Analytical method for the identification and assay of 12 phthalates in cosmetic products: Application of the ISO 12787 international standard “Cosmetics–Analytical methods–Validation criteria for analytical results using chromatographic techniques”

Gimeno, Pascal; Maggio, A.‐F.; Bousquet, Claudine; Quoirez, Audrey; Civade, Corinne; Bonnet, Pierre-Antoine

doi:10.1016/j.chroma.2012.06.090

Cited by 48 publications

(36 citation statements)

References 22 publications

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“…Phthalate esters (PAEs) are a group of chemical compounds that are wildly used as plasticisers and solvents in commercial, medical and personal care products [1,2]. Several million tons of phthalates are produced globally each year [3].…”

Section: Introductionmentioning

confidence: 99%

Monitoring of phthalates in foodstuffs using gas purge microsyringe extraction coupled with GC–MS

Yang

Ren-jie

et al. 2015

Analytica Chimica Acta

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Section: Introductionmentioning

confidence: 99%

Monitoring of phthalates in foodstuffs using gas purge microsyringe extraction coupled with GC–MS

Yang

Ren-jie

et al. 2015

Analytica Chimica Acta

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“…It was determined in environmental samples of wastewater by gas chromatography-mass spectrometry (GC-MS) [2] and liquid chromatography-tandem mass spectrometry (LC-MS/MS) [23], river water and tap water by GC-MS [1], soil by microemulsion electrokinetic chromatography [5], particulated materials from air by GC-MS [3], and house indoor dust by GC-MS/MS [4]. It was also determined in various commercial products, e.g., plasticized toys and child care items by GC-MS [24], aerosols by ultra high-performance liquid chromatography/photodiode array detection (UHPLC/PDA) [25], cosmetics by GC/flame ionization detection (GC/FID) [26] and GC-MS [27], beverages by HPLC/ultraviolet detection (HPLC/UVD) [28] and GC-MS/MS [29], bottled water by GC/FID [30] and GC-MS [1,31], edible oils by HPLC/diode array detection (HPLC/DAD) [32], wines by GC-MS [33], parenteral nutrition samples by LC-MS [34], and foodstuffs by GC-MS [34,35]. BBP was quantified in the biological samples of human urine and breast milk by LC-MS/MS [36,37].…”

Section: Introductionmentioning

confidence: 99%

Sensitive liquid chromatography-tandem mass spectrometry method for the simultaneous determination of benzyl butyl phthalate and its metabolites, monobenzyl phthalate and monobutyl phthalate, in rat plasma, urine, and various tissues collected from a toxicokinetic study

Kim

Shin

et al. 2015

Anal Bioanal Chem

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This study describes the development of a sensitive liquid chromatography-electrospray-tandem mass spectrometry method for the simultaneous determination of benzyl butyl phthalate (BBP) and its major metabolites, monobenzyl phthalate (MBzP) and monobutyl phthalate (MBuP), in rat plasma, urine, and 10 different tissues. The method was validated with regard to the specificity, linearity, precision, accuracy, lower limit of quantification (LLOQ), recovery, and stability by using the matrix-matched quality control samples. The assay achieved LLOQ of 1 ng/ml of BBP for plasma and urine, 4 ng/g for kidney and liver, 10 ng/g for fat, and 20 ng/g for all other tissues. For MBzP and MBuP, the assay achieved LLOQ of 5 ng/ml for plasma and urine, 10 ng/g for fat, and 20 ng/g for all other tissues. The disposition of BBP was characterized by a large volume of distribution (71.1-82.9 l/kg) and a high clearance (838.7-871.0 ml/min/kg). It was extensively metabolized to MBzP and MBuP, with their levels consistently exceeding the BBP levels. The distribution of BBP, MBzP, and MBuP to tissues of kidney, liver, stomach, small intestine, large intestine, spleen, brain, testis, thyroid, and fat was determined under steady-state conditions. For BBP, the steady-state tissue-to-plasma partition coefficient (K p) was the highest for fat (25.0) followed by small intestine (2.6), thyroid (2.0), and stomach (1.1). In contrast, for MBzP and MBuP, it was the highest for kidney (2.0 and 4.3, respectively) and liver (4.3 and 2.1, respectively) but was less than unity for all other tissues. The developed assay method and findings of this study may be useful to evaluate the exposure and toxic potential of BBP and its metabolites in risk assessment.

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“…The determination of PEs has mainly been carried out by GC-MS [11][12][13][14][15][16]. Taking into account the complexity of cleaning product matrices, a clean-up step has to be introduced in the whole analytical procedure.…”

Section: Introductionmentioning

confidence: 99%

Direct sample introduction gas chromatography and mass spectrometry for the determination of phthalate esters in cleaning products

Cacho

Campillo

Viñas

et al. 2015

Journal of Chromatography A

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Analytical method for the identification and assay of 12 phthalates in cosmetic products: Application of the ISO 12787 international standard “Cosmetics–Analytical methods–Validation criteria for analytical results using chromatographic techniques”

Cited by 48 publications

References 22 publications

Monitoring of phthalates in foodstuffs using gas purge microsyringe extraction coupled with GC–MS

Monitoring of phthalates in foodstuffs using gas purge microsyringe extraction coupled with GC–MS

Sensitive liquid chromatography-tandem mass spectrometry method for the simultaneous determination of benzyl butyl phthalate and its metabolites, monobenzyl phthalate and monobutyl phthalate, in rat plasma, urine, and various tissues collected from a toxicokinetic study

Direct sample introduction gas chromatography and mass spectrometry for the determination of phthalate esters in cleaning products

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