Anandamide Induces Matrix Metalloproteinase-2 Production through Cannabinoid-1 Receptor and Transient Receptor Potential Vanilloid-1 in Human Dental Pulp Cells in Culture

Miyashita, Kazuyoshi; Oyama, Tohru; Sakuta, Tetsuya; Tokuda, Masanori; Torii, Mitsuo

doi:10.1016/j.joen.2012.02.025

Cited by 24 publications

(21 citation statements)

References 29 publications

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“…(ii) TRPV1 is co-localized with CB1 and CB2 in cerebromicrovascular endothelial cells [62] and with CB1 in endothelial cells from mesenteric arteries of cirrhotic rats [63,64]; (iii) TRPV1 is co-localized with both CB1 and CB2 in mouse bone-marrowderived dendritic cells [65], and in human skeletal muscle cells [66], myometrial smooth muscle cells [67], osteoclasts [68], proximal tubular (HK2) cells of the kidney [69], keratinocytes [70,71], melanocytes [72] and dental pulp cells [73]; (iv) TRPV1 is co-localized only with CB1 in human sperm cells [74], and only with CB2 in synoviocytes from rats after intraarticular injection of mono-iodo-acetate, a model of osteoarthritis [75]. In view of the previously reported cross-talk between TRPV1 and CB1 receptors at the level of down-stream signalling events [76,77], these many examples of co-expression between the channel and one or both cannabinoid receptor sub-types offer the opportunity of widening further the range of pharmacological effects that endogenous mediators capable of activating both types of receptors may have, and, hence, the extent of 'plasticity' that their action can produce in a large variety of biological systems.…”

Section: Co-expression Of Cb1 or Cb2 Receptors And Trpv1 Channels In mentioning

confidence: 99%

Why do cannabinoid receptors have more than one endogenous ligand?

Marzo

Petrocellis

2012

Phil. Trans. R. Soc. B

248

176

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The endocannabinoid system was revealed following the understanding of the mechanism of action of marijuana's major psychotropic principle, D 9-tetrahydrocannabinol, and includes two G-proteincoupled receptors (GPCRs; the cannabinoid CB1 and CB2 receptors), their endogenous ligands (the endocannabinoids, the best studied of which are anandamide and 2-arachidonoylglycerol (2-AG)), and the proteins that regulate the levels and activity of these receptors and ligands. However, other minor lipid metabolites different from, but chemically similar to, anandamide and 2-AG have also been suggested to act as endocannabinoids. Thus, unlike most other GPCRs, cannabinoid receptors appear to have more than one endogenous agonist, and it has been often wondered what could be the physiological meaning of this peculiarity. In 1999, it was proposed that anandamide might also activate other targets, and in particular the transient receptor potential of vanilloid type-1 (TRPV1) channels. Over the last decade, this interaction has been shown to occur both in peripheral tissues and brain, during both physiological and pathological conditions. TRPV1 channels can be activated also by another less abundant endocannabinoid, N-arachidonoyldopamine, but not by 2-AG, and have been proposed by some authors to act as ionotropic endocannabinoid receptors. This article will discuss the latest discoveries on this subject, and discuss, among others, how anandamide and 2-AG differential actions at TRPV1 and cannabinoid receptors contribute to making this signalling system a versatile tool available to organisms to fine-tune homeostasis.

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Section: Co-expression Of Cb1 or Cb2 Receptors And Trpv1 Channels In mentioning

confidence: 99%

Why do cannabinoid receptors have more than one endogenous ligand?

Marzo

Petrocellis

2012

Phil. Trans. R. Soc. B

248

176

View full text Add to dashboard Cite

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“…For example, SR141716 (also known as rimonabant) has been shown to act both as a CB1R antagonist and as an inverse agonist (Table 1) (15,72). Notably, endocannabinoids can also mediate some of their biological effects through alternative molecular targets such as the orphan G proteincoupled receptor GPR55 or the transient receptor potential cation channel (TRPV1) (90,127).…”

mentioning

confidence: 99%

Mitochondria: a possible nexus for the regulation of energy homeostasis by the endocannabinoid system?

Lipina

Irving

Hundal

2014

American Journal of Physiology-Endocrinology and Metabolism

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“…CB1 is also reportedly expressed in human odontoblasts (Que et al, 2017). It can accelerate the formation of "reparative dentin" in rat odontoblasts by modulating extracellular Ca 2+ entry (Tsumura et al, 2012) and may be involved in dental pulp tissue repair by regulating matrix metalloproteinase-2 in dental pulp cells (Miyashita, Oyama, Sakuta, Tokuda, & Torii, 2012). The role of cannabinoid regulation of pulp pain and dentin repair/regeneration needs further investigation.…”

Section: Pulp Tissuementioning

confidence: 99%

The effects of cannabis use on oral health

Liu

Yang

et al. 2019

Oral Diseases

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Cannabis, also known as marijuana, is one of the most commonly used substances for medical and recreational purposes globally. With the trend of global legalization of medical use of cannabis and even the recreational use, the prevalence of recreational use of cannabis has increased markedly over the past few years. Correspondingly, the potential health concerns related to cannabis consumption have also increased. Therefore, it is necessary for oral healthcare providers to understand the effects of cannabis use on oral health. This review briefly summarizes the components of cannabis, biologic activities on tissues, and mechanisms of action in human cells and tissues. Oral tissue expression of cannabinoid receptors and the potential association of cannabis to oral diseases are also examined. The goals of this review are to (1) elaborate the basic biology and physiology of cannabis in human oral tissues, and (2) provide a better understanding the effects of its use and abuse on oral health. Due to insufficient information, more well‐designed studies should be conducted. It is urgent to include cannabis usage into dental patient health records.

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Anandamide Induces Matrix Metalloproteinase-2 Production through Cannabinoid-1 Receptor and Transient Receptor Potential Vanilloid-1 in Human Dental Pulp Cells in Culture

Cited by 24 publications

References 29 publications

Why do cannabinoid receptors have more than one endogenous ligand?

Why do cannabinoid receptors have more than one endogenous ligand?

Mitochondria: a possible nexus for the regulation of energy homeostasis by the endocannabinoid system?

The effects of cannabis use on oral health

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