Analytical techniques in pharmaceutical analysis: A review

Siddiqui, Masoom Raza; ALOthman, Zeid A.; Rahman, Nafisur

doi:10.1016/j.arabjc.2013.04.016

Cited by 548 publications

(251 citation statements)

References 174 publications

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“…From the commencement of official pharmaceutical analysis, analytical assay methods were included in the compendial monographs with the aim to characterize the quality of bulk drug materials by setting limits of their active ingredient content. In recent years, the assay methods in the monographs include titrimetric, spectrometry, chromatography, and capillary electrophoresis; also the electro analytical methods can be seen in the literature 1 . Spectroscopy is a most powerful tool available for the study of atomic and molecular structure/s and is used in the analysis of wide range of samples.…”

Section: Introductionmentioning

confidence: 99%

Validated Derivative Spectrophotometric Methods for the Analysis of Lincomycin in Bulk and Dosage Forms

2017

JCBSC

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Section: Introductionmentioning

confidence: 99%

Validated Derivative Spectrophotometric Methods for the Analysis of Lincomycin in Bulk and Dosage Forms

2017

JCBSC

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“…The electrochemical sensors have special properties of electrode surface area due to the large surface area to facilitate improving sensitivity, selectivity and reproducibility of the biological substances determination. At the same time, electrochemical methods of biological substances determination on the surface electrode based on metal nanoparticles are essentially simpler and cheaper, than most of other methods such as optical and chromatographic techniques, used in biochemistry, molecular biology, and medical diagnostics [12][13][14]. Despite a wide range of materials used as mediator, the use of platinum group metals and silver are preferable.…”

Section: Introductionmentioning

confidence: 99%

Influence of silver nanoparticles conditions synthesis on their electrochemical properties

Перевезенцева¹,

Gorchakov²,

Petrushin³

et al. 2016

AIP Conference Proceedings

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Influence of stabilizing agent and synthesis temperature on the optical properties of silver nanoparticles as active materials in surface plasmon resonance (SPR) vbimatov@mail.ru Abstract. The shape, size, optical properties and electrochemical activity of silver nanoparticles (AgNPs) obtained by chemical reduction methods depending on the preparation conditions were investigated. Silver sols consist of AgNPs of different shapes. They are as follows spherical -30 nm, polyhedral -35 nm, 50 nm nanorods. It was shown that the position of the absorption spectrum peak in AgNPs depend on the molar ratio of mixture AgNO 3 :Na 3 C 6 H 5 O 7 . The maximum of the absorption spectrum peak of AgNPs is shifted by 10 nm to longer wavelengths area in presence excess of a reducing agent or the increasing of boiling time. After storage for one week the spectrum intensity of AgNPs obtained in the mixture AgNO 3 :Na 3 C 6 H 5 O 7 = 1:1 is increased in comparison with freshly prepared AgNPs, which is caused by the increase of AgNPs quantity of a given size. The AgNPS obtained in the mixture AgNO 3 :Na 3 C 6 H 5 O 7 = 1:3 have the most electrochemical activity. The conditions that the AgNPs have the most electrochemical activity were found.

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“…[2][3][4][5][6][7] The growing pharmaceutical interest in these techniques is probably a direct consequence of their major advantage over other analytical techniques, namely, an easy sample preparation without any pretreatments. 8 In addition, the quality of a pharmaceutical formulation is a direct consequence of the quality of the raw materials used in its making. Scanning electron microscopy (SEM) and transmission electron microscopy have been used to obtain physicochemical characteristics, such as particle size and crystalline form, which have a significant influence on the dissolution rate and bioavailability of a pharmaceutical formulation.…”

Section: Introductionmentioning

confidence: 99%

Fourier Transform Infrared Spectroscopy, Thermogravimetric Analysis, Scanning Electron Microscopy as Supporting Tools in Quality Control of Antiparasitics

Silva¹,

Gonring²,

Silva³

et al. 2017

Quim. Nova

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publicado na web em 11/12/2017 This study shows that Fourier transform infrared (FTIR) spectroscopy, thermogravimetric analysis (TGA), and scanning electron microscopy (SEM) can be used as supporting tools for the evaluation of the quality of antiparasitics. In addition, an analytical methodology was developed and validated to quantify simultaneously thiabendazole (TB), febantel (FB), toltrazuril (TZ), and fluazuron (FZ) in bulk and in their veterinary pharmaceutical formulations using reverse phase high performance liquid chromatography (RP-HPLC). In order to investigate stability, pharmaceuticals were submitted to degradation processes under different conditions, such as recommended by the International Conference on Harmonization. The chromatographic conditions were optimized and the validation parameters, such as selectivity, linearity, detection limit, quantification limit, precision, accuracy, and robustness showed results within acceptable standards. All analytes were stable in the stability assays in acid and basic media and thermal conditions, except in the oxidation process, which presented two degradation peaks. Physicochemical characterization by TGA, FTIR, and SEM of raw materials of TB, FB, TZ, and FZ provided information about the authenticity of the analytes, proving the wide applicability of the instrumental techniques. The RP-HPLC proposed method was found to be accurate, precise, and reproducible and can in addition be used for routine quality control analysis.

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Analytical techniques in pharmaceutical analysis: A review

Cited by 548 publications

References 174 publications

Validated Derivative Spectrophotometric Methods for the Analysis of Lincomycin in Bulk and Dosage Forms

Validated Derivative Spectrophotometric Methods for the Analysis of Lincomycin in Bulk and Dosage Forms

Influence of silver nanoparticles conditions synthesis on their electrochemical properties

Fourier Transform Infrared Spectroscopy, Thermogravimetric Analysis, Scanning Electron Microscopy as Supporting Tools in Quality Control of Antiparasitics

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