Analyzing Association of theXRCC3Gene Polymorphism with Ovarian Cancer Risk

Abstract

This meta-analysis aims to examine whether the XRCC3 polymorphisms are associated with ovarian cancer risk. Eligible case-control studies were identified through search in PubMed. Pooled odds ratios (ORs) were appropriately derived from fixed effects models. We therefore performed a meta-analysis of 5,302 ovarian cancer cases and 8,075 controls from 4 published articles and 8 case-control studies for 3 SNPs of XRCC3. No statistically significant associations between XRCC3 rs861539 polymorphisms and ovarian cancer risk were observed in any genetic models. For XRCC3 rs1799794 polymorphisms, we observed a statistically significant correlation with ovarian cancer risk using the homozygote comparison (T2T2 versus T1T1: OR = 0.70, 95% CI = 0.54–0.90, P = 0.005), heterozygote comparison (T1T2 versus T1T1: OR = 1.10, 95% CI = 1.00–1.21, P = 0.04), and the recessive genetic model (T2T2 versus T1T1+T1T2: OR = 0.67, 95% CI = 0.52–0.87, P = 0.002). For XRCC3 rs1799796 polymorphisms, we also observed a statistically significant correlation with ovarian cancer risk using the heterozygote comparison (T1T2 versus T1T1: OR = 0.91, 95% CI = 0.83–0.99, P = 0.04). In conclusion, this meta-analysis shows that the XRCC3 were associated with ovarian cancer risk overall for Caucasians. Asian and African populations should be further studied.

Haplotype Based Analysis of XRCC3 Gene Polymorphisms in Thyroid Cancer

“…X-ray repair complementing defective repair in Chinese hamster cells 3 ( XRCC3 ) belongs to a family of genes responsible for repairing DNA double strand breaks caused by normal metabolic processes or exposure to ionizing radiation [20]. XRCC3 proteins are recruited to a DSB during the S and G2/M phase of the cell cycle.…”

“…In earlier studies, rs1799794 has been observed associated with increased risk of overall cancer [50], breast cancer [23], bladder cancer [51, 52]. Nevertheless, decreased risk of ovarian cancer has also been observed in some of the studies [20]. …”

“…The SNP rs1799794 (4541 A > G ) is located in 5ˊUTR and the SNP rs1799796 (17893 A > G ) is located in exon 5 splice site [19]. Previous studies have examined the relationship between different XRCC3 polymorphisms with the risk of different cancers such as lung cancer, breast cancer, ovarian cancer and head and neck cancer [20-25]. The association between XRCC3 polymorphisms and thyroid cancer risk has not been studied in Pakistani population however, published studies in other populations remain confusing and focussed on single variant rather than haplotype-based gene-gene interaction analysis.…”

Lack of Association between the 4234G/C X-Ray Repair Cross- Complementing 2 ( XRCC2 ) Gene Polymorphism and the Risk of Endometrial Cancer among Polish Population

“…The double-strand break DNA repair pathway, including XRCC2 gene, is implicated in maintaining genomic stability and therefore could affect cancer risk. Common genetic polymorphisms in DNA repair genes might affect protein function and thus the capacity of repair DNA damage, which in turn could lead to genetic instability [1,2].…”

Association between the rs11614913 variant of miRNA-196a-2 and the risk of epithelial ovarian cancer

“…In addition, Eitan et al (10) identified miR-200a, miR-34a, and miR-449b as the most downregulated miRNAs in advanced Association between the rs11614913 variant of miRNA-196a-2 and the risk of epithelial ovarian cancer (11) reported the association of high levels of miR-196a expression and worse overall survival in ovarian cancer patients, especially in advanced stage tumors. Single nucleotide polymorphisms (SNPs) have also been examined as potential EOC risk indictors (12)(13)(14). However, the mechanism and genetic factors involved in the progression of this cancer remain to be elucidated.…”