Anaphylactic Reaction to Mannitol

Spaeth, George L.; Spaeth, Edmund B.; Spaeth, Philip G.; Lucier, Alfred C.

doi:10.1001/archopht.1967.00980030585004

Cited by 29 publications

(12 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…14 Systemic hyperosmotic agents can cause metabolic disturbance such as acidosis, pulmonary oedema and congestive heart failure, acute renal failure, and even intracranial haemorrhage and anaphylactic reaction. 15,16 For these reasons, current medical regimens to control IOP in acute phacomorphic angle-closure patients are not ideal.…”

Section: Introductionmentioning

confidence: 99%

Immediate argon laser peripheral iridoplasty (ALPI) as initial treatment for acute phacomorphic angle-closure (phacomorphic glaucoma) before cataract extraction: a preliminary study

Tham

Lai

Poon

et al. 2004

Eye

View full text Add to dashboard Cite

Purpose To study the safety and efficacy of immediate argon laser peripheral iridoplasty (ALPI) as initial treatment of acute phacomorphic angle-closure (phacomorphic glaucoma) before cataract extraction. Methods In all, 10 consecutive patients with acute phacomorphic angle-closure and intraocular pressure (IOP) X40 mmHg were recruited into the study. Each patient received topical atropine (1%) and timolol (0.5%), and immediate ALPI as initial treatment. The IOP at 15, 30, 60, and 120 min, and then 1 day, after ALPI were documented by applanation tonometry. Systemic IOP-lowering drugs were only started if IOP remained above 40 mmHg at 2 h after ALPI. Cataract extraction was subsequently performed as definitive treatment. Results In total, 10 patients (five male, five female), with a mean age7SD of 73.1710.3 years were recruited. Mean duration of symptomatic attack was 1287232 h. After ALPI, the mean IOP was reduced from 56.1712.5 to 45.3714.5 mmHg at 15 min, 37.677.5 mmHg at 30 min, 34.279.7 mmHg at 60 min, 25.578.7 mmHg at 120 min, and 13.674.2 mmHg at 1 day. In one patient, systemic acetazolamide was administered, because the IOP remained above 40 mmHg at 2 h after ALPI. All 10 patients had uncomplicated cataract extraction performed within 4 days after ALPI. No complications from the laser procedure were encountered.Conclusion Immediate ALPI, replacing systemic antiglaucomatous medications, appeared to be safe and effective as first-line treatment of acute phacomorphic angle-closure.

show abstract

Section: Introductionmentioning

confidence: 99%

Immediate argon laser peripheral iridoplasty (ALPI) as initial treatment for acute phacomorphic angle-closure (phacomorphic glaucoma) before cataract extraction: a preliminary study

Tham

Lai

Poon

et al. 2004

Eye

View full text Add to dashboard Cite

show abstract

“…Other low-molecular-weight sugars have been reported as allergens causing anaphylaxis [1–5]. In general, the capability of low-molecular-weight elements to cause sensitization depends on their binding to proteins to form a hapten-carrier complex.…”

Section: Discussionmentioning

confidence: 99%

“…Sugar alcohols rarely cause hypersensitivity reactions, although there have been reports of reactions to mannitol [1–4] and erythritol [5]. Maltitol has not been previously described as an agent involved in immediate hypersensitivity reactions.…”

Section: Introductionmentioning

confidence: 99%

A Case of Immediate Hypersensitivity Reaction to Maltitol

Trabado

Hijón

García-Trujillo

et al. 2017

Case Reports in Medicine

View full text Add to dashboard Cite

Background Maltitol is a sugar alcohol that is frequently used as a noncaloric sweetener, although it is also used as an excipient, a plasticizer in gelatin capsules, and an emollient. It has not been previously described as an agent involved in immediate hypersensitivity reactions. Methods We report on an anaphylactoid reaction with pharyngeal occlusion suffered by a 60-year-old man after ingestion of a candy containing maltitol syrup. A prick-to-prick test was performed with the candy and maltitol powder. Other allergens were excluded as causative agents of the adverse reaction, although the patient refused to undergo an oral challenge test with the candy. A basophil activation test (BAT) was performed with maltitol powder, and a dose-response curve was generated. The test was also performed in 3 healthy controls. Results Both prick-to-prick tests were negative. The result of the BAT was positive at all the concentrations tested in the patient's blood and negative in all the controls. Conclusions The BAT can help to clarify the agents implicated in an adverse reaction and can reduce the risk involved in diagnosis. The BAT can also prove useful in the study of reactions caused by low-molecular-weight antigens, for which routine diagnostic tests are not feasible.

show abstract

“…因此, 人们一直致力于研究的黄连素合成工艺 [12] , 期望获得一条简便、绿色、经济的合成路线. [13] , 后经霍夫曼重排得黄连素关键中间体 3,4-亚甲二氧基苯乙胺 [14] . [15] , 5,147.7,146.1,134.0,121.2,108.8,108.4,100.9,36.0,30.4; -).…”

Section: 黄连素还具有抗肿瘤unclassified