Anaphylactic Release of Histamine from Guinea Pig Skin &lt;i&gt;in vitro&lt;/i&gt;

Yeoh, T. S.; Tay, C.H.; Greaves, Malcolm W.

doi:10.1159/000230628

Cited by 6 publications

(2 citation statements)

References 1 publication

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“…Three weeks after injection the animals were killed by stunning and exsanguination, and the abdominal skin was shaved and separated from subcutaneous tissues. Slices of approximately 500 //m thickness were obtained with a hand microtome as described by Yeoh, Tay & Greaves (1972). Samples were prepared containing five to six slices each in Tyrodc solution.…”

Section: Histamine Releasementioning

confidence: 99%

Oxatomide: in vitro assessment of antagonistic activity, and effects on histamine release and enzymatic histamine degradation in skin

et al. 1980

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The antagonistic activity of oxatomide, and its effects on evoked histamine release and histamine-N-methyl transferase activity in skin, have been studied. Oxatomide antagonizes H1 activity in a dose-dependent but non-competitive manner. It also shows some atropine-like activity. Oxatomide did not cause detectable inhibition of antigen-stimulated histamine release from skin slices of sensitized guinea-pigs although the possibility that oxatomide may cause weak inhibition could not be excluded. In the presence of low concentrations of histamine, oxatomide suppressed human skin histamine-N-methyl transferase, but in the presence of higher substrate concentrations it enhanced activity of this enzyme. These observations, which were limited by the poor solubility of oxatomide in aqueous media, should encourage further in vivo studies of oxatomide's histamine-suppressing properties in the human subjects.

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Section: Histamine Releasementioning

confidence: 99%

Oxatomide: in vitro assessment of antagonistic activity, and effects on histamine release and enzymatic histamine degradation in skin

et al. 1980

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“…Since then the effect of DCG on anaphylactic release of histamine and other spasmogens has been studied in several species and tissues. We have recent ly studied some simple characteristics of anaphylactic histamine release from guinea pig skin in vitro [Yeoh et al, 1972] and we report here the effect of DCG on histamine released from guinea pig skin slices in 3 sit uations: spontaneous release, liberation by compound 48/80 and release evoked by specific antigen.…”

Section: Introductionmentioning

confidence: 99%