2002
DOI: 10.1117/1.1501562
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Analysis on performance and optimization of frequency-domain near-infrared instruments

Abstract: Frequency-domain near-infrared techniques have been widely used to detect the optical properties of biological tissues noninvasively. In this paper we propose an analytical model to evaluate the performance of frequency-domain instruments. Based on the diffusion equation and the transfer properties of optoelectronic components, we treat all parts, including the medium, as two-port networks and apply systematic methods to answer questions concerning frequency-domain instruments. Experiments show that this metho… Show more

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Cited by 20 publications
(17 citation statements)
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“…Furthermore, the modulation depth m p in Eqs. (17) and (19) is dramatically decreased as the modulation frequency increases, which further degrades the estimation forφ. Although recently developed noise models for heterodyne and homodyne measurements indicate that small m p reduces σ 2 AC in Eq.…”
Section: Further Discussion and Conclusionmentioning
confidence: 99%
See 2 more Smart Citations
“…Furthermore, the modulation depth m p in Eqs. (17) and (19) is dramatically decreased as the modulation frequency increases, which further degrades the estimation forφ. Although recently developed noise models for heterodyne and homodyne measurements indicate that small m p reduces σ 2 AC in Eq.…”
Section: Further Discussion and Conclusionmentioning
confidence: 99%
“…Substituting a AC and σ 2 DC of Eqs. (17) and (18) to Eq. (14) produces γ for the case of heterodyne measurements, which is…”
mentioning
confidence: 99%
See 1 more Smart Citation
“…Due to large attenuation of light propagating in the medium, about 100 dB, and the noise that interferes with the signal, an appropriate design of the system is quite important to have good performance in subsequent analysis [72]. The signal first passes a transimpedance amplifier (TIA), bandpass filters (BPF), a multiplexer (MUX), and a constant gain amplifier (AMP).…”
Section: Methodsmentioning
confidence: 99%
“…The noise is especially significant in diffusive medical imaging, such as DOT and FLI, because of low photon counts. [12][13][14][15][16][17] The performance of noise-contaminated systems can be evaluated quantitatively by considering figures of merit (FOMs) that are chosen to reflect an observer's ability to perform these medial-relevant tasks. 15,18 Task-based assessment of image quality evaluates and/or optimizes diffusive imaging systems by employing FOMs that assess observer performance.…”
Section: Introductionmentioning
confidence: 99%