmacological activities. Through systematic studies, the pharmacological actions of these compounds have been revealed. Therapeutic potentialities of C. lanceolata and its previously reported molecular mechanisms are described in this review.

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“…Historically, Codonopsis lanceolata L. (Campanulaceae) has been used for traditional folk medicine with therapeutic properties on bronchitis, cough, and spasm in Korea, Japan and China (Hur et al, 2008). Furthermore, the root parts of C. lanceolata are often prescribed as a type of "recovery pill" to aid those who are weakened by injury, blood loss, surgery, childbirth, diseases or other medical therapy (Fratkin et al, 1974).…”

Section: Introductionmentioning

confidence: 99%

Protective effect of stress-induced liver damage by saponin fraction from Codonopsis lanceolata

et al. 2009

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Saponins are valuable principles found in various herbal medicine with pharmaceutical, cosmetical and nutraceutical merits. In this study, we evaluated the protective role of saponin fraction (Cl-SF), prepared from Codonopsis lanceolata, an ethnopharmacologically famous plant in Korea, China and Japan, on water immersion stress-induced liver damage and radical generation. Cl-SF clearly decreased the up-regulated levels of serum glutamate-oxalacetate transaminase and glutamate-pyruvate-transaminase induced by water-immersed stress conditions. Furthermore, Cl-SF seemed to block the stress-induced radicals. Thus, Griess and DPPH assays revealed that Cl-SF significantly suppressed both radical generation in sodium nitroprusside-treated RAW264.7 cells and nitric oxide production in LPS-treated RAW264.7 cells. Therefore, these results suggest that Cl-SF may be considered as a promising stress-regulatory principle with radical scavenging actions.

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Anaphylactic shock induced by Codonopsis lanceolata, traditional Chinese medicine in a patient with allergic rhinitis

Cited by 14 publications

References 3 publications

Inhibitory effect of saponin fraction from Codonopsis lanceolata on immune cell-mediated inflammatory responses

Inhibitory effect of saponin fraction from Codonopsis lanceolata on immune cell-mediated inflammatory responses

Codonopsis lanceolata: A Review of Its Therapeutic Potentials

Protective effect of stress-induced liver damage by saponin fraction from Codonopsis lanceolata

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