Analytical techniques for the determination of acetaminophen: A review

Montaseri, Hanieh; Forbes, Patricia B.C.

doi:10.1016/j.trac.2018.08.023

Cited by 79 publications

(37 citation statements)

References 92 publications

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“…However, poor electrochemical responses of ACTM at bare working electrodes are remarkably considered as the limitation of such electrochemical sensing techniques. One strategy to improve the signal is to modify the electrodes with various functional materials including noble metal nanoparticles (NPs) [15,16], metal oxides [17,18], polymers [19,20], carbon materials [21,22], natural enzyme [23]. Among these materials, graphene (including reduced graphene oxide or RGO) and metal NPs have been subjected to intense research studies due to their unique structures and intrinsic properties.…”

Section: Introductionmentioning

confidence: 99%

Cauliflower‐like Platinum Particles Decorated Reduced Graphene Oxide for Sensitive Determination of Acetaminophen

et al. 2019

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Over the past years, the development of electrochemical sensing platforms for the sensitive detection of drug molecules have received great interests. In this research study, we introduced cauliflower‐like platinum particles decorated reduced graphene oxide modified glassy carbon electrode (Pt−RGO/GCE) as an electrochemical sensing platform for highly sensitive determination of acetaminophen (ACTM). The sensor was prepared via a simple and environmentally friendly two‐step electrodeposition method at room temperature. The combination of conductive RGO nanosheets and unique structured Pt particles (average 232 nm in diameter) provided an efficient interface with large effective surface area which greatly facilitated the electron transfer of ACTM. The experimental conditions that might affect the drug detection were studied in detail and optimized for best performance. The Pt−RGO/GCE was able to detect ACTM up to the limit of 2.2 nM with a linear concentration range from 0.01 to 350 μM. With its high reproducibility, excellent stability and selectivity, the as‐fabricated sensor was successfully applied to the ACTM content measurement in commercial tablets.

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Section: Introductionmentioning

confidence: 99%

Cauliflower‐like Platinum Particles Decorated Reduced Graphene Oxide for Sensitive Determination of Acetaminophen

et al. 2019

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“…A variety of analytical methods based on electrochemical, spectroscopic, and chromatographic techniques have been reported in literature for determination of APAP mainly in pharmaceutical formulations and biological fluids [5,6]. However, most of the analytical methods used liquid–liquid extraction (LLE) of SPE for analysis of APAP; which are time consuming and employs laborious extraction procedures and are greatly discouraged due to consumption of large volume of toxic organic solvents.…”

Section: Introductionmentioning

confidence: 99%

Simple and rapid analysis of acetaminophen in human autopsy samples by vortex‐assisted dispersive liquid–liquid microextraction‐thin layer chromatography‐image analysis

Jain

Kumari

2020

Separation Science Plus

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In the present work, we describe a simple, rapid, cost‐effective, environmentally friendly and high‐sample‐throughput analytical method based on coupling vortex‐assisted dispersive liquid–liquid microextraction with thin layer chromatography analysis for quantitative determination of acetaminophen in whole human blood and tissues of stomach and liver. Followed by dispersive liquid–liquid microextraction, 20 μL of sedimented phase (chloroform) was spotted on a thin layer chromatography plate and developed with mobile phase of chloroform: acetone (8:2, v/v). The developed plate was photographed under ultraviolet chamber at 254 nm and the image was processed for quantification of spots using freely available ImageJ software. Under the optimized conditions, the limit of detection and limit of quantification were found to be in the range of 7.74–8.33 and 23.4–25.2 μg/spot, respectively. The method was found to be linear in the range of 30–300 μg/spot with a coefficient of determination of 0.996 and 0.998 in blood and tissue, respectively. The developed method has been successfully applied for the determination of acetaminophen in autopsy samples from a case of acetaminophen overdose. The method does not require any sophisticated high‐end instrumentation and can be routinely applied for determination of acetaminophen in complex biological samples in resource‐limited laboratories.

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“…Many methods were proposed for paracetamol determination in pharmaceuticals and biological fluids , including UV−Vis spectrometry , spectrofluorimetry , IR spectroscopy , liquid chromatography and flow injection analysis (FIA) with spectrophotometric and chemiluminescence detection . A lot of attention was paid to determination of paracetamol in the presence of caffeine, ascorbic and acetylsalicylic acid, ibuprofen and pseudoephedrine by means of FIA with amperometric detection , derivative and chemometric aided spectrophotometry , sequential injection chromatography and differential pulse voltammetry (DPV) with the GCE .…”

Section: Introductionmentioning

confidence: 99%

The Mn‐zeolite/Graphite Modified Glassy Carbon Electrode: Fabrication, Characterization and Analytical Applications

2020

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In this work, low‐cost and environmentally friendly natural zeolite exchanged with Mn2+ cations was used for the first time to modify the glassy carbon electrode with the aim to obtain a fast and simple sensor for voltammetric determination of paracetamol (PAR). The Mn‐zeolite/graphite modified glassy carbon electrode (MnZG−GCE) was prepared by evaporation of solvent from dispersion of the zeolite/graphite mixture with the polymer in acetone. The electrochemical characteristics of MnZG−GCE were conducted by electrochemical impedance spectroscopy and cyclic voltammetry. Compared with graphite modified GCE (G−GCE), MnZG−GCE exhibited better electrochemical parameters, which confirms the superiority of applying zeolite in the proposed sensor. The optimization of the pH‐value of supporting electrolyte and instrumental parameters were carried out. The peak current was proportional to the concentration of PAR in a phosphate buffer saline of pH 6.0 in the range from 0.029 to 0.69 mg L−1 (R=0.9997) with limit of detection of 8.8 μg L−1. Finally, the proposed electrode was successfully applied to determine the paracetamol in pharmaceutical formulation and certified reference materials. The satisfactory recoveries, which ranged from 89.2 to 102.7 %, were obtained for all studied samples. It confirmed the attractiveness of relatively inexpensive, easy to fabricate and non‐toxic MnZG−GCE in determination of PAR in complicated matrixes.

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Analytical techniques for the determination of acetaminophen: A review

Cited by 79 publications

References 92 publications

Cauliflower‐like Platinum Particles Decorated Reduced Graphene Oxide for Sensitive Determination of Acetaminophen

Cauliflower‐like Platinum Particles Decorated Reduced Graphene Oxide for Sensitive Determination of Acetaminophen

Simple and rapid analysis of acetaminophen in human autopsy samples by vortex‐assisted dispersive liquid–liquid microextraction‐thin layer chromatography‐image analysis

The Mn‐zeolite/Graphite Modified Glassy Carbon Electrode: Fabrication, Characterization and Analytical Applications

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