Analytical evaluation of HgbA1c, microalbumin, CRP, and RF on Architect ci8200 integrated system and workflow performance evaluation using computer simulation

Elefano, Elizabeth C.; Jabeen, Rukhsana; Onifade, Kehinde; Okorodudu, Anthony O.; Petersen, John R.; Mohammad, Amin A.

doi:10.1016/j.cca.2005.10.005

Cited by 2 publications

(3 citation statements)

References 19 publications

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“…38 Although this test obtains rapid results, the accuracy compared with values obtained by the standard assessment of HbA1c is questionable. 39 In contrast, our finger-stick and Whatman paper collection method and the standard immunoturbidimetric assessment of HbA1c on an Abbott ci8200 clinical chemistry analyzer 26 showed a very high correlation with the venipuncture collection method and subsequent HbA1c measurement (r=0.99). Despite a less accurate HbA1c determination, the results of the recent study 38 corroborate our findings that a substantial number of patients with suspected new diabetes in the periodontitis group can be found.…”

Section: Discussionmentioning

confidence: 84%

“…Two 6 mm punches were incubated in 400 μL hemolysis buffer of the standard HbA1c test, which was measured immunoturbidimetrically on an Abbott ci8200 clinical chemistry analyzer (Abbott Laboratories, Abbott Park, Illinois, USA). 26 The finger-stick and Whatman paper collection method was previously validated against the conventional EDTA blood collection by venipuncture according to the Clinical and Laboratory Standards Institute (CLSI) EP9 method comparison protocol. Precision and stability studies of HbA1c on Whatman 903 collection cards have been reported 27 and showed that the finger-stick collection card and punch method for HbA1c determination was highly correlated with the standard EDTA blood collection method (regression analysis r=0.99; see online supplementary figure S1).…”

Section: Blood Collection and Hba1c Analysismentioning

confidence: 99%

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Periodontitis as a possible early sign of diabetes mellitus

Teeuw

Kosho

Poland

et al. 2017

BMJ Open Diab Res Care

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ObjectiveThe early diagnosis of (pre)diabetes mellitus is essential for the prevention of diabetes complications. It has been suggested that gum disease (periodontitis) might be an early complication of diabetes and may be a useful risk indicator for diabetes screening. Therefore, a dental office could be a good location for screening for (pre)diabetes in patients with periodontitis using a validated glycated hemoglobin (HbA1c) dry spot analysis.Research design and methodsA total of 313 individuals from a university dental clinic participated. From 126 patients with mild/moderate periodontitis, 78 patients with severe periodontitis and 109 subjects without periodontitis, HbA1c values were obtained by the analysis of dry blood spots. Differences in mean HbA1c values and the prevalence of (pre)diabetes between the groups were analyzed.ResultsThe mild/moderate and severe periodontitis groups showed significantly higher HbA1c values (6.1%±1.4% (43 mmol/mol±15 mmol/mol) and 6.3%±1.3% (45 mmol/mol±15 mmol/mol), respectively) compared with the control group (5.7%±0.7% (39 mmol/mol±8 mmol/mol), p=0.003). In addition, according to the American Diabetes Association (ADA) guidelines for diagnosis, there was a significant over-representation of subjects with suspected diabetes (23% and 14%) and pre-diabetes (47% and 46%) in the severe periodontitis group and mild/moderate periodontitis groups, respectively, compared with the control group (10% and 37%, p=0.010). Notably, 18.1% of patients with suspected new diabetes were found among subjects with severe periodontitis compared with 9.9% and 8.5% among subjects with mild/moderate periodontitis and controls, respectively (p=0.024).ConclusionsThe dental office, with particular focus on patients with severe periodontitis, proved to be a suitable location for screening for (pre)diabetes; a considerable number of suspected new diabetes cases were identified. The early diagnosis and treatment of (pre)diabetes help to prevent more severe complications and benefit the treatment of periodontitis.

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Section: Discussionmentioning

confidence: 84%

Section: Blood Collection and Hba1c Analysismentioning

confidence: 99%

Periodontitis as a possible early sign of diabetes mellitus

Teeuw

Kosho

Poland

et al. 2017

BMJ Open Diab Res Care

View full text Add to dashboard Cite

show abstract

“…For setting the criteria for acceptable imprecision and inaccuracy, we considered the biological variations of analytes (7,10,11). Depending on the measurement procedure, measuring instruments and compliance with a reference or de nitive method, we can assess whether the new method or analyzer is suitable for routine use, and whether they are of satisfactory accuracy (2,3,5,12). For most analytes tested in this study, the results of imprecision and bias were in the range of desirable speci cations for imprecision and bias, derived from biological variation (10,11).…”

Section: Discussionmentioning

confidence: 99%

Analytical evaluation of the clinical chemistry analyzer Olympus AU2700 plus

et al. 2010

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Background: The objective of this study was to perform the analytical evaluation of the clinical chemistry analyzer Olympus AU2700 plus. The evaluation was performed according to the guidelines of the European Committee for Clinical Laboratory Standards (ECCLS). Materials and methods:The evaluation consisted of determination of within-run and between-run imprecision, inaccuracy and comparison with Olympus AU2700. The tested analytes were: glucose, creatinine, urate, total bilirubin, cholesterol, tryglicerides, calcium, phosphate, iron, unsaturated iron binding capacity, aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase, creatine kinase, alpha-amylase, alkaline phosphatase, potassium, sodium, chloride, C-reactive protein, antistreptolysin O and rheumatoid factor. Results: The results showed low within-run and between-run imprecision and acceptable inaccuracy for all analytes. High correlation with AU2700 analyzer was found. Intercept and slope (with 95% con dence interval) met the preferences of Passing-Bablok regression for all of the analytes except alanine aminotransferase, sodium, rheumatoid factor, creatine kinase, total bilirubin and tryglicerides. Conclusions: Olympus AU2700 plus analyzer shows acceptable precision and accuracy for majority of analytes, with the exception of sodium and chloride. Instrument is fully comparable with Olympus AU2700 analyzer for all but several analytes (ALT, RF, sodium, CK, total bilirubin and tryglicerides), where only some minor deviations (constant and proportional di erence) were observed.

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Analytical evaluation of HgbA1c, microalbumin, CRP, and RF on Architect ci8200 integrated system and workflow performance evaluation using computer simulation

Cited by 2 publications

References 19 publications

Periodontitis as a possible early sign of diabetes mellitus

Periodontitis as a possible early sign of diabetes mellitus

Analytical evaluation of the clinical chemistry analyzer Olympus AU2700 plus

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