Anaphylactic reaction to isoflurane

Slegers-Karsmakers, S.; Stricker, Bruno H. Ch.

doi:10.1111/j.1365-2044.1988.tb06644.x

Cited by 19 publications

(6 citation statements)

References 1 publication

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“…[5][6][7] Isolated allergic reaction to halothane and isoflurane are documented in the literature. [8][9][10] In these cases, cutaneous manifestations consisted of raised erythematous and desquamative areas similar to those observed in our patient, with the same pattern of improvement after exposure was ceased.…”

Section: Discussionsupporting

confidence: 74%

Long‐term allergic dermatitis caused by sevoflurane: a clinical report

Herrerias

Navarro

Lujan

et al. 2014

Acta Anaesthesiol Scand

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Background: Allergy to volatile anaesthetics is extremely rare, but capable of damaging the professional career. Methods: This article presents the case of a 60-year-old surgeon who developed a skin rash on the reverse of hands, which progressively worsened and extended to distant fold areas. Blood tests were normal but for eosinophilia and risen total IgE, with normal specific globulins and skin prick tests for common allergens. After 8 years, a malfunction in the anaesthetic gas scavenging system was found, and symptoms remitted within a week following its replacement. Repeated open application test with sevoflurane led to the appearance of the same lesions in the tested areas and in distant body folds.

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Section: Discussionsupporting

confidence: 74%

Long‐term allergic dermatitis caused by sevoflurane: a clinical report

Herrerias

Navarro

Lujan

et al. 2014

Acta Anaesthesiol Scand

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“…Halothane has been considered responsible for occupational facial acneiform eruption in 2 physicians (2), and for urticaria/ angioedema syndrome in a patient who underwent general anaesthesia (3). A generalized erythematous rash, associated with bronchospasm and tachycardia, appeared within a few minutes of starting isoflurane (4). Interruption of the anaesthetic agent and antihistamine/ corticosteroid treatment quickly cleared the reaction, which did not reappear after halothane.…”

Section: Discussionmentioning

confidence: 99%

“…Isoflurane and other halogenated anaesthetic compounds can cause various undesirable effects, such as arterial hypertension, respiratory depression, cardiac arrhythmia, sialorrhoea and, more rarely, convulsions (1). Skin reactions are extremely uncommon (2)(3)(4).…”

mentioning

confidence: 99%

Isoflurane: an uncommon cause of occupational airborne contact dermatitis

et al. 1998

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“…Examples are anaphylaxis associated with glafenine [6][7][8][9][10][11], paracetamol [12][13][14], diclofenac [15][16][17], dextran and other blood volume expanders [18][19][20], ibuprofen [21], naproxen [22], cimetidine [23,24], ranitidine [25] and tolmetine [26][27][28][29][30]. The DSU published case reports or case series on anaphylaxis associated with glafenine [3,4,31], paracetamol [32], [33], polidocanol [34], cinoxacin [35], isoflurane [36], chlorhexidine [37], bromhexine [38] and ketoconazole [39].…”

Section: Discussionmentioning

confidence: 99%

Drug‐associated anaphylaxis: 20 years of reporting in the Netherlands (1974–1994) and review of the literature

Klauw

Wilson²,

Stricker

1996

Clin Experimental Allergy

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Summary Background Since 1963, the Drug Safety Unit of the Dutch Inspectorate for Health Care (DSU) holds a voluntary reporting system. Objective To analyse all reports received in the years 1974 to 1994, registered as anaphylaxis or as a diagnosis that could contain cases of anaphylaxis. Methods All reports were classified as probable or possible anaphylaxis according to previously described criteria and the causal relationship between exposure and anaphylaxis was assessed. Results Nine hundred and ninety‐two reports possibly concerning anaphylaxis were received between 1974 and 1994. Fifty‐six were unclassifiable. The remaining 936 reports concerned 326 men and 610 women. Three hundred and forty‐five reports were classified as anaphylaxis probable, 485 as anaphylaxis possible, and 106 as anaphylaxis unlikely by previously specified criteria. Drugs frequently associated with anaphylaxis (causal relationship certain or probable) were: glafenine (326 reports classified as anaphylaxis probable or possible), combination preparations with (propy)phenazone or propyphenazone/phenacetine (39), diclofenac (30), dextran (20), ibuprofen (14), floctafenine (12), allergen extracts (12), sulfamethoxazole with trimethoprim (12), and trimethoprim (11). There is probably substantial under‐reporting as well as reporting bias in these data. Furthermore, many reports were classified as possible and not as probable anaphylaxis because the temporal relationship was unknown or not reported. Conclusion Drugs that caused anaphylaxis most frequently were glafenine, NSAID and certain antibiotics. Data from a voluntary reporting system such as the DSU are valuable as an early warning system for drugs that may induce anaphylactic reactions.

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Anaphylactic reaction to isoflurane

Cited by 19 publications

References 1 publication

Long‐term allergic dermatitis caused by sevoflurane: a clinical report

Long‐term allergic dermatitis caused by sevoflurane: a clinical report

Isoflurane: an uncommon cause of occupational airborne contact dermatitis

Drug‐associated anaphylaxis: 20 years of reporting in the Netherlands (1974–1994) and review of the literature

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