Analytical procedure for mapping the distribution of 10B and 99Tc markers in cryo-sections of animal tissue samples by secondary ion mass spectrometry

Microdistribution and quantification of the boron neutron capture therapy drug BPA in primary cell cultures of human glioblastoma tumour by NanoSIMS

“…Normalising two ions acquired simultaneously accounts for different image sizes and minimises the effect of primary ion beam current variations, total sputter yield and ion transmission, between different ROIs and images acquired across different NanoSIMS sessions. The 10 B -/ 12 Cratio in SIMS analysis has previously been shown to correlate linearly with the bulk B concentration in BPA-doped (0-800 ppm) mouse brain tissue as determined by ICP-MS. 59 The normalised 10 Band 10 B 12 Csecondary ion intensity values from nuclei and cytoplasm of each sample are presented separately in box plots…”

Quantitative secondary ion mass spectrometric analysis of secondary ion polarity in GaN films implanted with oxygen

“…For a comparison of depth profiles (depth resolution and background concentration of O ions in the sample chamber during the analysis), a GaN film implanted with 16 O + ions at a dose of 5 × 10 15 ions=cm 2 was analyzed by two methods with different shaped primary ion beams: a raster-scanned focused ion beam (RS beam) 11,12) and a broad ion beam with an oval shape (BS beam). [13][14][15] The density of the primary ion beam is approxi- mately the same in both the RS beam (0.0013 nA=µm 2 ) and the BS beam (0.0012 nA=µm 2 ). SIMS analyses were conducted with different primary ion beam irradiation methods to determine their effectiveness for depth profiling.…”

“…Depth profiling using SIMS is typically performed using the raster scanning mode with a focused primary beam, 11,12) whereas in SIMS analysis, the microscope mode with a broad primary ion beam is used. [13][14][15] During raster scanning, surface contamination may migrate into the analysis area when no beam is present, 16) whereas irradiation with a broad primary beam can avoid surface contamination. In this study, both a raster scanned primary beam and a broad beam were used for the depth profiling and evaluation of the oxygen ion background during the analysis.…”

Rapid screening of boron isotope ratios in nuclear shielding materials by LA-ICPMS – a comparison of two different instrumental setups

“…Traditionally, wet chemical mineralization methods are employed to digest steel samples for the determination of the trace element content and the isotopic composition. 3 Different mass spectrometric techniques like secondary ion mass spectrometry (SIMS), 4 isotope dilution thermal ionization mass spectrometry (ID-TIMS), [5][6][7] spark source mass spectrometry (SS-MS), 8 glow discharge mass spectrometry (GD-MS), 9 quadrupole inductively coupled plasma mass spectrometry (Q-ICPMS), [9][10][11][12] single collector sector eld inductively coupled plasma mass spectrometry (SF-ICPMS), 13 or multi-collector inductively coupled plasma mass spectrometry (MC-ICPMS) 7, [14][15][16] have been used for the determination of boron isotope ratios, mainly in geological samples and reference materials. Unconventional approaches like electrospray mass spectrometry (ES-MS) 17 or high resolution continuum source ame atomic absorption spectrometry (HR-CS-FAAS) 3 have been used for assessing boron isotope ratios as well.…”