Analytical applications of chemiluminescence-detection systems assisted by magnetic microparticles and nanoparticles

Iranifam, Mortaza

doi:10.1016/j.trac.2013.05.014

Cited by 99 publications

(57 citation statements)

References 103 publications

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“…Due to the superparamagnetic property, MNPs can be accumulated accurately in a desired site by exerting an external field, which is thereby very suitable for the target delivery of genes and drugs . Also, MNPs can be applied in heat‐triggered drug release or in hyperthermia therapy by being heated in high‐frequency magnetic field . Specially, MNPs do not exhibit any magnetization after removing the external magnetic field.…”

Section: Introductionmentioning

confidence: 99%

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Current investigations into magnetic nanoparticles for biomedical applications

Jiang

Aifantis

et al. 2016

J Biomedical Materials Res

272

166

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It is generally recognized that nanoparticles possess unique physicochemical properties that are largely different from those of conventional materials, specifically the electromagnetic properties of magnetic nanoparticles (MNPs). These properties have attracted many researchers to launch investigations into their potential biomedical applications, which have been reviewed in this article. First, common types of MNPs were briefly introduced. Then, the biomedical applications of MNPs were reviewed in seven parts: magnetic resonance imaging (MRI), cancer therapy, the delivery of drugs and genes, bone and dental repair, tissue engineering, biosensors, and in other aspects, which indicated that MNPs possess great potentials for many kinds of biomedical applications due to their unique properties. Although lots of achievements have been obtained, there is still a lot of work to do. New synthesis techniques and methods are still needed to develop the MNPs with satisfactory biocompatibility. More effective methods need to be exploited to prepare MNPs-based composites with fine microstructures and high biomedical performances. Other promising research points include the development of more appropriate techniques of experiments both in vitro and in vivo to detect and analyze the biocompatibility and cytotoxicity of MNPs and understand the possible influencing mechanism of the two properties. More comprehensive investigations into the diagnostic and therapeutic applications of composites containing MNPs with "core-shell" structure and deeper understanding and further study into the properties of MNPs to reveal their new biomedical applications, are also described in the conclusion and perspectives part.

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Section: Introductionmentioning

confidence: 99%

“…[16][17][18] Also, MNPs can be applied in heat-triggered drug release or in hyperthermia therapy by being heated in high-frequency magnetic field. 19 Specially, MNPs do not exhibit any magnetization after removing the external magnetic field. Thus, their aggregation in vivo can be avoided.…”

Section: Introductionmentioning

confidence: 99%

Current investigations into magnetic nanoparticles for biomedical applications

Jiang

Aifantis

et al. 2016

J Biomedical Materials Res

272

166

View full text Add to dashboard Cite

show abstract

“…However, some biomarkers in the blood, including DNA, RNA, and many proteins, are generally present at very low concentrations [2, 3] and are difficult to detect due to severe interference from highly abundant proteins such as hemoglobin [4, 5]. Consequently, depletion of such abundant proteins is an essential prerequisite.…”

Section: Introductionmentioning

confidence: 99%

Selective Removal of Hemoglobin from Blood Using Hierarchical Copper Shells Anchored to Magnetic Nanoparticles

Liu

Wang

Yan

et al. 2017

BioMed Research International

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Hierarchical copper shells anchored on magnetic nanoparticles were designed and fabricated to selectively deplete hemoglobin from human blood by immobilized metal affinity chromatography. Briefly, CoFe2O4 nanoparticles coated with polyacrylic acid were first synthesized by a one-pot solvothermal method. Hierarchical copper shells were then deposited by immobilizing Cu2+ on nanoparticles and subsequently by reducing between the solid CoFe2O4@COOH and copper solution with NaBH4. The resulting nanoparticles were characterized by scanning electron microscopy, transmission electron microscopy, Fourier transform infrared spectrometry, X-ray photoelectron spectroscopy, and vibrating sample magnetometry. The particles were also tested against purified bovine hemoglobin over a range of pH, contact time, and initial protein concentration. Hemoglobin adsorption followed pseudo-second-order kinetics and reached equilibrium in 90 min. Isothermal data also fit the Langmuir model well, with calculated maximum adsorption capacity 666 mg g−1. Due to the high density of Cu2+ on the shell, the nanoparticles efficiently and selectively deplete hemoglobin from human blood. Taken together, the results demonstrate that the particles with hierarchical copper shells effectively remove abundant, histidine-rich proteins, such as hemoglobin from human blood, and thereby minimize interference in diagnostic and other assays.

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“…The CL method combined with microarray technology is a novel and powerful approach. It allows the simultaneous and rapid monitoring of hundreds of samples and requires only a small amount of reagent . New CL microarray technology may be a promising tool for clinical diagnosis.…”

Section: Introductionmentioning

confidence: 99%

“…amount of reagent. [13][14][15] New CL microarray technology may be a promising tool for clinical diagnosis.…”

Section: Introductionmentioning

confidence: 99%

A rapid and high‐throughput method for the determination of serum uric acid based on microarray technology and nanomaterial

Bai

Feng

et al. 2016

Luminescence

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Serum uric acid (SUA) is a new therapeutic target for non-alcoholic fatty liver disease (NAFLD). In this study, we introduced a chemiluminescence (CL) method combined with microarray technology and a simple fabrication procedure to obtain a highly sensitive SUA probe based on a mesoporous metal oxide nanomaterial. The high-throughput method was based on the generation of H O from SUA by immobilized uricase and its measurement by a CL reaction catalyzed by mesoporous metal oxide nanomaterials. The CL probe was designed for SUA The linear range of the uric acid concentration was 0.6-9 μM and the detection limit was 0.1 μM. In comparison with the other SUA detection techniques, this method has the advantages of a low detection limit, high sensitivity and simplicity. A new sensitive high-throughput approach was obtained for the determination of SUA.

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Analytical applications of chemiluminescence-detection systems assisted by magnetic microparticles and nanoparticles

Cited by 99 publications

References 103 publications

Current investigations into magnetic nanoparticles for biomedical applications

Current investigations into magnetic nanoparticles for biomedical applications

Selective Removal of Hemoglobin from Blood Using Hierarchical Copper Shells Anchored to Magnetic Nanoparticles

A rapid and high‐throughput method for the determination of serum uric acid based on microarray technology and nanomaterial

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