Use of a Modified Chitosan–Dextran Gel to Prevent Peritoneal Adhesions in a Rat Model

Lauder, Chris I W; Garcea, Giuseppe; Strickland, Andrew; Maddern, Guy J.

doi:10.1016/j.jss.2010.06.028

Cited by 82 publications

(66 citation statements)

References 25 publications

(23 reference statements)

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“…Upon autopsy on postoperative day 7 and repeated laparotomy, the areas of the cecum and abdominal sidewall were evaluated for macroscopic adhesion by 2 independent observers according to scoring schemes by Lauder et al [20] and Hoffmann et al [23], as shown in tables 1 and 2. Photographs of the affected areas were taken from each animal for documentation (20.0-megapixel digital camera, Sony Cyber-shot DSC-RX100).…”

Section: Methodsmentioning

confidence: 99%

“…Although several nonabsorbable synthetic materials such as silicone and polytetrafluoroethylene have been shown to be effective, bioabsorbable materials basing on oxidized cellulose or polyethylene glycol or other degradable components are preferred clinically for several reasons: there is no necessity of secondary surgery for removal, no need to consider long-term biocompatibility of materials, and no risk of encapsulation, which might also evoke tissue adhesion [11,18]. These problems do not account for absorbable devices; however, their efficiency still is under debate [11,19,20]. Although many medical devices either in liquid, gel, or membrane forms have reached the market with some economic success, no single product has been wholly satisfactory yet [11,20].…”

Section: Introductionmentioning

confidence: 99%

“…These problems do not account for absorbable devices; however, their efficiency still is under debate [11,19,20]. Although many medical devices either in liquid, gel, or membrane forms have reached the market with some economic success, no single product has been wholly satisfactory yet [11,20]. …”

Section: Introductionmentioning

confidence: 99%

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Evaluation of 4DryField® PH as Adhesion Prevention Barrier Tested in an Optimized Adhesion Model in Rats

Poehnert¹,

Abbas

Kreipe

et al. 2015

Eur Surg Res

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Background: Adhesions due to pelvic/abdominal surgery are a common serious pathology possibly entailing severe complications. This study investigates the adhesion prevention capability of the novel starch-based agent 4DryField® PH, which together with saline solution forms a barrier gel. Herein, an optimized adhesion model (OPAM) inducing severe adhesions/agglutinations with high reproducibility was used. Methods: In 19 Lewis rats, a 1 × 2 cm abdominal wall defect was created, the peritoneum of the neighboring cecum was abraded, and both injured areas were approximated by suture. Rats were randomized to control (n = 10) or 4DryField PH treatment (n = 9) groups. Another 8 rats had sham surgery for safety assessment of 4DryField PH. At day 7, the quantity and quality of adhesions were assessed macro-/microscopically and evaluated statistically. Results: 4DryField PH treatment significantly reduced the incidence and severity of adhesions as verified by significantly improved adhesion scorings (0.4 vs. 4.5; 1.1 vs. 9). Histology revealed reconstitution of the cecum and abdominal wall including regeneration of the visceral/parietal peritoneum. In sham-operated rats, 4DryField PH did not induce adhesion formation. Conclusions: 4DryField PH gel was highly effective in preventing adhesions. Histologically, the injured cecum and abdominal wall regenerated well in the presence of 4DryField PH. Considering the severity of OPAM trauma, the potential of 4DryField PH to prevent adhesions can be rated excellent.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Evaluation of 4DryField® PH as Adhesion Prevention Barrier Tested in an Optimized Adhesion Model in Rats

Poehnert¹,

Abbas

Kreipe

et al. 2015

Eur Surg Res

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“…Biological films or gels containing hyaluronan, modified chitosan-dextran, or carboxymethyl chitosan have been used with some success in preventing or decreasing intra-abdominal adhesions abrasion and anastomosis models in rats (23,69,99,139).…”

Section: Relevance Of Animal Models To Human Intestinal Fibrosismentioning

confidence: 99%

Animal models of intestinal fibrosis: new tools for the understanding of pathogenesis and therapy of human disease

Rieder

Kessler

Sans

et al. 2012

American Journal of Physiology-Gastrointestinal and Liver Physi

121

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Fibrosis is a serious condition complicating chronic inflammatory processes affecting the intestinal tract. Advances in this field that rely on human studies have been slow and seriously restricted by practical and logistic reasons. As a consequence, well-characterized animal models of intestinal fibrosis have emerged as logical and essential systems to better define and understand the pathophysiology of fibrosis. In point of fact, animal models allow the execution of mechanistic studies as well as the implementation of clinical trials with novel, pathophysiology-based therapeutic approaches. This review provides an overview of the currently available animal models of intestinal fibrosis, taking into consideration the methods of induction, key characteristics of each model, and underlying mechanisms. Currently available models will be classified into seven categories: spontaneous, gene-targeted, chemical-, immune-, bacteria-, and radiation-induced as well as postoperative fibrosis. Each model will be discussed in regard to its potential to create research opportunities to gain insights into the mechanisms of intestinal fibrosis and stricture formation and assist in the development of effective and specific antifibrotic therapies.

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“…Many pharmacologic agents in the form of liquids, gels and solids have been implicated in the prevention of intra-abdominal adhesions. These agents are believed to act as mechanical barriers between peritoneal surfaces, and include agents such as modified chitosan-dextran gel, [25] nitric oxide, a Chinese medicinal compound known as Changtong oral liquid, [7] intravenous melatonin, [2] a combination of t-PA and phosphatidylcholine, [26] and poly(ethylene glycol)-poly(ε-caprolactone)-poly(ethylene glycol) (PEG-PCL-PEG, PECE) hydrogel. [6] Previously evaluated adhesion barriers include Seprafilm ® II [19] and polyethylene glycol spray (SprayGel).…”

Section: Discussionmentioning

confidence: 99%

The protective effect of ClinOleic against post-surgical adhesions

Altınel¹,

Taşpinar²,

Özgüç³

et al. 2014

Ulus Travma Acil Cerrahi Derg

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Use of a Modified Chitosan–Dextran Gel to Prevent Peritoneal Adhesions in a Rat Model

Cited by 82 publications

References 25 publications

Evaluation of 4DryField® PH as Adhesion Prevention Barrier Tested in an Optimized Adhesion Model in Rats

Evaluation of 4DryField® PH as Adhesion Prevention Barrier Tested in an Optimized Adhesion Model in Rats

Animal models of intestinal fibrosis: new tools for the understanding of pathogenesis and therapy of human disease

The protective effect of ClinOleic against post-surgical adhesions

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