Anaphylactic Shock during Hysteroscopy Using Hyskon Solution: Case Report and Review of Adverse Reactions and Their Treatment

Perlitz, Yuri; Oettinger, Moshe; Karam, Keresh; Lipshitz, B.; Simon, Kurt

doi:10.1159/000292042

Cited by 9 publications

(3 citation statements)

References 11 publications

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“…Whether fluid shifts caused an electrolyte disturbance is more difficult to ascertain, although fewer deaths occurred in a concentration smaller than that used in the CD gel. There are reports in the literature of dextran causing allergic reactions [22], although no animal in the study exhibited any overt signs of an allergic reaction.…”

Section: Discussionmentioning

confidence: 63%

Use of a Modified Chitosan–Dextran Gel to Prevent Peritoneal Adhesions in a Rat Model

Lauder

Garcea

Strickland

et al. 2011

Journal of Surgical Research

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Section: Discussionmentioning

confidence: 63%

Use of a Modified Chitosan–Dextran Gel to Prevent Peritoneal Adhesions in a Rat Model

Lauder

Garcea

Strickland

et al. 2011

Journal of Surgical Research

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“…There is no one product that is currently available without certain drawbacks. This may be a result of a sensitivity to the product itself, for example with Hyskon® where patients reacted to the antigenic properties of the constituents [127]. Alternatively, the product may increase the incidence of anastomotic leakage or wound dehiscence such as with Intergel®.…”

Section: Methods Of Adhesion Reductionmentioning

confidence: 99%

Abdominal Adhesion Prevention: Still a Sticky Subject

et al. 2010

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Background: Adhesion formation remains an almost inevitable consequence of abdominal procedures, potentially resulting in significant morbidity and mortality. There is an ongoing need to evaluate current understanding of adhesion formation and products aimed at prevention. Failure to keep up to date with adhesion treatment may subject clinicians to a greater medico-legal risk. Design: Review of published studies exploring the problem of peritoneal adhesion formation. This encompasses the underlying processes of adhesion formation combined with general approaches to reduce formation. An overview of products trialled to prevent formation in both the animal model and clinical setting describes products of scientific interest and commercial success. Results: Advances in surgical technique, such as laparoscopic surgery, can help minimize the probability of adhesion formation. Currently barrier products, whilst reducing adhesion formation, have not been shown to reduce the risk of readmission with complications related to adhesions. Hybrid products may improve upon this situation. Conclusions: No single approach has been wholly satisfactory in reducing adhesions. Research into the processes driving adhesion formation is providing exciting new targets for therapeutic agents. It would seem plausible that with many promising avenues of research a revolutionary agent to reduce the incidence of adhesional small bowel obstruction may result.

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“…However, the duration of survival was not addressed in this study. Furthermore, dextran may not be a suitable option for enhancing hypothermia survival because of its relatively short-lasting effect (2-4 h) (26) and its antigenicity due to its bacterial origin (22). In the present study, we used hetastarch, another volume expander, but with much longer duration of action (Ͼ24 h) (26) and excellent clinical safety record (25) to enhance hypothermia survival.…”

Section: Discussionmentioning

confidence: 99%

Effects of hetastarch and mannitol on prolonging survival in stable hypothermia in rats

Lee

Westly

Wang

2000

American Journal of Physiology-Regulatory, Integrative and Comp

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In rats, prolonged stable hypothermia ( approximately 24 h at body temperature of 19 degrees C) is characterized by a time-dependent increase in hematocrit, plasma osmolality, and red blood cell fragility and a decrease in plasma volume. These changes impede tissue microcirculation and could limit survival. As a countermeasure, we used plasma volume expanders of both long (hetastarch)- and short-lasting (mannitol) characteristics to improve microcirculation and hopefully hypothermia survival. Infusion of 6% hetastarch at hour 3 in hypothermia significantly (P < 0.05) enhanced survival over saline control (33.5 vs. 23.8 h); a significant delay in the increases of hematocrit and cell fragility was also observed compared with those in saline controls. Treating the animal with 6% hetastarch at hour 20 during hypothermia caused a similar but less-effective improvement in survival. In contrast, treating the rats with 6% mannitol at hour 3 or 20 during hypothermia failed to enhance survival over saline control, although transient improvement in plasma volume was observed. Our results indicate that by using a long-lasting volume expander, which tends to better maintain plasma volume and rheological parameters governing microcirculation than does saline or a short-lasting volume expander, hypothermia survival can be significantly improved.

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Anaphylactic Shock during Hysteroscopy Using Hyskon Solution: Case Report and Review of Adverse Reactions and Their Treatment

Cited by 9 publications

References 11 publications

Use of a Modified Chitosan–Dextran Gel to Prevent Peritoneal Adhesions in a Rat Model

Use of a Modified Chitosan–Dextran Gel to Prevent Peritoneal Adhesions in a Rat Model

Abdominal Adhesion Prevention: Still a Sticky Subject

Effects of hetastarch and mannitol on prolonging survival in stable hypothermia in rats

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