Analytical applications of biacetyl bis(4-phenyl-3-thiosemicarbazone) and bipyridylglyoxal bis(4-phenyl-3-thiosemicarbazone)

Asuero, Agustín G.; Gonzalez-Balairon, M.

doi:10.1016/0026-265x(80)90239-8

Cited by 27 publications

(3 citation statements)

References 65 publications

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“…The two classical methods as well as the new expressions have been applied to the pK a evaluation of the methylglyoxal bis (4-phenyl-3thiosemicarbazone) (MGBPT). [18][19] Although this reagent has two close pK a corresponding to the equilibria of the type expressed in the following scheme 20 applying the Coleman or Polster methods 1,[21][22][23] it can be shown that in the range of about 10-12pH, the two species corresponding to the first ionization equilibrium are found from a practical point of view.…”

Section: Methodsmentioning

confidence: 99%

Optimization of intersecting straight lines methods for the evaluation of acidity constants of single equilibria from spectrophotometric data

Martín

Asuero

Herrador

et al. 2018

PPIJ

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The acid dissociation constant (Ka) is among the most frequently used physicochemical parameters, and its determination is of interest to many research fields. A number of graphical methods has been proposed for the spectrophotometric evaluation of acidity constants of single equilibrium HR=H+R (charges omitted for the sake of generality), in those cases in which the limit absorbance's of the pure species HR or R, A1 and A0, respectively, are unknowns. The raw values of absorbance's versus pH data are transformed in linear functions, which allow to evaluate the unknown parameter Ka and A0/or A1 by a graphical approach or by the application of the least squares method. Among the various methods proposed the double reciprocal, Agren-Sommer and Nash methods yield to a family of intersecting straight lines when experimental measurements of absorbance and pH are made at different wavelengths. The purpose of this paper is to critically examine these methods on the basis of the requirements of single linear regression.

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Section: Methodsmentioning

confidence: 99%

Optimization of intersecting straight lines methods for the evaluation of acidity constants of single equilibria from spectrophotometric data

Martín

Asuero

Herrador

et al. 2018

PPIJ

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“…Numerous works have reported thiosemicarbazone-based complexes with therapeutic applications [2][3][4][5][6][7][8][9][10][11]. The ligands biacetyl bis (N-phenylhydrazonecarbothioamide) and bipyridyl glyoxal-N-phenylhydrazonecarbothioamide have been reported by spectrophotometric determinations [12]. Recently good number of investigations have been carried out to examine anticancer activities of thiosemicarbazones with platinum(II) and palladium(II) complexes [13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Analysis of platinum-based anticancer injections cisplatin and carboplatin in body fluids blood serum and urine of carcinogenic patients by photometry, fluorometry, liquid chromatography using Schiff-base 2-oxo-propanoic acid- N- phenylhydrazonecarbothioamide as derivatizing reagent

Khokhar,

Jahangir,

Khuhawar

et al. 2023

Preprint

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Photometric, fluorometric and liquid chromatographic methods were proposed to analyze platinum(II) from cis-platin and carbo-platin injections after derivatization with reagent 2-oxo-propanoic acid N-phenylhydrazonecarbothioamide. The reagent reacted with metals Au(III), Ag(I), Mn(II), Pt(II), Mo(VI), V(V/IV) to develop their characteristic colors in the pH range 3–12 and were extracted in organic solvent trichloromethane. The photoluminescent behaviour of ligand and its metal complexes was investigated to correlate the emission pattern. Liquid chromatographic method was also proposed to analyze cis-platin and carbo-platin anti-cancer drugs based on the pre-column derivatizing platinum(II) with ligand. The complex of platinum was separated and eluted from HPLC column Microsorb C-18, (150 cm x 4.6 mm i.d, 5µm) comprising eluents - tetrabutyl ammonium bromide (1mM)-sodium acetate (1mM)-acetonitrile-water-methanol (02:02:06:22:68 v/v/v/v/v). Metals gold(III), silver(I), manganese(II), vanadium(IV/V), molybdenum(VI) were also separated completely. The linear calibration range 0.5–2.5 µg/mL was observed following Beer’s law with detection limit of 150.00 ng/mL platinum(II). The determination of cis-platin and carbo-platin injections by photometric, fluorometric and chromatographic methods showed RSD (n = 3) 1.14–3.12, 0.98–2.84, 0.92–2.72% respectively. The developed methods were employed to analyze cis-platin in samples of serum and urine of carcinogenic patients undergoing chemotherapy and platinum amounts were observed within 45.0—86.0, 49.0—91.0, 42.0—84.0 ng.mL− 1 and 82.0—398, 81.0—389, 74.0—391 ng.mL− 1 with relative standard deviation (n = 4) of 2.28—3.88, 2.40—3.82, 2.52—3.82% and 2.52—3.91, 2.44—3.94, 1.98—3.24% by liquid chromatographic, fluorometric and photometric techniques respectively.

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“…The high molar absorptivities of the extracted chelates make these ligands promising analytical reagents if suitable means can be found for gaining the necessary selectivity. Biacetyl bis(4-phenyl-3-thiosemicarbazone) reacts with most first row transition metals plus bismuth, mercury, and palladium, and procedures for determining most of these metals have been devised (23).…”

mentioning

confidence: 99%

Ultraviolet and light absorption spectrometry

Howell¹,

Hargis²

1982

Anal. Chem.

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Analytical applications of biacetyl bis(4-phenyl-3-thiosemicarbazone) and bipyridylglyoxal bis(4-phenyl-3-thiosemicarbazone)

Cited by 27 publications

References 65 publications

Optimization of intersecting straight lines methods for the evaluation of acidity constants of single equilibria from spectrophotometric data

Optimization of intersecting straight lines methods for the evaluation of acidity constants of single equilibria from spectrophotometric data

Analysis of platinum-based anticancer injections cisplatin and carboplatin in body fluids blood serum and urine of carcinogenic patients by photometry, fluorometry, liquid chromatography using Schiff-base 2-oxo-propanoic acid- N- phenylhydrazonecarbothioamide as derivatizing reagent

Ultraviolet and light absorption spectrometry

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