Analyzing the resting state functional connectivity in the human language system using near infrared spectroscopy

Molavi, Behnam; May, Lillian; Gervain, Judit; Carreiras, Manuel; Werker, Janet F.; Dumont, Guy A.

doi:10.3389/fnhum.2013.00921

Cited by 36 publications

(33 citation statements)

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“…Using NIRS, Bortfeld, Fava, and Boas (2009) have shown greater hemodynamic activation in left temporal regions to an audio-visual presentation as opposed to visual only in 21 infants aged 6-9 months. Molavi et al (2013) found a left-lateralised response to language in 19 newborn infants, and Peña et al (2003) observed greater activation in left temporal areas in 12 newborns, 2-5 days post-birth, when exposed to normal speech compared to backward speech or silence, suggesting a lateralised response is already present at birth. FMRI data generally support these observations, showing that in 2-day-old newborns, language activation to speech is less lateralised compared to adults (Perani et al, 2011), but a left hemisphere advantage to speech over music is found in slightly older infants (Dehaene-Lambertz et al, 2010).…”

Section: Introductionmentioning

confidence: 92%

Variability in lateralised blood flow response to language is associated with language development in children aged 1–5 years

et al. 2015

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The developmental trajectory of language lateralisation over the preschool years is unclear. We explored the relationship between lateralisation of cerebral blood flow velocity response to object naming and cognitive performance in children aged 1-5 years. Functional transcranial Doppler ultrasound was used to record blood flow velocity bilaterally from middle cerebral arteries during a naming task in 58 children (59% male). At group level, the Lateralisation Index (LI) revealed a greater relative increase in cerebral blood flow velocity within the left as compared to right middle cerebral artery. After controlling for maternal IQ, left-lateralised children displayed lower expressive language scores compared to right- and bi-lateralised children, and reduced variability in LI. Supporting this, greater variability in lateralised response, rather than mean response, was indicative of greater expressive language ability. Findings suggest that a delayed establishment of language specialisation is associated with better language ability in the preschool years.

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Section: Introductionmentioning

confidence: 92%

Variability in lateralised blood flow response to language is associated with language development in children aged 1–5 years

et al. 2015

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“…[34][35][36][37] Brain mapping with fcMRI and fcNIRS has shown good spatial correlations, 38,39 and good test-retest reliability has been reported with fcNIRS. 40 The higher temporal resolution of NIRS (∼1 ms) as compared to fMRI (seconds) 41 may prevent confounding of physiological noise, such as respiratory and cardiovascular activity, with intrinsic activity.…”

Section: Introductionmentioning

confidence: 99%

Language mapping in children using resting-state functional connectivity: comparison with a task-based approach

Gallagher¹,

Tremblay²,

Vannasing³

2016

J. Biomed. Opt

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Abstract. Patients with brain tumor or refractory epilepsy may be candidates for neurosurgery. Presurgical evaluation often includes language investigation to prevent or reduce the risk of postsurgical language deficits. Current techniques involve significant limitations with pediatric populations. Recently, near-infrared spectroscopy (NIRS) has been shown to be a valuable neuroimaging technique for language localization in children. However, it typically requires the child to perform a task (task-based NIRS), which may constitute a significant limitation. Resting-state functional connectivity NIRS (fcNIRS) is an approach that can be used to identify language networks at rest. This study aims to assess the utility of fcNIRS in children by comparing fcNIRS to more conventional task-based NIRS for language mapping in 33 healthy participants: 25 children (ages 3 to 16) and 8 adults. Data were acquired at rest and during a language task. Results show very good concordance between both approaches for language localization (Dice similarity coefficient ¼ 0.81 AE 0.13) and hemispheric language dominance (kappa ¼ 0.86, p < 0.006). The fcNIRS technique may be a valuable tool for language mapping in clinical populations, including children and patients with cognitive and behavioral impairments. © The Authors.Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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“…Previous studies have shown that frontal and temporal regions of the language network appear anatomically connected already in the first postnatal weeks (41)(42)(43). Moreover, these regions show time-lagged cross-correlations in response to passive listening to speech stimuli (44) and exhibit phase synchronization particularly in the left hemisphere (45). Our study aimed to provide a characterization of the spatiotemporal dynamics within this network during memory assessments by exploring the different configurations as a function of the familiarity of a given speech stimulus-namely, when the system processes a word that is familiar to the newborn versus a totally novel word.…”

Section: Significancementioning

confidence: 99%

Brain regions and functional interactions supporting early word recognition in the face of input variability

Benavides-Varela

Šiugždaitė

Gómez

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

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Perception and cognition in infants have been traditionally investigated using habituation paradigms, assuming that babies' memories in laboratory contexts are best constructed after numerous repetitions of the very same stimulus in the absence of interference. A crucial, yet open, question regards how babies deal with stimuli experienced in a fashion similar to everyday learning situationsnamely, in the presence of interfering stimuli. To address this question, we used functional near-infrared spectroscopy to test 40 healthy newborns on their ability to encode words presented in concomitance with other words. The results evidenced a habituation-like hemodynamic response during encoding in the left-frontal region, which was associated with a progressive decrement of the functional connections between this region and the left-temporal, right-temporal, and right-parietal regions. In a recognition test phase, a characteristic neural signature of recognition recruited first the right-frontal region and subsequently the right-parietal ones. Connections originating from the right-temporal regions to these areas emerged when newborns listened to the familiar word in the test phase. These findings suggest a neural specialization at birth characterized by the lateralization of memory functions: the interplay between temporal and left-frontal regions during encoding and between temporo-parietal and right-frontal regions during recognition of speech sounds. Most critically, the results show that newborns are capable of retaining the sound of specific words despite hearing other stimuli during encoding. Thus, habituation designs that include various items may be as effective for studying early memory as repeated presentation of a single word.newborns | language | habituation | memory | fNIRS effective connectivity H abituation, namely the decreased response to repeated presentations of stimuli, has been widely used to investigate infant cognition. Both behavioral (1) and neuroimaging (2, 3) habituation paradigms are regularly implemented for assessing a wide range of mental processes including categorization, object representation, and memory in very young babies. Despite this long tradition, it remains elusive the extent to which the results of habituation studies (which often consist of massive repetition of a single stimulus) can inform our understanding of memory functions in everyday-like situations-that is, in the presence of various stimuli.Developmental studies in the language domain have uncovered basic perceptual (4-6), discrimination (7,8), and mnemonic capacities (9-14) in newborns and fetuses, supporting the hypothesis that memories for sounds begin to be established very early in life. However, infants' memory for specific words seems to be highly vulnerable to interference. Newborns are capable of remembering a single word that they have heard in a classic habituation paradigm (i.e., consecutive/massed repetitions) and after a silent pause but readily forget the word if interfering words are introduced in the...

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Analyzing the resting state functional connectivity in the human language system using near infrared spectroscopy

Cited by 36 publications

References 36 publications

Variability in lateralised blood flow response to language is associated with language development in children aged 1–5 years

Variability in lateralised blood flow response to language is associated with language development in children aged 1–5 years

Language mapping in children using resting-state functional connectivity: comparison with a task-based approach

Brain regions and functional interactions supporting early word recognition in the face of input variability

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