Green roofs (roofs with a vegetated surface and substrate) provide ecosystem services in urban areas, including improved storm-water management, better regulation of building temperatures, reduced urban heat-island effects, and increased urban wildlife habitat. This article reviews the evidence for these benefits and examines the biotic and abiotic components that contribute to overall ecosystem services. We emphasize the potential for improving green-roof function by understanding the interactions between its ecosystem elements, especially the relationships among growing media, soil biota, and vegetation, and the interactions between community structure and ecosystem functioning. Further research into green-roof technology should assess the efficacy of green roofs compared to other technologies with similar ends, and ultimately focus on estimates of aggregate benefits at landscape scales and on more holistic cost-benefit analyses.

Building facades are under permanent environmental influences, such as sun and acid rain, which age and can ultimately destroy them. Living wall systems can protect facades and offer similar benefits to those gained from installing a green roof. A view back in history shows that vegetated facades are not new technology but can offer multiple benefits as a component of current urban design. In the 19th century, in many European and some North American cities, woody climbers were frequently used as a cover for simple facades. In Central Europe in the 1980s a growing interest in environmental issues resulted in the vision to bring nature into cities. In many German cities incentive programmes were developed, including some that supported tenant initiatives for planting and maintaining climbers in their backyards and facades. Since the 1980s, research has been conducted on issues such as the insulating effects of plants on facades, the ability of plants to mitigate dust, plants' evaporative cooling effects, and habitat creation for urban wildlife, including birds, spiders and beetles. The aim of this paper is to review research activities on the green wall and facade technology with a focus on Germany. The potential of green facades to improve urban microclimate and buildings' ecological footprint is high, but they have not developed a widespread presence outside of Germany because they are not as well known as green roofs and there is a lack of implementation guidelines and incentive programs in other countries.

Flavonoids represent a potential source of new antitrypanosomatidic leads. Starting from a library of natural products, we combined target-based screening on pteridine reductase 1 with phenotypic screening on Trypanosoma brucei for hit identification. Flavonols were identified as hits, and a library of 16 derivatives was synthesized. Twelve compounds showed EC50 values against T. brucei below 10 μM. Four X-ray crystal structures and docking studies explained the observed structure-activity relationships. Compound 2 (3,6-dihydroxy-2-(3-hydroxyphenyl)-4H-chromen-4-one) was selected for pharmacokinetic studies. Encapsulation of compound 2 in PLGA nanoparticles or cyclodextrins resulted in lower in vitro toxicity when compared to the free compound. Combination studies with methotrexate revealed that compound 13 (3-hydroxy-6-methoxy-2-(4-methoxyphenyl)-4H-chromen-4-one) has the highest synergistic effect at concentration of 1.3 μM, 11.7-fold dose reduction index and no toxicity toward host cells. Our results provide the basis for further chemical modifications aimed at identifying novel antitrypanosomatidic agents showing higher potency toward PTR1 and increased metabolic stability.

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Medicine and healthcare are undergoing profound changes. Whole-genome sequencing and high-resolution imaging technologies are key drivers of this rapid and crucial transformation. Technological innovation combined with automation and miniaturization has triggered an explosion in data production that will soon reach exabyte proportions. How are we going to deal with this exponential increase in data production? The potential of “big data” for improving health is enormous but, at the same time, we face a wide range of challenges to overcome urgently. Europe is very proud of its cultural diversity; however, exploitation of the data made available through advances in genomic medicine, imaging, and a wide range of mobile health applications or connected devices is hampered by numerous historical, technical, legal, and political barriers. European health systems and databases are diverse and fragmented. There is a lack of harmonization of data formats, processing, analysis, and data transfer, which leads to incompatibilities and lost opportunities. Legal frameworks for data sharing are evolving. Clinicians, researchers, and citizens need improved methods, tools, and training to generate, analyze, and query data effectively. Addressing these barriers will contribute to creating the European Single Market for health, which will improve health and healthcare for all Europeans.

BackgroundSleep Disordered Breathing (SDB) is a common childhood disorder that encompasses a range of sleep-related upper airway obstruction. Children with SDB demonstrate significant neurocognitive deficits. Adenotonsillectomy is the first line of treatment for SDB and whilst this improves respiratory disturbance, it remains to be established whether neurocognitive gains also result.MethodsA total of 44 healthy snoring children aged 3–12 years awaiting adenotonsillectomy (SDB group), and 48 age and gender matched non-snoring controls from the general community, completed the study. All children underwent polysomnography and neurocognitive assessment at baseline and after a 6-month follow-up (after surgery in the snoring group). Our primary aim was to determine whether neurocognitive deficits in snoring children were significantly improved following adenotonsillectomy.ResultsWide ranging neurocognitive deficits were found at baseline in SDB children compared to controls, most notably a 10 point IQ difference (P<.001) and similar deficits in language and executive function. Whilst adenotonsillectomy improved respiratory parameters and snoring frequency at 6 months post surgery, neurocognitive performance did not improve relative to controls.ConclusionAdenotonsillectomy successfully treated the respiratory effects of SDB in children. However, neurocognitive deficits did not improve 6-months post-operatively.

Basal sleep spindle activity is associated with different aspects of cognitive performance in children. To the extent that these associations in a pediatric population are different from what is known in adult sleep may play an important role in development.

Background/Aim: The contribution of cerebrovascular dysfunction to the manifestation of dementia and cognitive decline in late life is gaining increased attention. We aimed to systematically review evidence for associations between dementia or aging and cerebrovascular function as measured using transcranial Doppler (TCD) examination. Methods: A total of 1,172 articles were retrieved from PsychInfo and PubMed searches, and 34 relevant articles were identified using a variety of TCD methods. Results: The pulsatility index (vessel resistance), spontaneous emboli and cerebrovascular reactivity to hyper-/hypocapnia appeared good discriminators of dementia. Aging was associated with a slowing in blood flow velocity. Conclusion: TCD ultrasonography is inexpensive, portable and well tolerated by aged and demented subjects. The technique stands to make a valuable contribution to the knowledge regarding the underlying functional biology of age-related cognitive change and dementia.