Analytical Construct Resins for Analysis of Solid-Phase Chemistry

Application of a Dual Linker with a Reference Cleavage Site to Discover a New Reaction between Amines and N-Hydroxyphthalimide

“…The concept of dual linkers is not a new one and was recently reviewed. 2 We have already reported the use of a dual linker for the identification of a side-product in the Mitsunobu transformation of polymer-supported alcohols to amines. 3 Herein, we report the use of a dual linker with a reference cleavage site in the discovery of a new reaction between amines and N-hydroxyphthalimide (PhtNOH).…”

A synthesis of new, bi-labeled peptides for quantitative proteomics

“…We have, therefore, decided to develop an approach based on the concept of analytical construct [15,16]. This term was introduced by Geysen et al [17].…”

Monitoring Reactions on Solid Phases with Raman Spectroscopy

“…The most important methods, which offer several advantages such as non‐destructive analysis, have been introduced with the development of gel‐phase NMR analysis, the use of the magic‐angle spinning technique and 19 F NMR monitoring of reactions through introduction of fluorine linkers . IR and Raman measurements, both of which offer the advantage of very fast measurements, have also been used for monitoring reactions on polymeric material . Whereas IR analysis has already found its way into standard procedures for monitoring solid‐phase reactions and, in selected examples, the progress of the reaction, Raman and surface‐enhanced Raman spectroscopy has been reported only in a few applications for the identification of small compounds on solid phases, probably due to the limited availability of Raman instruments .…”