Analytical strategy for detecting doping agents in hair

Thieme, Detlef; Grosse, Joachim; Sachs, Hans; Mueller, Robert

doi:10.1016/s0379-0738(99)00177-2

Cited by 66 publications

(40 citation statements)

References 15 publications

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“…Bununla birlikte, testosteron belirlenmesinde tanımlayıcı olarak; saçta testosteron esterlerinin bulunması, doping yüklemesiyle mümkün olabilmektedir çünkü esterler şüphesiz ekzojen maddelerdir. 60,61 Saç analizinin diğer bir avantajı ise aynı üriner metabolit (norandrosteron and noretiokholanolon) oluşmasına sebep olan nandrolon ve diğer 19-norsteroidlerin (norandrostenedion ve norandrostenediol) kötüye kullanımının ayırt edilebilmesine imkân sağlamasıdır. 62 Bu durum idrarda açık olarak mümkün değil iken, saçta esas maddenin ana yapısının tanımlanması mümkündür.…”

Section: Dopi̇ng Uygulamalarinin Doğrulanmasiunclassified

Incorporation of Drug and Substances in Hair

Mutlu¹,

Aşıcıoğlu²

2018

Turkiye Klinikleri J Foren Sci Leg Med

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aç, homojen bir yapıya sahip gibi görünse de aslında oldukça karmaşık olan biyolojisi kısmen anlaşılmıştır.1 Memelilerde saç; protein (%65-95), su (%15-35), lipit (%1-9) ve minerallerden (<%1) oluşan deri eklerinden biridir. Saç şaftında korteksi çevreleyen bir kütikül bulunduğu gibi, bazı saç tiplerinde santral medullayı çevreleyen ilave bir kütikülde bulunmaktadır.2 Saç apokrin, sebase ve ter bezleriyle yakın ilişkide olan cildin A An na ah h t ta ar r K Ke e l li i m me e l le er r: : Saç; ilaç; birikim; kötüye kullanım A AB BS S T TR RA AC CT T In recent years hair has become a fundamental biological specimen, alternative to the usual samples blood and urine, for drug testing in the fields of forensic toxicology, clinical toxicology and clinical chemistry. Analytical results of drugs of abuse in hair provide useful information on chronic drug use. They are valuable to presume the history and severity of individual drug abuse and to provide supplementary information on drug use to facilitate interpretation of urine drug analysis. Hair testing has larger detection window. The sample collection is non-invasive. Another advantage of hair samples is that it can be stored at room temperature and do not need to be analyzed quickly after they are collected. Hair analysis is also used for detection of gestational drug exposure, doping control and detection of alcohol abuse. It has been reported that drugs are incorporated into hair by binding to such intracellular components as melanins, lipids, and proteins. It has been proposed that drugs and substances can enter into hair during at least 3 stages: from the blood during hair formation, from sweat and sebum, and from external environment. The aim of this review is to document and discuss the mechanisms of drug or substance accumulation in hair and its influencing factors, application of hair analysis.

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Section: Dopi̇ng Uygulamalarinin Doğrulanmasiunclassified

Incorporation of Drug and Substances in Hair

Mutlu¹,

Aşıcıoğlu²

2018

Turkiye Klinikleri J Foren Sci Leg Med

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“…Once incorporated into hair, a single dose of cocaine can be detected for 2 to 6 months. Codeine was detected in hair for 8 weeks after a single oral dose of 60 mg (Thieme et al, 2000).…”

Section: Metabotypes Based On Occurrences Of Metabolitesmentioning

confidence: 99%

Metabotype Concept: Flexibility, Usefulness and Meaning in Different Biological Populations

Semmar¹

2012

Metabolomics

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“…Les travaux les plus récents ont essentiellement portés sur la caractérisation des anabolisants (15)(16)(17)(18)(19)(20)(21)(22)(23)(24), des B-adrénergiques (25-28), des dérivés de l'éphedri-ne (29) et des corticostéroïdes (30,31). Toutes les procédures font appel à la spectrométrie de masse, avec filtrage par simple ou triple quadripole, ou encore par haute résolution.…”

Section: Prélèvement Et Analyseunclassified

“…Gleixner et al (26), en 1996, ont identifié du clenbuterol chez 2 culturistes. Thieme et al (17,18) ont analysé les cheveux d'un culturiste décédé d'un infarctus à 32 ans pour identifier plusieurs esters de testosterone, de la nandrolone décanoate, de la metenolone et de la metandienone. Kintz et al (24) ont retrouvé de la nandrolone, de la testosterone et du stanozolol dans les cheveux de 2 culturistes, accusés de trafic international.…”

Section: Applicationsunclassified

Quelle place pour les cheveux dans la lutte contre le dopage ?

Kintz¹

2000

Ann Toxicol Anal

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Analytical strategy for detecting doping agents in hair

Cited by 66 publications

References 15 publications

Incorporation of Drug and Substances in Hair

Incorporation of Drug and Substances in Hair

Metabotype Concept: Flexibility, Usefulness and Meaning in Different Biological Populations

Quelle place pour les cheveux dans la lutte contre le dopage ?

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